Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease

Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

(2022) Jakob A. Østergaard et al.   CLINICAL SCIENCE

The cGAS–STING pathway drives type I IFN immunopathology in COVID-19

(2022) Jeremy Di Domizio et al.   NATURE

Immunogenic cell stress and death

(2022) Guido Kroemer et al.   NATURE IMMUNOLOGY

PGC-1α inhibits the NLRP3 inflammasome via preserving mitochondrial viability to protect kidney fibrosis

(2022) Bo Young Nam et al.   Cell Death & Disease

POS-345 STING ACTIVATION CAUSES PROTEINURIA IN MICE AND CONTRIBUTES TO GLOMERULAR DISEASE

(2022) A. MITROFANOVA et al.   Kidney International Reports

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

(2022) Xiu Mei Ma et al.   CELL BIOLOGY AND TOXICOLOGY

Loss of Sam50 in hepatocytes induces cardiolipin‐dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury

(2022) Li Chen et al.   HEPATOLOGY

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model

(2022) Yanmin Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

(2022) Leah K. Billingham et al.   NATURE IMMUNOLOGY

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction

(2022) Hui Wang et al.   Cell Death & Disease

SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway

(2022) Wen-Yuan Wu et al.   Redox Biology

Mitochondrial RNAs as Potential Biomarkers of Functional Impairment in Diabetic Kidney Disease

(2022) Stefania Di Mauro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease

(2022) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Activation of Stimulator of Interferon Genes (STING) Causes Proteinuria and Contributes to Glomerular Diseases

(2022) Alla Mitrofanova et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO)

(2022) Ian H. de Boer et al.   KIDNEY INTERNATIONAL

SGLT2 Inhibitors in Chronic Kidney Disease: From Mechanisms to Clinical Practice

(2022) Roko Skrabic et al.   Biomedicines

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

(2021) Marco Tigano et al.   NATURE

Characterization of ferroptosis in kidney tubular cell death under diabetic conditions

(2021) Seonghun Kim et al.   Cell Death & Disease

Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice

(2021) Ki Ryang Na et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease

(2021) Xue-qi Liu et al.   ACTA PHARMACOLOGICA SINICA

Sp1-mediated upregulation of Prdx6 expression prevents podocyte injury in diabetic nephropathy via mitigation of oxidative stress and ferroptosis

(2021) Qianjin Zhang et al.   LIFE SCIENCES

Molecular mechanisms and consequences of mitochondrial permeability transition

(2021) Massimo Bonora et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice

(2021) Ya-chun Han et al.   Cell Death & Disease

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

(2020) Jeonghan Kim et al.   SCIENCE

NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

(2020) Orestes Foresto-Neto et al.   Frontiers in Physiology

PINK1/Parkin mediated mitophagy ameliorates palmitic acid-induced apoptosis through reducing mitochondrial ROS production in podocytes

(2020) Xu-shun Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

(2020) Satoshi Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin ubiquitinates GATA4 and attenuates the GATA4/GAS1 signaling and detrimental effects on diabetic nephropathy

(2020) Kehong Chen et al.   FASEB JOURNAL

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

(2020) Takahiro Yamazaki et al.   NATURE IMMUNOLOGY

Astragalus mongholicus Bunge and Panax notoginseng (Burkill) F.H. Chen Formula for Renal Injury in Diabetic Nephropathy—In Vivo and In Vitro Evidence for Autophagy Regulation

(2020) Dan Wen et al.   Frontiers in Pharmacology

Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation

(2020) Kai Wang et al.   Frontiers in Cell and Developmental Biology

APOL1 Kidney-Risk Variants Induce Mitochondrial Fission

(2020) Lijun Ma et al.   Kidney International Reports

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

(2020) Qian Cheng et al.   ACTA PHARMACOLOGICA SINICA

Mitophagy-Mediated mtDNA Release Aggravates Stretching-Induced Inflammation and Lung Epithelial Cell Injury via the TLR9/MyD88/NF-κB Pathway

(2020) Ren Jing et al.   Frontiers in Cell and Developmental Biology

Lipid deposition and metaflammation in diabetic kidney disease

(2020) Alla Mitrofanova et al.   CURRENT OPINION IN PHARMACOLOGY

Ferroptosis involves in renal tubular cell death in diabetic nephropathy

(2020) Yue Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy

(2019) Jia Sun et al.   JOURNAL OF ENDOCRINOLOGY

Cardiolipin-dependent mitophagy guides outcome after traumatic brain injury

(2019) Honglu Chao et al.   JOURNAL OF NEUROSCIENCE

Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy

(2019) Eun-Jung Lee et al.   Nutrients

Urinary mitochondrial DNA: A potential early biomarker of diabetic nephropathy

(2019) Hongdi Cao et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Double-Stranded RNA Sensors and Modulators in Innate Immunity

(2019) Sun Hur   Annual Review of Immunology

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

(2019) Paul T. Brinkkoetter et al.   Cell Reports

Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

(2019) Jung Hwan Bae et al.   Cells

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

(2019) Di Zhou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen

(2019) Rany M. Salem et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

(2019) Sih Min Tan et al.   DIABETES

A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications

(2019) Zi-Wei Yu et al.   LIFE SCIENCES

Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney

(2019) Safia Akhtar et al.   PLoS One

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

(2018) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

High Glucose-Induced Podocyte Injury Involves Activation of Mammalian Target of Rapamycin (mTOR)-Induced Endoplasmic Reticulum (ER) Stress

(2018) Jie Lei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy

(2018) Jianxun Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cytosolic sensing of immuno-stimulatory DNA, the enemy within

(2018) Rekha Dhanwani et al.   CURRENT OPINION IN IMMUNOLOGY

Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease

(2018) Eoin P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanism of parkin activation by PINK1

(2018) Christina Gladkova et al.   NATURE

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Optineurin-mediated mitophagy protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy

(2018) Kehong Chen et al.   Cell Death & Disease

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

The hallmarks of mitochondrial dysfunction in chronic kidney disease

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency

(2017) Evangelos Giampazolias et al.   NATURE CELL BIOLOGY

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis

(2017) Shuqin Mei et al.   Scientific Reports

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network

(2017) Xinhui Liu et al.   PLoS One

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

(2016) Haiying Qi et al.   DIABETES

Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak

(2016) Juan Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy

(2016) Anna Czajka et al.   Redox Biology

Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis

(2016) Wenduona Bao et al.   Scientific Reports

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress

(2015) Luis Alberto Luévano-Martínez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Chicken STING Mediates Activation of the IFN Gene Independently of the RIG-I Gene

(2015) Yuqiang Cheng et al.   JOURNAL OF IMMUNOLOGY

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury

(2015) Miaomiao Wei et al.   MOLECULAR IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

NF-κB in inflammation and renal diseases

(2015) Haisong Zhang et al.   Cell and Bioscience

Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

(2015) Xinxing Lu et al.   PLoS One

The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy

(2014) Hao Wu et al.   Autophagy

IκΒα inhibits apoptosis at the outer mitochondrial membrane independently of NF‐κB retention

(2014) Evangelos Pazarentzos et al.   EMBO JOURNAL

Mitochondrial DNA induces inflammation and increases TLR9/NF-κB expression in lung tissue

(2014) JIAN-ZHENG ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Characterization of cardiolipins and their oxidation products by LC–MS analysis

(2013) Yulia Y. Tyurina et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule–specific knockout mouse models

(2013) Qingqing Wei et al.   KIDNEY INTERNATIONAL

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

(2013) Felix Knauf et al.   KIDNEY INTERNATIONAL

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Identification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels

(2013) C. Arnarez et al.   Scientific Reports

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Toll-like receptor 9 and vascular endothelial growth factor levels in human kidneys from lupus nephritis patients

(2012) Marianne Frieri et al.   JOURNAL OF NEPHROLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Endothelial Cell and Platelet Bioenergetics: Effect of Glucose and Nutrient Composition

(2012) Brian D. Fink et al.   PLoS One

p53-Dependent Regulation of Mitochondrial Energy Production by the RelA Subunit of NF- B

(2011) R. F. Johnson et al.   CANCER RESEARCH

Transcriptome Analysis of Human Diabetic Kidney Disease

(2011) K. I. Woroniecka et al.   DIABETES

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

(2011) M. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease

(2011) S. Batsford et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure

(2010) ZiMian Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Bioenergetic characterization of mouse podocytes

(2010) Yoshifusa Abe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

(2010) H. Machida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Intracellular Shuttling and Mitochondrial Function of Thioredoxin-interacting Protein

(2009) Geetu Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response

(2009) ED Papadimitraki et al.   LUPUS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Serum lipids regulate dendritic cell CD1 expression and function

(2008) David S. Leslie et al.   IMMUNOLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Nuclear receptors and other nuclear transcription factors in mitochondria: Regulatory molecules in a new environment

(2007) Anna-Maria G. Psarra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH