Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

(2017) Michael C. Chang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress

(2017) Qinyue Guo et al.   Lipids in Health and Disease

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/β-Catenin Signaling Pathway

(2016) Rong Tian et al.   INFLAMMATION

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

(2016) Christine Altmann et al.   NEUROBIOLOGY OF DISEASE

Serum and Urinary Progranulin in Diabetic Kidney Disease

(2016) Bruna Bellincanta Nicoletto et al.   PLoS One

Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes

(2015) Lin Xu et al.   DISEASE MARKERS

Progranulin protects against renal ischemia/reperfusion injury in mice

(2015) Meng Zhou et al.   KIDNEY INTERNATIONAL

PGRN Induces Impaired Insulin Sensitivity and Defective Autophagy in Hepatic Insulin Resistance

(2015) Jiali Liu et al.   MOLECULAR ENDOCRINOLOGY

A new Classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy

(2015) Masakazu Haneda et al.   Journal of Diabetes Investigation

Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome

(2014) Huixia Li et al.   ENDOCRINOLOGY

Autophagy in diabetic nephropathy

(2014) Yan Ding et al.   JOURNAL OF ENDOCRINOLOGY

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy

(2014) Xiaojie Wang et al.   KIDNEY INTERNATIONAL

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Vps34 Deficiency Reveals the Importance of Endocytosis for Podocyte Homeostasis

(2013) W. Bechtel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

Autophagy Attenuates Diabetic Glomerular Damage through Protection of Hyperglycemia-Induced Podocyte Injury

(2013) Li Fang et al.   PLoS One

Autophagy: Emerging Therapeutic Target for Diabetic Nephropathy

(2013) Shinji Kume et al.   SEMINARS IN NEPHROLOGY

Serum Levels of the Adipokine Progranulin Depend on Renal Function

(2012) J. Richter et al.   DIABETES CARE

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

Nutrient Sensing, Autophagy, and Diabetic Nephropathy

(2011) S. Kume et al.   DIABETES

Dietary Restriction Ameliorates Diabetic Nephropathy through Anti-Inflammatory Effects and Regulation of the Autophagy via Restoration of Sirt1 in Diabetic Wistar Fatty (fa/fa) Rats: A Model of Type 2 Diabetes

(2011) Munehiro Kitada et al.   Experimental Diabetes Research

Autophagy as a Therapeutic Target in Diabetic Nephropathy

(2011) Yuki Tanaka et al.   Experimental Diabetes Research

Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism

(2011) Gabriel Frampton et al.   GUT

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK

(2010) Da-Fa Ding et al.   AMERICAN JOURNAL OF NEPHROLOGY

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth

(2010) Zhijun Luo et al.   Future Oncology

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

(2009) W. Lieberthal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY