Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Metabolic and Molecular Imaging of the Diabetic Cardiomyopathy

(2020) Linda R. Peterson et al.   CIRCULATION RESEARCH

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway

(2020) Chunyong Ding et al.   Acta Pharmaceutica Sinica B

The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy

(2020) Humna Bhagani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice

(2020) Juli Bai et al.   Communications Biology

STING cyclic dinucleotide sensing originated in bacteria

(2020) Benjamin R. Morehouse et al.   NATURE

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection

(2019) Qiang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STING-IRF3 contributes to lipopolysaccharide-induced cardiac dysfunction, inflammation, apoptosis and pyroptosis by activating NLRP3

(2019) Ning Li et al.   Redox Biology

Mitocellular communication: Shaping health and disease

(2019) Adrienne Mottis et al.   SCIENCE

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

TAX1BP1 overexpression attenuates cardiac dysfunction and remodeling in STZ-induced diabetic cardiomyopathy in mice by regulating autophagy

(2018) Yang Xiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Overexpression of CTRP3 protects against sepsis-induced myocardial dysfunction in mice

(2018) Wen-Ying Wei et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Obesity-induced activation of JunD promotes myocardial lipid accumulation and metabolic cardiomyopathy

(2018) Sarah Costantino et al.   EUROPEAN HEART JOURNAL

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells

(2017) Shiwei Liu et al.   PLoS One

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Emerging Roles of STING in Bacterial Infections

(2017) Fabio V. Marinho et al.   TRENDS IN MICROBIOLOGY

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

Lipid Use and Misuse by the Heart

(2016) P. Christian Schulze et al.   CIRCULATION RESEARCH

Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy

(2016) Rui Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial DNA sensing by STING signaling participates in inflammation, cancer and beyond

(2016) Song Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Receptor Interacting Protein Kinases Attenuates Cardiomyocyte Hypertrophy Induced by Palmitic Acid

(2016) Mingyue Zhao et al.   Oxidative Medicine and Cellular Longevity

The Mitochondria in Diabetic Heart Failure: From Pathogenesis to Therapeutic Promise

(2015) Joel D. Schilling   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Dynamics in Diabetic Cardiomyopathy

(2015) Chad A. Galloway et al.   ANTIOXIDANTS & REDOX SIGNALING

Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy

(2015) Francisco Westermeier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes

(2015) Petar M. Seferović et al.   EUROPEAN HEART JOURNAL

Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction

(2015) Dharendra Thapa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

(2014) David Montaigne et al.   CIRCULATION

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

Cytosolic-DNA-Mediated, STING-Dependent Proinflammatory Gene Induction Necessitates Canonical NF- B Activation through TBK1

(2014) T. Abe et al.   JOURNAL OF VIROLOGY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Metabolic dysfunction in diabetic cardiomyopathy

(2013) Michael Isfort et al.   HEART FAILURE REVIEWS

Adenovirus Detection by the cGAS/STING/TBK1 DNA Sensing Cascade

(2013) E. Lam et al.   JOURNAL OF VIROLOGY

Mitochondrial dysfunction and the inflammatory response

(2013) María J. López-Armada et al.   MITOCHONDRION

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cardiovascular Biology: Escaped DNA inflames the heart

(2012) Klitos Konstantinidis et al.   NATURE

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus

(2008) Luuk J. Rijzewijk et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY