ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions

Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion through enhancing tight junctions

(2022) Noriyuki Kinoshita et al.   iScience

Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function

(2021) Akira C. Saito et al.   MOLECULAR BIOLOGY OF THE CELL

Angulin-1 seals tricellular contacts independently of tricellulin and claudins

(2021) Taichi Sugawara et al.   JOURNAL OF CELL BIOLOGY

Tight Junction ZO Proteins Maintain Tissue Fluidity, Ensuring Efficient Collective Cell Migration

(2021) Mark Skamrahl et al.   Advanced Science

Premature Termination Codon-Bearing mRNA Mediates Genetic Compensation Response

(2020) Zhipeng Ma et al.   Zebrafish

Interplay between Extracellular Matrix Stiffness and JAM-A Regulates Mechanical Load on ZO-1 and Tight Junction Assembly

(2020) Alexis J. Haas et al.   Cell Reports

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity

(2019) Tetsuhisa Otani et al.   JOURNAL OF CELL BIOLOGY

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

(2019) Oliver Beutel et al.   CELL

Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow

(2019) Cornelia Schwayer et al.   CELL

CLIJ: GPU-accelerated image processing for everyone

(2019) Robert Haase et al.   NATURE METHODS

Tensile Forces and Mechanotransduction at Cell–Cell Junctions

(2018) Guillaume Charras et al.   CURRENT BIOLOGY

Adherens junctions influence tight junction formation via changes in membrane lipid composition

(2018) Kenta Shigetomi et al.   JOURNAL OF CELL BIOLOGY

Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity

(2018) Elisa Vitiello et al.   Nature Communications

An apical MRCK-driven morphogenetic pathway controls epithelial polarity

(2017) Ceniz Zihni et al.   NATURE CELL BIOLOGY

Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy

(2017) Alexander X. Cartagena-Rivera et al.   Nature Communications

αvβ3 integrins negatively regulate cellular forces by phosphorylation of its distal NPXY site

(2016) Rachel Milloud et al.   BIOLOGY OF THE CELL

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

(2015) Hüseyin Tuncay et al.   Nature Communications

MarvelD3 couples tight junctions to the MEKK1–JNK pathway to regulate cell behavior and survival

(2014) Emily Steed et al.   JOURNAL OF CELL BIOLOGY

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ZO-1 and ZO-2 Are Required for Extra-Embryonic Endoderm Integrity, Primitive Ectoderm Survival and Normal Cavitation in Embryoid Bodies Derived from Mouse Embryonic Stem Cells

(2014) Dominic C. Y. Phua et al.   PLoS One

ZO-1 Knockout by TALEN-Mediated Gene Targeting in MDCK Cells: Involvement of ZO-1 in the Regulation of Cytoskeleton and Cell Shape

(2014) Shinsaku Tokuda et al.   PLoS One

RhoGTPases, actomyosin signaling and regulation of the Epithelial Apical Junctional Complex

(2014) Miguel Quiros et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation

(2013) Ceniz Zihni et al.   JOURNAL OF CELL BIOLOGY

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel technique for micro-patterning proteins and cells on polyacrylamide gels

(2012) Xin Tang et al.   Soft Matter

Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

(2011) Stephen J. Terry et al.   NATURE CELL BIOLOGY

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

(2010) Tsutomu Oka et al.   BIOCHEMICAL JOURNAL

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

(2010) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics and functions of tight junctions

(2010) Emily Steed et al.   TRENDS IN CELL BIOLOGY

The elastic modulus of Matrigel™ as determined by atomic force microscopy

(2009) Shauheen S. Soofi et al.   JOURNAL OF STRUCTURAL BIOLOGY

ZO-1 Stabilizes the Tight Junction Solute Barrier through Coupling to the Perijunctional Cytoskeleton

(2009) Christina M. Van Itallie et al.   MOLECULAR BIOLOGY OF THE CELL

Physical forces during collective cell migration

(2009) Xavier Trepat et al.   Nature Physics

Deficiency of Zonula Occludens-1 Causes Embryonic Lethal Phenotype Associated with Defected Yolk Sac Angiogenesis and Apoptosis of Embryonic Cells

(2008) Tatsuya Katsuno et al.   MOLECULAR BIOLOGY OF THE CELL