Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology

Elovl5 Expression in the Central Nervous System of the Adult Mouse

(2021) Ilaria Balbo et al.   Frontiers in Neuroanatomy

The Causal Role of Lipoxidative Damage in Mitochondrial Bioenergetic Dysfunction Linked to Alzheimer’s Disease Pathology

(2021) Mariona Jové et al.   Life-Basel

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

(2021) Irina A. Pikuleva et al.   Frontiers in Aging Neuroscience

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

(2021) Se-In Lee et al.   Stem Cell Reports

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Roles of polyunsaturated fatty acids, from mediators to membranes

(2020) Takeshi Harayama et al.   JOURNAL OF LIPID RESEARCH

Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau

(2020) Carlo Giorgio Barracchia et al.   MOLECULES

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease

(2019) Joseph O. Ojo et al.   Frontiers in Neuroscience

APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1

(2019) Masaya Tachibana et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholesterol Biosynthesis and Uptake in Developing Neurons

(2019) Thiago C. Genaro-Mattos et al.   ACS Chemical Neuroscience

Altered SPMs and age-associated decrease in brain DHA in APOE4 female mice

(2019) Anneloes Martinsen et al.   FASEB JOURNAL

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

(2018) Bruno Dubois et al.   LANCET NEUROLOGY

Targeting the Brain with a Neuroprotective Omega-3 Fatty Acid to Enhance Neurogenesis in Hypoxic Condition in Culture

(2018) Amanda Lo Van et al.   MOLECULAR NEUROBIOLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content

(2018) Lydie Boussicault et al.   BIOCHIMIE

Endogenous Conversion of Omega-6 into Omega-3 Fatty Acids Improves Neuropathology in an Animal Model of Alzheimer's Disease

(2018) Meryem Lebbadi et al.   JOURNAL OF ALZHEIMERS DISEASE

The Effects of Long-Term Omega-3 Fatty Acid Supplementation on Cognition and Alzheimer's Pathology in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2018) Carlijn R. Hooijmans et al.   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease: Brain Desmosterol Levels

(2018) Thomas Wisniewski et al.   JOURNAL OF ALZHEIMERS DISEASE

Biophysical Alterations in Lipid Rafts from Human Cerebral Cortex Associate with Increased BACE1/AβPP Interaction in Early Stages of Alzheimer's Disease

(2018) Mario Díaz et al.   JOURNAL OF ALZHEIMERS DISEASE

Individual omega-9 monounsaturated fatty acids and mortality—The Ludwigshafen Risk and Cardiovascular Health Study

(2017) Graciela E. Delgado et al.   Journal of Clinical Lipidology

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

(2017) Célia Fourrier et al.   Journal of Neuroinflammation

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology

(2017) Kaoru Yamada   Frontiers in Neuroscience

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

(2017) Virginia Martín et al.   JOURNAL OF ALZHEIMERS DISEASE

Profiling Brain and Plasma Lipids in Human APOE ε2, ε3, and ε4 Knock-in Mice Using Electrospray Ionization Mass Spectrometry

(2017) Matthew J. Sharman et al.   JOURNAL OF ALZHEIMERS DISEASE

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease

(2016) Jessay Gopuran Devassy et al.   Advances in Nutrition

Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ

(2015) Chathyan Pararasa et al.   AGING CELL

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

(2015) Marie-Anne Burlot et al.   HUMAN MOLECULAR GENETICS

Role of Apolipoprotein E in β-Amyloidogenesis

(2015) Yukiko Hori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases A 1-42 Clearance

(2014) Y. Shibuya et al.   JOURNAL OF NEUROSCIENCE

Ceramides and sphingomyelinases in senile plaques

(2014) Maï Panchal et al.   NEUROBIOLOGY OF DISEASE

Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?

(2014) Raphaël Chouinard-Watkins et al.   Nutrients

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

(2012) Adina N. Lazar et al.   ACTA NEUROPATHOLOGICA

Very long-chain fatty acids: elongation, physiology and related disorders

(2012) A. Kihara   JOURNAL OF BIOCHEMISTRY

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models

(2011) Yadong Huang   BIOCHEMICAL SOCIETY TRANSACTIONS

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease

(2011) Emilie Cerf et al.   FASEB JOURNAL

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease

(2011) Giuseppe Astarita et al.   PLoS One

The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2, ε3 and ε4 knock-in mice

(2010) A.M. Jenner et al.   NEUROSCIENCE

Classification and basic pathology of Alzheimer disease

(2009) Charles Duyckaerts et al.   ACTA NEUROPATHOLOGICA

Docosahexaenoic Acid Modifies the Clustering and Size of Lipid Rafts and the Lateral Organization and Surface Expression of MHC Class I of EL4 Cells

(2009) Saame Raza Shaikh et al.   JOURNAL OF NUTRITION

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION