Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?

Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk

(2018) Cécilia Samieri et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

n–3 Fatty acid erythrocyte membrane content, APOE ε4, and cognitive variation: an observational follow-up study in late adulthood

(2018) Lawrence J Whalley et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals

(2014) Mélanie Plourde et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

Postprandial enrichment of triacylglycerol-rich lipoproteins with omega-3 fatty acids: lack of an interaction with apolipoprotein E genotype?

(2014) Valérie Conway et al.   Lipids in Health and Disease

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Double function at the blood–brain barrier

(2014) Christer Betsholtz   NATURE

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Blood-Brain Barrier: A Dual Life of MFSD2A?

(2014) Zhen Zhao et al.   NEURON

Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice

(2014) Valérie Conway et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

APOE genotype modifies the association between plasma omega-3 fatty acids and plasma lipids in the Multi-Ethnic Study of Atherosclerosis (MESA)

(2013) Shuang Liang et al.   ATHEROSCLEROSIS

Long-term effect of high dose omega-3 fatty acid supplementation for secondary prevention of cardiovascular outcomes: A meta-analysis of randomized, double blind, placebo controlled trials

(2013) Manuela Casula et al.   ATHEROSCLEROSIS SUPPLEMENTS

Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele

(2013) R. Chouinard-Watkins et al.   BRITISH JOURNAL OF NUTRITION

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals

(2013) Tauseef A Khan et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Reduction in DHA transport to the brain of mice expressing humanAPOE4compared toAPOE2

(2013) Milène Vandal et al.   JOURNAL OF NEUROCHEMISTRY

Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer’s disease

(2013) Francesca Fanelli et al.   Molecular Neurodegeneration

Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline

(2013) Marie Hennebelle et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults

(2012) Andrew L Carvalho-Wells et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice

(2012) Min Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Fish consumption, omega-3 fatty acids and risk of heart failure: A meta-analysis

(2012) Luc Djoussé et al.   CLINICAL NUTRITION

Marine omega-3 fatty acids and coronary heart disease

(2012) Philip C. Calder et al.   CURRENT OPINION IN CARDIOLOGY

Turning point: Mark Lawrence

(2012) Alexandra Bell   NATURE

Inhibition of peroxisomal β-oxidation by thioridazine increases the amount of VLCFAs and Aβ generation in the rat brain

(2012) Ruling Shi et al.   NEUROSCIENCE LETTERS

Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work?

(2011) D. Kromhout et al.   EUROPEAN HEART JOURNAL

Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in anin VitroBlood-Brain Barrier Model

(2011) Kazuchika Nishitsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIgh dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: the rancho bernardo study

(2011) L. B. Lopez et al.   Journal of Nutrition Health & Aging

Omega-3 polyunsaturated fatty acid supplements and cognitive decline: Singapore longitudinal aging studies

(2011) Q. Gao et al.   Journal of Nutrition Health & Aging

Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial

(2010) Philip Scheltens et al.   Alzheimers & Dementia

Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline

(2010) Karin Yurko-Mauro et al.   Alzheimers & Dementia

Interactions between age and apoE genotype on fasting and postprandial triglycerides levels

(2010) Andrew L. Carvalho-Wells et al.   ATHEROSCLEROSIS

OMEGA, a Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction

(2010) Bernhard Rauch et al.   CIRCULATION

Docosahexaenoic Acid Supplementation and Cognitive Decline in Alzheimer Disease

(2010) Joseph F. Quinn et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Omega-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression

(2010) Cécilia Samieri et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice

(2010) Jessica A. Siegel et al.   NEUROBIOLOGY OF AGING

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2

(2010) R.C. Klein et al.   NEUROSCIENCE

n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction

(2010) Daan Kromhout et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dietary fatty acids and the aging brain

(2010) Greg M Cole et al.   NUTRITION REVIEWS

Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease

(2010) Giuseppe Astarita et al.   PLoS One

Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: Higher fish intake or aging-related change in n-3 fatty acid metabolism?

(2010) M. Fortier et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

(2009) Mark Bouwens et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

APOE Genotype, Lipids, and Coronary Heart Disease Risk

(2009) Heather Ward et al.   ARCHIVES OF INTERNAL MEDICINE

Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS)

(2009) Shinichi Oikawa et al.   ATHEROSCLEROSIS

Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil

(2009) Estibaliz Olano-Martin et al.   ATHEROSCLEROSIS

Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women

(2009) Marie-Noël Vercambre et al.   BRITISH JOURNAL OF NUTRITION

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE 4 but not by the common PPAR-α L162V polymorphism in men

(2009) Mélanie Plourde et al.   BRITISH JOURNAL OF NUTRITION

Regional atrophy of transcallosal prefrontal connections in cognitively normalAPOEϵ4 carriers

(2009) Nicola Filippini et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood–brain barrier: An in situ cerebral perfusion study

(2009) Melissa Ouellet et al.   NEUROCHEMISTRY INTERNATIONAL

Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer’s disease

(2008) Judes Poirier   Alzheimers & Dementia

Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks

(2008) Alexandra Bour et al.   BEHAVIOURAL BRAIN RESEARCH

Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study

(2008) Marjo H. Eskelinen et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease

(2008) Cynthia Boudrault et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial

(2008) GISSI-HF investigators   LANCET

Plasma Omega-3 Fatty Acid Response to a Fish Oil Supplement in the Healthy Elderly

(2008) Milène Vandal et al.   LIPIDS

Effect of fish oil on cognitive performance in older subjects: A randomized, controlled trial

(2008) O. van de Rest et al.   NEUROLOGY

Eicosapentaenoic acid decreases postprandial β-hydroxybutyrate and free fatty acid responses in healthy young and elderly

(2008) Mélanie Plourde et al.   NUTRITION

The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: A preliminary randomized double-blind placebo-controlled study

(2008) Chih-Chiang Chiu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY