Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

(2022) Teng Ma et al.   NATURE

The PCK2-glycolysis axis assists three-dimensional-stiffness maintaining stem cell osteogenesis

(2022) Zheng Li et al.   Bioactive Materials

Bone tissue and histological and molecular events during development of the long bones

(2021) Michael J.F. Blumer   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Phosphoenolpyruvate Carboxykinase in Cell Metabolism: Roles and Mechanisms Beyond Gluconeogenesis

(2021) Shuo Yu et al.   Molecular Metabolism

CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65

(2021) Yangge Du et al.   EMBO REPORTS

Stat3 loss in mesenchymal progenitors causes Job syndrome–like skeletal defects by reducing Wnt/β-catenin signaling

(2021) Prem Swaroop Yadav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease

(2021) Patrycja Puchalska et al.   Annual Review of Nutrition

STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis

(2021) Siru Zhou et al.   Nature Communications

The Osteocyte: New Insights

(2020) Alexander G. Robling et al.   Annual Review of Physiology

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

(2020) Guadalupe Del Carmen Baeza-Flores et al.   Frontiers in Pharmacology

Role of Metabolism in Bone Development and Homeostasis

(2020) Akiko Suzuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin-loaded nanospheres laden photocrosslinkable gelatin hydrogel for bone tissue engineering

(2020) Liu Qu et al.   Journal of the Mechanical Behavior of Biomedical Materials

Craniofacial and Long Bone Development in the Context of Distraction Osteogenesis

(2020) Harsh N. Shah et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

Early Treatment With Metformin in a Mice Model of Complex Regional Pain Syndrome Reduces Pain and Edema

(2019) Vaskar Das et al.   ANESTHESIA AND ANALGESIA

Gluconeogenesis in cancer cells – Repurposing of a starvation-induced metabolic pathway?

(2019) Gabriele Grasmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes

(2019) Jennifer McKenzie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids

(2019) Juliane Zemdegs et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) regulates osteogenic differentiation by modulating AMPK/ULK1-dependent autophagy

(2019) Zheng Li et al.   STEM CELLS

Lipids in the Bone Marrow: An Evolving Perspective

(2019) Elizabeth Rendina-Ruedy et al.   Cell Metabolism

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes

(2019) Lin Jiating et al.   Biomed Research International

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation

(2018) Markus Linder et al.   CELL DEATH AND DIFFERENTIATION

BCAA Metabolism and Insulin Sensitivity - Dysregulated by Metabolic Status?

(2018) Nicholas P. Gannon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Metabolism: Role of bone in glucose metabolism

(2018) Claire Greenhill   Nature Reviews Endocrinology

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

(2018) Xinjian Li et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

(2018) Niamh C. Williams et al.   Frontiers in Immunology

Synergistic effect of extracellularly supplemented osteopontin and osteocalcin on stem cell proliferation, osteogenic differentiation, and angiogenic properties

(2018) Marta S Carvalho et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Novel Calcium Phosphate Cement with Metformin-Loaded Chitosan for Odontogenic Differentiation of Human Dental Pulp Cells

(2018) Wei Qin et al.   Stem Cells International

Metformin Promotes Osteogenic Differentiation of Adipose-Derived Stromal Cells and Exerts Pro-Osteogenic Effect Stimulating Bone Regeneration

(2018) Agnieszka Śmieszek et al.   Journal of Clinical Medicine

Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells

(2017) Ping Wang et al.   Journal of Tissue Engineering and Regenerative Medicine

Expression of an active Gαsmutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance

(2017) Xuefeng Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone up: craniomandibular development and hard-tissue biomineralization in neonate mice

(2017) Khari D. Thompson et al.   ZOOLOGY

Intracranial and hierarchical perspective on dietary plasticity in mammals

(2017) Erin M. Franks et al.   ZOOLOGY

Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state

(2017) Philipp Schommers et al.   Molecular Metabolism

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

VEGF stimulates intramembranous bone formation during craniofacial skeletal development

(2016) Xuchen Duan et al.   MATRIX BIOLOGY

Metformin Prevents Fatty Liver and Improves Balance of White/Brown Adipose in an Obesity Mouse Model by Inducing FGF21

(2016) Eun Kyung Kim et al.   MEDIATORS OF INFLAMMATION

Inside out: Bone marrow adipose tissue as a source of circulating adiponectin

(2016) Erica L. Scheller et al.   Adipocyte

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

(2015) Emma E. Vincent et al.   MOLECULAR CELL

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction

(2014) Kacey J. Prentice et al.   Cell Metabolism

Metformin Lowers Plasma Triglycerides by Promoting VLDL-Triglyceride Clearance by Brown Adipose Tissue in Mice

(2013) J. J. Geerling et al.   DIABETES

PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis

(2013) Andrés Méndez-Lucas et al.   JOURNAL OF HEPATOLOGY

Impact of diabetes and its treatments on skeletal diseases

(2013) Wenbo Yan et al.   Frontiers of Medicine

Cellular and Molecular Mechanisms of Bone Remodeling

(2010) Liza J. Raggatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism