Review
Biochemistry & Molecular Biology
Lamberta Ghaly, Vincent Bargnes, Sadiq Rahman, George-Abraam Tawfik, Sergio Bergese, William Caldwell
Summary: Complex regional pain syndrome (CRPS) is a rare and debilitating chronic pain disorder characterized by persistent pain that is disproportionate to any preceding injury. It can significantly impact a person's quality of life, resulting in disability and psychological distress. Despite being recognized for over a century, finding effective treatment for CRPS remains challenging.
Review
Immunology
Takayuki Okumo, Yasunori Takayama, Kenta Maruyama, Mami Kato, Masataka Sunagawa
Summary: CRPS is a chronic pain syndrome associated with tissue injuries, where TRPA1 activation, bone atrophy, and abnormal bone turnover may play crucial roles. TRPA1 may be a key player in the pathophysiology of CRPS, affecting pain sensation and bone health.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Behavioral Sciences
Paula Franson Fernandes, Taynah de Oliveira Galassi, Veronica Vargas Horewicz, Afonso Shiguemi Inoue Salgado, Josiel Mileno Mack, Heloiza dos Santos Baldanca, Ana Paula Ferreira da Silva, Stephen Bruehl, Edsel B. Bittencourt, Lynsey A. Seim, Daniel Fernandes Martins, Franciane Bobinski
Summary: This study aimed to evaluate the clinical and immunoregulatory effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation on paw edema and anti- and pro-inflammatory cytokines in the chronic post-ischemia pain (CPIP) preclinical model of CRPS-Type I. The results suggest that omega-3 PUFA supplementation has anti-inflammatory effects, significantly reducing paw edema and regulating concentrations of anti-inflammatory cytokines.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Myeounghoon Cha, Kyung Hee Lee, Minjee Kwon, Bae Hwan Lee
Summary: The study compared the pain relief effects of different drugs in a rat model of chronic post-ischemic pain-induced CRPS, finding that these drugs effectively alleviated CRPS-induced mechanical allodynia, improved mechanical sensitivity, and reduced the expression of inflammatory factors.
Article
Anesthesiology
Xiaoyou Shi, Tian-zhi Guo, Wen-wu Li, Frank Birklein, Fabiola L. Escolano, Myriam Herrnberger, J. David Clark, Wade S. Kingery
Summary: The study found that early CRPS IgM antibodies have pronociceptive effects in fracture mice, potentially by activating C5a complement signaling pathway leading to increased proinflammatory cytokine expression in the skin and spinal cord, contributing to nociceptive sensitization in the injured limb.
Article
Pharmacology & Pharmacy
Shiho Shibata, Hideaki Tagashira, Takayuki Nemoto, Satomi Kita, Tomo Kita, Yasuharu Shinoda, Kouzaburo Akiyoshi, Ken Yamaura, Takahiro Iwamoto
Summary: Complex regional pain syndrome (CRPS) is a chronic pain syndrome characterized by various signs and symptoms. The study suggests that inflammatory cytokines like TNF-a and IL-1b may be potential therapeutic targets for CRPS. The researchers created a novel CRPS mouse model and found that administration of an anti-TNF-a antibody alleviated CRPS-related signs and suppressed inflammatory response in injured peripheral nerves.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Behavioral Sciences
Axel D. Vitterso, Gavin Buckingham, Antonia F. Ten Brink, Monika Halicka, Michael J. Proulx, Janet H. Bultitude
Summary: This study found no evidence of impaired strategic control or sensorimotor realignment in individuals with Complex Regional Pain Syndrome (CRPS). However, there was some indication that there could be a greater propensity for sensorimotor realignment in the CRPS-affected arm when using the affected hand.
Article
Anesthesiology
Krista Baerg, Susan M. Tupper, Luan Manh Chu, Nicole Cooke, Bruce D. Dick, Marie-Joelle Dore-Bergeron, Sheri Findlay, Pablo M. Ingelmo, Christine Lamontagne, Giulia Mesaroli, Tim F. Oberlander, Raju Poolacherla, Adam Oscar Spencer, Jennifer Stinson, G. Allen Finley
Summary: This study describes the minimum incidence, clinical features, and recommended treatments of pediatric complex regional pain syndrome (CRPS) in Canada. The study found that CRPS has a higher incidence in girls aged 12 and older, with most cases involving the lower limbs. Nonsteroidal anti-inflammatory drugs and acetaminophen were the most commonly prescribed treatments, and there is a need for increased promotion of pain education.
Article
Medicine, Research & Experimental
Richa Pande, Ayush Parikh, Botros Shenoda, Sujay Ramanathan, Guillermo M. Alexander, Robert J. Schwartzman, Seena K. Ajit
Summary: CRPS is a chronic pain condition characterized by inflammation and debilitating pain. Downregulation of miR-605 may exacerbate inflammation and affect the expression of CXCL5. Further studies suggest that miR-605 may regulate inflammation by modulating CXCL5 in patients with poor response to ketamine.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Behavioral Sciences
Janet H. Bultitude, Karin Petrini
Summary: The study found that individuals with CRPS can optimally integrate visual and self-motion cues under some conditions, despite their lower reliability, and use different strategies compared to controls.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Health Care Sciences & Services
Soo Jin Kwon, Yoonjung Kim
Summary: This study examined the experiences and challenges of 11 Korean patients diagnosed with complex regional pain syndrome, finding that they experienced unique pain and complex emotions, as well as feelings of loneliness and lack of support.
Article
Anesthesiology
Monika Halicka, Axel D. Vitterso, Hayley McCullough, Andreas Goebel, Leila Heelas, Michael J. Proulx, Janet H. Bultitude
Summary: The study found no evidence to support the efficacy of prism adaptation treatment for relieving upper-limb CRPS-I pain. There were no differences in primary or secondary outcomes between the prism adaptation and sham treatment groups at either time point after treatment.
Review
Neurosciences
Tian-Shu Li, Rui Wang, Xuan Su, Xue-Qiang Wang
Summary: Complex regional pain syndrome causes severe pain and dysfunction, greatly impacting patients' quality of life. Exercise therapy is gaining attention for its ability to relieve pain and improve physical function. This article summarizes the effectiveness and underlying mechanisms of exercise interventions for complex regional pain syndrome, and outlines a progressive multi-stage exercise program. Exercise options for patients with complex regional pain syndrome include graded motor imagery, mirror therapy, progressive stress loading training, and progressive aerobic training. Overall, exercise training for complex regional pain syndrome not only reduces pain, but also improves physical function and mental well-being. The underlying mechanisms of exercise interventions include remodeling the nervous system, regulating blood flow and stress levels, releasing endogenous opioids, and increasing anti-inflammatory cytokines. This article provides a clear explanation and summary of exercise research for complex regional pain syndrome. In the future, more high-quality studies with larger sample sizes may provide additional exercise regimens and stronger evidence of effectiveness.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Behavioral Sciences
Juliete Palandi, Josiel Mileno Mack, Isabela Longo de Araujo, Marcelo Farina, Franciane Bobinski
Summary: This study provides a comprehensive framework of animal models used to investigate CRPS by reviewing 93 preclinical studies. The results show that the main objective of the included studies was to understand the CRPS model, with the most common characteristics being rats, males, and adults exposed to ischemia/reperfusion or tibia fracture. The most widely adopted method for nociceptive evaluation was the use of von Frey monofilaments. However, future studies should include more heterogeneous animals, multiple assessment tools, and improve measures to reduce bias for better translational science between animal models and individuals with CRPS.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Review
Anesthesiology
Giulia Mesaroli, Amos Hundert, Kathryn A. Birnie, Fiona Campbell, Jennifer Stinson
Summary: CRPS is a severely painful condition with four identified diagnostic tools but none validated for pediatric populations. Future research is recommended to develop diagnostic tools for pediatric CRPS and screening tools for both pediatric and adult populations.
Article
Anesthesiology
Antje M. Barreveld, Robert J. McCarthy, Nabil Elkassabany, Edward R. Mariano, Brian Sites, Roshni Ghosh, Asokumar Buvanendran
Article
Radiology, Nuclear Medicine & Medical Imaging
Camila Lopes Vendrami, Xinchun Xu, Robert J. McCarthy, Joon Soo Shin, Lori A. Goodhartz, Jeanne M. Horowitz, Donald Kim, Frank H. Miller
ABDOMINAL RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Camila Lopes Vendrami, Robert J. McCarthy, Carolina Parada Villavicencio, Frank H. Miller
ABDOMINAL RADIOLOGY
(2020)
Editorial Material
Anesthesiology
A. J. Butwick, R. J. McCarthy
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA
(2021)
Article
Anesthesiology
Asokumar Buvanendran, Amanda C. Sremac, Patricia A. Merriman, Craig J. Della Valle, John W. Burns, Robert J. McCarthy
Summary: CBT interventions delivered prior to surgery, either in person or via telehealth, can reduce PCS scores, but this reduction does not lead to improved 3-month pain outcomes.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Letter
Anesthesiology
H. B. Ende, B. Tran, M. Thampy, J. R. Bauchat, R. J. McCarthy
INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA
(2021)
Article
Anesthesiology
Louanne M. Carabini, Ashley N. Budd, Patricia Bochey, Shahriar Shayan, Glenn Ramsey, Robert J. McCarthy
Summary: The study found that establishing institutional protocols for the use of 4F-PCC to reverse the effects of anticoagulation and to treat critical bleeding with associated coagulopathy was associated with reduced plasma utilization.
JOURNAL OF CLINICAL ANESTHESIA
(2021)
Article
Anesthesiology
Robert J. McCarthy, Ashley Meng Adams, Amanda C. Sremac, Wendy Jo Kreider, Pete L. Pelletier, Asokumar Buvanendran
Summary: This study identified distinct opioid use trajectories following abdominal, joint, or spine surgery, which were associated with different patterns of postoperative pain and duration of opioid use. Patients in the persistent opioid use trajectory had higher reported pain levels and longer duration of opioid use compared to those in the decreasing use trajectory. Identification of postoperative opioid use trajectory groups may be important for predicting risk of prolonged opioid use.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Article
Anesthesiology
Prachi M. Patel, Mary C. Leemputte, Robert J. McCarthy, Honorio Benzon
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Letter
Anesthesiology
Robert J. McCarthy, Asokumar Buvanendran
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2022)
Article
Anesthesiology
Hubert A. Benzon, Anthony Tantoco, Anthony Longhini, John Hajduk, Amanda Saratsis, Santhanam Suresh, Robert J. McCarthy, Narasimhan Jagannathan
Summary: This study aimed to examine the impact of anesthesia-related intraoperative complications on unanticipated admission to the intensive care unit after posterior fossa decompression for Chiari I Malformation. The results demonstrated that although anesthesia-related intraoperative complications are infrequent, they are associated with an increased risk of unanticipated admission to the intensive care unit.
PEDIATRIC ANESTHESIA
(2022)
Article
Medicine, General & Internal
Giovanni Berardi, Laura Frey-Law, Kathleen A. Sluka, Emine O. Bayman, Christopher S. Coffey, Dixie Ecklund, Carol G. T. Vance, Dana L. Dailey, John Burns, Asokumar Buvanendran, Robert J. McCarthy, Joshua Jacobs, Xiaohong Joe Zhou, Richard Wixson, Tessa Balach, Chad M. Brummett, Daniel Clauw, Douglas Colquhoun, Steven E. Harte, Richard E. Harris, David A. Williams, Andrew C. Chang, Jennifer Waljee, Kathleen M. Fisch, Kristen Jepsen, Louise C. Laurent, Michael Olivier, Carl D. Langefeld, Timothy D. Howard, Oliver Fiehn, Jon M. Jacobs, Panshak Dakup, Wei-Jun Qian, Adam C. Swensen, Anna Lokshin, Martin Lindquist, Brian S. Caffo, Ciprian Crainiceanu, Scott Zeger, Ari Kahn, Tor Wager, Margaret Taub, James Ford, Stephani P. Sutherland, Laura D. Wandner
Summary: Chronic pain is a global health problem that reduces quality of life, but its clinical management has been hindered by incomplete understanding of risk factors and molecular mechanisms. The A2CPS Program aims to predict chronic pain development following surgery using biomarkers. This study collects standardized data from multiple clinical sites to advance understanding of the transition from acute to chronic postsurgical pain.
FRONTIERS IN MEDICINE
(2022)
Article
Anesthesiology
Vaskar Das, Michael B. Basovich, Jeffrey S. Kroin, Asokumar Buvanendran, Robert J. McCarthy
Summary: The study demonstrates that the peripheral AMPKa activator O304 reduces allodynia in a dose-dependent manner and modulates protein expression in the dorsal root ganglion (DRG).
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Clinical Neurology
Giovanni Berardi, Laura Frey-Law, Carol G. T. Vance, Emine O. Bayman, Christopher S. Coffey, Dana L. Dailey, Dixie Ecklund, Kathleen A. Sluka, Tessa Balach, John Burns, Asokumar Buvanendran, Joshua Jacobs, Robert J. McCarthy, Richard Wixson, Xiaohong Joe Zhou, Chad M. Brummett, Andrew Chang, Daniel Clauw, Douglas Colquhoun, Richard E. Harris, Steven Harte, Jennifer Waljee, David A. Williams, Panshak Dakup, Oliver Fiehn, Kathleen M. Fisch, Timothy D. Howard, Jon M. Jacobs, Kristen Jepsen, Carl D. Langefeld, Louise C. Laurent, Anna Lokshin, Michael Olivier, Wei-Jun Qian, Adam C. Swensen, Brian Caffo, Ciprian Crainiceanu, James Ford, Ari Kahn, Martin Lindquist, Stephani P. Sutherland, Margaret Taub, Tor Wager, Nicolas Johnston, Laura D. Wandner
Meeting Abstract
Clinical Neurology
Kathleen Sluka, Laura Frey Law, Christopher Coffey, Emine Bayman, Dixie Ecklund, Carol Vance, Dana Dailey, Tor Wager, Martin Lindquist, Ari Kahn, John Burns, Robert McCarthy, Joshua Jacobs, Asokumar Buvanendran, Xiaohong Zhou, Chad Brummett, Daniel Clauw, David Williams