Article
Biochemistry & Molecular Biology
Meng Chen, Liying Shan, Ying Gan, Lijie Tian, Jie Zhou, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: MTSS1 plays a role in osteoblast differentiation and bone homeostasis by regulating Src-Wnt/beta-catenin signaling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Ye-Ya Tan, Yin Zhang, Bin Li, Yang-Wen Ou, Shu-Juan Xie, Pei-Pei Chen, Shi-Qiang Mei, Qiao-Juan Huang, Ling-Ling Zheng, Liang-Hu Qu
Summary: The PERK signaling plays a crucial role in the maintenance and differentiation of myoblasts by regulating miRNA networks. Knocking down PERK leads to the transformation of C2C12 myoblasts into stem-like cells and activation of muscle differentiation-associated miRNA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Guoyin Li, Zewen Song, Changjing Wu, XiaoYan Li, Liping Zhao, Binghua Tong, Zhenni Guo, Meiqing Sun, Jin Zhao, Huina Zhang, Lintao Jia, Shengqing Li, Lei Wang
Summary: Cumulative evidence suggests that abnormal regulation of the NEDD4 family is involved in tumorigenesis and cancer development. This study found that NEDD4L is associated with overall survival in lung adenocarcinoma (LUAD) patients and may regulate the mTORC1 pathway. Experimental results demonstrate that NEDD4L inhibits mTOR signaling activity and significantly inhibits LUAD cell proliferation. Additionally, the expression of NEDD4L is regulated by EGFR signaling.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Liangcong Hu, Xudong Xie, Hang Xue, Tiantian Wang, Adriana C. Panayi, Ze Lin, Yuan Xiong, Faqi Cao, Chengcheng Yan, Lang Chen, Peng Cheng, Kangkang Zha, Yun Sun, Guodong Liu, Chenyan Yu, Yiqiang Hu, Ranyang Tao, Wu Zhou, Bobin Mi, Guohui Liu
Summary: miR-1224-5p is a key regulator of bone osteogenesis, which is associated with fracture healing and osteoporosis development. By targeting ADCY2 and the Rap1 signaling pathway, miR-1224-5p can slow down osteoclast differentiation and promote osteoblast differentiation. In vivo experiments showed that overexpression of miR-1224-5p can promote fracture healing and ameliorate the progression of osteoporosis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Biomedical
John Akrofi Kubi, Augustine Suurinobah Brah, Kenneth Man Chee Cheung, Yin Lau Lee, Kai-Fai Lee, Stephen Cho Wing Sze, Wei Qiao, Kelvin Wai-Kwok Yeung
Summary: Delayed bone defect repair has significant negative impacts on patients' health and socioeconomic status. Recombinant proteins like BMP-2 are commonly used for bone defect repairs, but they can cause adverse side effects. In this study, we have discovered a new osteogenic protein called HKUOT-S2, which accelerates bone defect repair by activating MSCs-derived osteoblasts and enhancing osteoblastic biomineralization. The protein also modulates the transcriptomic changes of macrophages, stem cells, and osteoblasts, facilitating osteogenesis. The HKUOT-S2 protein shows no toxicity and has great potential as an alternative treatment for bone defect healing.
BIOACTIVE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Vishwa Deepak, Shu-Ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Summary: This study identifies a negative function of IFT80 in osteoclasts by regulating the stabilization and degradation of Cbl-b and TRAF6, thereby affecting osteoclast formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Toshihisa Komori
Summary: Runx2 is a crucial transcription factor in bone development, playing a key role in the maturation and proliferation of chondrocytes and osteoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Jung-Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin Chaugule, Hyonho Chun, Marjolein C. H. van Der Meulen, Ren Xu, Matthew B. Greenblatt, Jae-Hyuck Shim
Summary: Emerging evidence suggests that the ERK pathway in osteoblasts controls bone formation by suppressing the mTOR pathway, promoting mitochondrial function and SGK1 phosphorylation. While ERK inhibition blocks early differentiation of osteogenic precursors, it surprisingly promotes later stages of osteoblast differentiation, leading to enhanced bone formation. This study reveals a surprising dichotomy of ERK pathway functions in osteoblasts, where ERK activation promotes early differentiation but inhibits the subsequent differentiation via mTOR-mediated regulation of mitochondrial function and SGK1.
Article
Biochemistry & Molecular Biology
Kabsun Kim, Jung Ha Kim, Inyoung Kim, Semun Seong, Jeong Eun Han, Keun-Bae Lee, Jeong-Tae Koh, Nacksung Kim
Summary: Lmx1b negatively regulates osteoblast differentiation and function through repression of Runx2, providing a molecular basis for therapeutic targets in bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xiao-Jing Gu, Ya-Jun Li, Fang Wang, Ting Ye
Summary: The study identifies the involvement of miR-30e-3p/THOC2 axis in the development and progression of gastric cancer, suggesting its potential as a target for developing new therapies against gastric cancer.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Plant Sciences
Ming-Shi Ren, Hui-Hui Xie, Yu Ding, Zi-Han Li, Bo Liu
Summary: This study aimed to determine whether the serum containing EXD promotes the proliferation and differentiation of osteoblasts through the regulation of BK channel.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cell Biology
Ji Pang, Liang Le, Yi Zhou, Renjun Tu, Qiang Hou, Dai Tsuchiya, Nancy Thomas, Yongfu Wang, Zulin Yu, Richard Alexander, Marina Thexton, Brandy Lewis, Timothy Corbin, Michael Durnin, Hua Li, Ruth Ashery-Padan, Deyue Yan, Ting Xie
Summary: This study demonstrates that NOTCH signaling in the ciliary body plays a crucial role in regulating ciliary body morphogenesis, aqueous humor secretion, and vitreous protein expression, which are important for maintaining intraocular pressure and eye structures.
Article
Cell Biology
Huo-Liang Zheng, Wen-Ning Xu, Wen-Sheng Zhou, Run-Ze Yang, Peng-Bo Chen, Tao Liu, Lei-Sheng Jiang, Sheng-Dan Jiang
Summary: Maintaining bone health requires a critical balance between bone resorption and formation. Beraprost was identified as a pivotal regulator of bone formation and resorption, promoting differentiation of bone mesenchymal stem cells through the PI3K-AKT pathway. Furthermore, the p53-Nedd4-Runx2 axis was shown to be an effective regulator of bone formation, with potential therapeutic implications for postmenopausal osteoporosis.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Austin P. Hensley, Audrey McAlinden
Summary: miRNAs are important epigenetic factors in regulating bone development, homeostasis, and repair processes by suppressing specific target genes. Studies have shown that alterations in miRNA levels or activity can lead to significant changes in cellular processes. Research has also revealed the potential therapeutic applications of miRNA regulation in various bone conditions.
Article
Biochemistry & Molecular Biology
Maria Riedel, Martin F. Berthelsen, Huiqiang Cai, Jakob Haldrup, Michael Borre, Soren R. Paludan, Henrik Hager, Mikkel H. Vendelbo, Erwin F. Wagner, Latifa Bakiri, Martin K. Thomsen
Summary: This study provides functional evidence that FOS acts as a tumor suppressor in prostate cancer progression, its deficiency leading to increased cell proliferation and oncogenic pathway alterations. Loss of FOS accelerates disease progression through accelerated proliferation and invasiveness, partly through the involvement of JUN.
Correction
Oncology
Andreas Hippe, Stephan Alexander Braun, Peter Olah, Peter Arne Gerber, Anne Schorr, Stephan Seeliger, Stephanie Holtz, Katharina Jannasch, Andor Pivarcsi, Bettina Buhren, Holger Schrumpf, Andreas Kislat, Erich Bunemann, Martin Steinhoff, Jens Fischer, Sergio A. Lira, Petra Boukamp, Peter Hevezi, Nikolas Hendrik Stoecklein, Thomas Hoffmann, Frauke Alves, Jonathan Sleeman, Thomas Bauer, Jorg Klufa, Nicole Amberg, Maria Sibilia, Albert Zlotnik, Anja Mueller-Homey, Bernhard Homey
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Mirjam A. Beck, Heinz Fischer, Lisa M. Grabner, Tamara Groffics, Mircea Winter, Simone Tangermann, Tina Meischel, Barbara Zaussinger-Haas, Patrick Wagner, Carina Fischer, Christina Folie, Julia Arand, Christian Schoefer, Bernard Ramsahoye, Sabine Lagger, Georg Machat, Gregor Eisenwort, Stephanie Schneider, Alexandra Podhornik, Michael Kothmayer, Ursula Reichart, Martin Gloesmann, Ido Tamir, Michael Mildner, Raheleh Sheibani-Tezerji, Lukas Kenner, Peter Petzelbauer, Gerda Egger, Maria Sibilia, Andrea Ablasser, Christian Seiser
Summary: DNA methylation is crucial in biological processes and the absence of DNMT1 disrupts epidermal structure and homeostasis, triggering a massive innate immune response. DNA hypomethylation in keratinocytes leads to transposon derepression, causing inflammation.
Article
Transplantation
Amelie Kurnikowski, Simon Krenn, Michal J. Lewandowski, Elisabeth Schwaiger, Allison Tong, Kitty J. Jager, Juan Jesus Carrero, Manfred Hecking, Sebastian Hoedlmoser
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Biology
Thomas Bauer, Daniela Gubi, Joerg Klufa, Philipp Novoszel, Martin Holcmann, Maria Sibilia
Summary: The epidermal growth factor (EGFR) on keratinocytes plays a crucial role in protecting the skin barrier, and its dysfunction may lead to skin diseases resembling atopic dermatitis. The AP-1 family of transcription factors is involved in TSLP production during early stages of skin inflammation, with inhibition of the c-Jun N-terminal kinase pathway reducing TSLP release. Targeting AP-1 may offer a novel therapeutic approach for atopic-like skin inflammation.
Article
Multidisciplinary Sciences
Hao Xie, Christoph Heier, Xia Meng, Latifa Bakiri, Isabella Pototschnig, Zhiyuan Tang, Silvia Schauer, Vanessa J. Baumgartner, Gernot F. Grabner, Gernot Schabbauer, Heimo Wolinski, Graham R. Robertson, Gerald Hoefler, Wenwen Zeng, Erwin F. Wagner, Martina Schweiger, Rudolf Zechner
Summary: This study shows that cachexigenic tumors activate type 2 immunity in cachectic white adipose tissue (WAT), leading to an increase in sympathetic activity and induction of WAT browning. The targeting of macrophage-sympathetic neuron cross-talk within adipose tissue could be a promising therapeutic approach for cachexia in cancer patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Rheumatology
Liliana F. Mellor, Nuria Gago-Lopez, Latifa Bakiri, Felix N. Schmidt, Bjorn Busse, Simon Rauber, Maria Jimenez, Diego Megias, Sergio Oterino-Soto, Ricardo Sanchez-Prieto, Sergei Grivennikov, Xinzhu Pu, Julia Oxford, Andreas Ramming, Georg Schett, Erwin F. Wagner
Summary: Keratinocyte-derived S100A9 plays a regulatory role in psoriatic skin and joint disease. In addition, S100A9 and CP have the potential to serve as biomarkers for identifying Ps patients at risk of developing PsA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Urology & Nephrology
Oskar Swartling, Yuanhang Yang, Catherine M. Clase, Edouard L. Fu, Manfred Hecking, Sebastian Hoedlmoser, Ylva Trolle-Lagerros, Marie Evans, Juan J. Carrero
Summary: This study evaluated the sex differences in CKD patients and found that the disparities may be explained by differences in healthcare.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Engineering, Biomedical
Daniel Schneditz, Sebastian Mussnig, Simon Krenn, Manfred Hecking
Summary: The current estimation of body fluid volumes in hemodialysis patients using bioimpedance analysis assumes constant specific electrical characteristics of biological tissues despite a large variation in plasma Na+ concentrations [Na+]. This study examined the potential effect of variable [Na+] on bioimpedance-derived volume overload and found that the increase in volume overload was abolished when the same bioimpedance data were analyzed under revised conditions that account for differences in tissue electrical properties using individual [Na+]. The overestimation in extracellular volume overload caused by the variation in [Na+] may become important when comparing data of larger patient groups.
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
(2023)
Editorial Material
Cell Biology
Latifa Bakiri
Summary: Osteoclasts degrade bone by using Cathepsin K and two metalloproteinases, MMP9 and MMP14. In addition to cleaving collagen, Zhu et al. (2023. J. Cell Biol.) have discovered that MMP9 and MMP14 also proteolyze galectin-3 on the cell surface. This process drives a galectin-3/LRP1 signaling axis that supports the hard tissue-resorbing function of osteoclasts.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Nutrition & Dietetics
Sebastian Mussnig, Michael Schmiedecker, Maximilian Waller, Janosch Niknam, Christopher Paschen, Daniel Schneditz, Manfred Hecking, Simon Krenn
Summary: This study aimed to compare the differences between two versions (3.2.5 and 3.3.3) of the Body Composition Monitor (BCM) in measuring body impedance, fat and lean tissue mass, fluid compartments, and overhydration. The results showed significant differences between the two versions of the BCM in terms of overhydration, with the newer version 3.3.3 tending to measure less overhydration. Therefore, it is important to check the version of the BCM device and use devices of the same version for each patient to ensure better within-patient consistency.
Article
Urology & Nephrology
Patrizia Natale, Manfred Hecking, Amelie Kurnikowski, Nicole Scholes-Robertson, Juan Jesus Carrero, Germaine Wong, Giovanni Strippoli, Allison Jaure
Summary: There is a gender disparity in access to kidney transplantation, with women being 20% less likely to receive a transplant compared to men across different backgrounds and socioeconomics. Nephrologists perceive that this disparity is exacerbated by gender norms, stigma, prejudice, and educational and financial disadvantages faced by women.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Transplantation
Maximilian Waller, Simon Krenn, Sebastian Mussnig, Michael Schmiedecker, Janosch Niknam-Saeidi, Christopher C. Mayer, Peter Wabel, Daniel Schneditz, Charles Chazot, Manfred Hecking
Summary: This article provides a video link to watch the related content.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Nicholas C. Chesnaye, Juan Jesus Carrero, Manfred Hecking, Kitty J. Jager
Summary: Improved understanding of gender differences in kidney disease epidemiology, management, and outcomes is crucial to provide better care to patients. Women have a higher prevalence of early-stage chronic kidney disease, while men have a higher risk of kidney function decline, kidney failure, and cardiovascular disease. However, the protective effect of female sex diminishes with disease progression. Women are less likely to be diagnosed and treated for kidney disease and have lower health-related quality of life. They face more barriers to access the transplant waiting list but have better survival after transplantation.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Urology & Nephrology
Daniel Schneditz, Peter Hofmann, Simon Krenn, Maximilian Waller, Sebastian Mussnig, Manfred Hecking
Summary: Short-term variability in body mass is common but data on this variability is limited. For individuals with impaired volume homeostasis, such as kidney failure patients, body mass variability should be taken into consideration during therapy. The study found that body mass relative differences remained constant over time.