Targeting lactate metabolism for cancer immunotherapy - a matter of precision

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

(2022) Christopher Ronald Funk et al.   BLOOD

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

(2022) Shogo Kumagai et al.   CANCER CELL

Engineering T-cells with chimeric antigen receptors to combat hematological cancers: an update on clinical trials

(2022) Maria Ormhøj et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

(2022) Mathias Wenes et al.   Cell Metabolism

LDHB Overexpression Can Partially Overcome T Cell Inhibition by Lactic Acid

(2022) Sonja-Maria Decking et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical relevance of tumour-associated macrophages

(2022) Mikael J. Pittet et al.   Nature Reviews Clinical Oncology

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

(2022) Ilaria Elia et al.   Cell Metabolism

Carbon source availability drives nutrient utilization in CD8+ T cells

(2022) Irem Kaymak et al.   Cell Metabolism

c-Myb redefines the hierarchy of stem-like T cells

(2022) Christoph Heuser et al.   NATURE IMMUNOLOGY

Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function

(2022) Giulia Notarangelo et al.   SCIENCE

Lactic acid and lactate: revisiting the physiological roles in the tumor microenvironment

(2022) Petya Apostolova et al.   TRENDS IN IMMUNOLOGY

Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

(2022) Qiang Feng et al.   Nature Communications

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

(2021) Ke Xu et al.   SCIENCE

CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours

(2021) Roberta Zappasodi et al.   NATURE

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

(2021) McLane J. Watson et al.   NATURE

Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma

(2021) Jason Miska et al.   Science Advances

A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting

(2021) Yanmei He et al.   Science Advances

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

How metabolism bridles cytotoxic CD8+ T cells through epigenetic modifications

(2021) Heleen H. Van Acker et al.   TRENDS IN IMMUNOLOGY

The Complex Integration of T-cell Metabolism and Immunotherapy

(2021) Matthew Z. Madden et al.   Cancer Discovery

Inhibition of LDH-A by Oxamate Enhances the Efficacy of Anti-PD-1 Treatment in an NSCLC Humanized Mouse Model

(2021) Tianyun Qiao et al.   Frontiers in Oncology

Prognostic Significance of SUVmax Combined With Lactate Dehydrogenase in Advanced Lung Cancer Patients Treated With Immune Checkpoint Inhibitor Plus Chemotherapy: A Retrospective Study

(2021) Linping Ke et al.   Frontiers in Oncology

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

(2021) Yugang Guo et al.   NATURE IMMUNOLOGY

FDG PET biomarkers for prediction of survival in metastatic melanoma prior to anti-PD1 immunotherapy

(2021) A. Flaus et al.   Scientific Reports

Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition

(2021) Catherine Vander Linden et al.   Cell Reports

Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function

(2021) Sam Sheppard et al.   Cell Reports

Prognostic value of 2-[18F]FDG PET-CT in metastatic melanoma patients receiving immunotherapy

(2021) Gregor Schweighofer-Zwink et al.   EUROPEAN JOURNAL OF RADIOLOGY

Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

(2021) Joris L. Vos et al.   Nature Communications

Lactate supports a metabolic-epigenetic link in macrophage polarization

(2021) Jordan T. Noe et al.   Science Advances

Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration

(2020) Mounia Beloueche-Babari et al.   BRITISH JOURNAL OF CANCER

Saccharide analog, 2‐deoxy‐ d ‐glucose enhances 4‐1BB‐mediated antitumor immunity via PD‐L1 deglycosylation

(2020) Bareun Kim et al.   MOLECULAR CARCINOGENESIS

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity

(2020) Dalton Hermans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

(2020) Nobu Oshima et al.   Cell Reports

18F-fluorodeoxyglucose positron emission tomography correlates with tumor immunometabolic phenotypes in resected lung cancer

(2020) Kyle G. Mitchell et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8 + T cells

(2020) Connor J. Dwyer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The immunological Warburg effect: Can a metabolic‐tumor‐stroma score (MeTS) guide cancer immunotherapy?

(2020) Peter J. Siska et al.   IMMUNOLOGICAL REVIEWS

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

(2020) Hongling Huang et al.   IMMUNOLOGICAL REVIEWS

Tumor‐Targeted Inhibition of Monocarboxylate Transporter 1 Improves T‐Cell Immunotherapy of Solid Tumors

(2020) Tongyi Huang et al.   Advanced Healthcare Materials

Metabolic Modulation of the Tumor Microenvironment Leads to Multiple Checkpoint Inhibition and Immune Cell Infiltration

(2020) David Kolb et al.   ACS Nano

Dynamics in protein translation sustaining T cell preparedness

(2020) Tobias Wolf et al.   NATURE IMMUNOLOGY

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties

(2020) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single-cell metabolic profiling of human cytotoxic T cells

(2020) Felix J. Hartmann et al.   NATURE BIOTECHNOLOGY

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

(2020) Hao Wu et al.   Nature Communications

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

(2020) Qin Wu et al.   Nature Communications

Nanoparticle-mediated delivery of 2-deoxy-D-glucose induces antitumor immunity and cytotoxicity in liver tumors in mice

(2020) Kyo Sasaki et al.   Cellular and Molecular Gastroenterology and Hepatology

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response

(2020) Emma McCann et al.   Translational Oncology

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

(2020) William J. Quinn et al.   Cell Reports

Tumor-associated macrophages enhance tumor hypoxia and aerobic glycolysis

(2019) Hoibin Jeong et al.   CANCER RESEARCH

An evolutionary perspective on immunometabolism

(2019) Andrew Wang et al.   SCIENCE

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

(2019) Alanna M. Cameron et al.   NATURE IMMUNOLOGY

Lactate secreted by cervical cancer cells modulates macrophage phenotype

(2019) Simone Cardozo Stone et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting hypoxia-induced carbonic anhydrase IX enhances immune checkpoint blockade locally and systemically

(2019) Shawn C Chafe et al.   Cancer Immunology Research

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

(2019) Will Bailis et al.   NATURE

mTOR: Role in cancer, metastasis and drug resistance

(2019) Avaniyapuram Kannan Murugan   SEMINARS IN CANCER BIOLOGY

The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells

(2019) Taisuke Kondo et al.   CANCER RESEARCH

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

The role of interleukin-17 in tumor development and progression

(2019) Junjie Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

(2019) Kathrin Renner et al.   Cell Reports

Metabolic Consequences of T-cell Costimulation in Anticancer Immunity

(2019) Alvaro Teijeira et al.   Cancer Immunology Research

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

(2018) Tina Cascone et al.   Cell Metabolism

CD38-NAD + Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

(2018) Shilpak Chatterjee et al.   Cell Metabolism

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

(2018) Wei Li et al.   Cell Metabolism

Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review

(2018) Zhe Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

(2018) Ashley V. Menk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PI3K orchestration of the in vivo persistence of chimeric antigen receptor-modified T cells

(2018) Wenting Zheng et al.   LEUKEMIA

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth

(2018) Ilenia Pacella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

(2018) Jake S. O’Donnell et al.   SEMINARS IN CANCER BIOLOGY

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

(2018) Sharanya Sivanand et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cancer-associated fibroblasts enhance tumor 18F-FDG uptake and contribute to the intratumor heterogeneity of PET-CT

(2018) Chengfang Shangguan et al.   Theranostics

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions

(2018) Ashley V. Menk et al.   Cell Reports

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

(2018) Concetta Quintarelli et al.   OncoImmunology

Teaching an old dog new tricks: next-generation CAR T cells

(2018) Nicholas Tokarew et al.   BRITISH JOURNAL OF CANCER

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages

(2018) Toszka Bohn et al.   NATURE IMMUNOLOGY

Lactate-mediated acidification of tumor microenvironment induces apoptosis of liver-resident NK cells in colorectal liver metastasis

(2018) Cathal Harmon et al.   Cancer Immunology Research

Pseudoprogression in Previously Treated Patients with Non–Small Cell Lung Cancer Who Received Nivolumab Monotherapy

(2018) Daichi Fujimoto et al.   Journal of Thoracic Oncology

Prognostic factors and outcomes in metastatic uveal melanoma treated with programmed cell death-1 or combined PD-1/cytotoxic T-lymphocyte antigen-4 inhibition

(2017) Markus V. Heppt et al.   EUROPEAN JOURNAL OF CANCER

Reversal of tumor acidosis by systemic buffering reactivates NK cells to express IFN-γ and induces NK cell-dependent lymphoma control without other immunotherapies

(2017) Johann Pötzl et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic reprogramming of human CD8+memory T cells through loss of SIRT1

(2017) Mark Y. Jeng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis

(2017) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

Innate Lymphoid Cell Immunometabolism

(2017) Timothy E. O'Sullivan et al.   JOURNAL OF MOLECULAR BIOLOGY

T memory stem cells in health and disease

(2017) Luca Gattinoni et al.   NATURE MEDICINE

Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development

(2017) Lindsay Wilde et al.   SEMINARS IN ONCOLOGY

Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy

(2017) Ryan Urak et al.   Journal for ImmunoTherapy of Cancer

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

(2016) Madhusudhanan Sukumar et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

(2016) Holger Siebeneicher et al.   ChemMedChem

Lactate at the crossroads of metabolism, inflammation, and autoimmunity

(2016) Valentina Pucino et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

Constitutive Glycolytic Metabolism Supports CD8 + T Cell Effector Memory Differentiation during Viral Infection

(2016) Anthony T. Phan et al.   IMMUNITY

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Cutting Edge: Murine Mast Cells Rapidly Modulate Metabolic Pathways Essential for Distinct Effector Functions

(2016) Binh Phong et al.   JOURNAL OF IMMUNOLOGY

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Toll like receptor mediated immune stimulation can be visualized in vivo by [ 18 F]FDG-PET

(2016) Stefanie Pektor et al.   NUCLEAR MEDICINE AND BIOLOGY

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

NaHCO3 enhances the antitumor activities of cytokine-induced killer cells against hepatocellular carcinoma HepG2 cells

(2016) Ya Hong Yuan et al.   Oncology Letters

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy

(2016) K. Okkenhaug et al.   Cancer Discovery

Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner

(2016) Lianjun Zhang et al.   Cell Reports

The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

(2015) Cara J. Valvona et al.   BRAIN PATHOLOGY

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

(2015) Julie Helft et al.   IMMUNITY

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

(2015) Kristen N. Pollizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

Mito-DCA: A Mitochondria Targeted Molecular Scaffold for Efficacious Delivery of Metabolic Modulator Dichloroacetate

(2014) Rakesh K. Pathak et al.   ACS Chemical Biology

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

(2014) A. B. van der Waart et al.   BLOOD

Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics

(2014) J. G. Crompton et al.   CANCER RESEARCH

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Tumor Microenvironment and Metabolic Synergy in Breast Cancers: Critical Importance of Mitochondrial Fuels and Function

(2014) Ubaldo Martinez-Outschoorn et al.   SEMINARS IN ONCOLOGY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

(2013) Joseph G. Crompton et al.   IMMUNOLOGICAL REVIEWS

Rapamycin-resistant effector T-cell therapy

(2013) Daniel H. Fowler   IMMUNOLOGICAL REVIEWS

How Metabolism Generates Signals during Innate Immunity and Inflammation

(2013) Anne F. McGettrick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

(2013) Z. Husain et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

(2012) Yasir H. Ibrahim et al.   Cancer Discovery

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality

(2011) D. A. Chan et al.   Science Translational Medicine

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Immunopotentiating effect of proton pump inhibitor pantoprazole in a lymphoma-bearing murine host: Implication in antitumor activation of tumor-associated macrophages

(2010) Naveen Kumar Vishvakarma et al.   IMMUNOLOGY LETTERS

Warburg phenotype in renal cell carcinoma: High expression of glucose-transporter 1 (GLUT-1) correlates with low CD8+ T-cell infiltration in the tumor

(2010) Katrin Singer et al.   INTERNATIONAL JOURNAL OF CANCER

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

(2009) Angelo De Milito et al.   INTERNATIONAL JOURNAL OF CANCER

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Targeting AKT Signaling Sensitizes Cancer to Cellular Immunotherapy

(2008) P. S. Hahnel et al.   CANCER RESEARCH