Oncometabolite d -2HG alters T cell metabolism to impair CD8 + T cell function

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

(2021) Nathan D. Mathewson et al.   CELL

MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging

(2021) Denis Schapiro et al.   NATURE METHODS

rMSIproc: an R package for mass spectrometry imaging data processing

(2020) Pere Ràfols et al.   BIOINFORMATICS

Metabolic changes related to the IDH1 mutation in gliomas preserve TCA‐cycle activity: An investigation at the protein level

(2020) Lennard J. M. Dekker et al.   FASEB JOURNAL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

(2020) William J. Quinn et al.   Cell Reports

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

(2020) Jefte M. Drijvers et al.   Cancer Immunology Research

Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens

(2019) Bas Weenink et al.   Scientific Reports

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

(2018) Lukas Bunse et al.   NATURE MEDICINE

Modeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system

(2018) Andreas Linninger et al.   NEURO-ONCOLOGY

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

(2018) Jia-Ren Lin et al.   eLife

Regulation of CD8+ T Cells and Antitumor Immunity by Notch Signaling

(2018) Shin-ichi Tsukumo et al.   Frontiers in Immunology

Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas

(2017) Gary Kohanbash et al.   JOURNAL OF CLINICAL INVESTIGATION

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

Correlation of immune phenotype with IDH mutation in diffuse glioma

(2017) Anna Sophie Berghoff et al.   NEURO-ONCOLOGY

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions

(2016) Stephen P. Burr et al.   Cell Metabolism

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

(2016) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Hyperpolarized 13 C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

(2016) Myriam M. Chaumeil et al.   NeuroImage-Clinical

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Pretreatment d-2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia

(2015) J Balss et al.   LEUKEMIA

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Mitochondrial 2-hydroxyglutarate metabolism

(2014) Martin K.M. Engqvist et al.   MITOCHONDRION

Metabolic Reprogramming towards Aerobic Glycolysis Correlates with Greater Proliferative Ability and Resistance to Metabolic Inhibition in CD8 versus CD4 T Cells

(2014) Yilin Cao et al.   PLoS One

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

(2013) J.-A. Losman et al.   GENES & DEVELOPMENT

Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate

(2013) Ovidiu C. Andronesi et al.   JOURNAL OF CLINICAL INVESTIGATION

Lactate dehydrogenase A silencing in IDH mutant gliomas

(2013) Charles Chesnelong et al.   NEURO-ONCOLOGY

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metabolic switching and fuel choice during T-cell differentiation and memory development

(2012) Gerritje J. W. Windt et al.   IMMUNOLOGICAL REVIEWS

Autocrine IFN-  Promotes Naive CD8 T Cell Differentiation and Synergizes with IFN-  To Stimulate Strong Function

(2012) J. M. Curtsinger et al.   JOURNAL OF IMMUNOLOGY

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

(2012) O. C. Andronesi et al.   Science Translational Medicine

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells

(2010) Simon J. Waddell et al.   PLoS One

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

(2008) Candace M. Cham et al.   EUROPEAN JOURNAL OF IMMUNOLOGY