An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells

Killing SCLC: insights into how to target a shapeshifting tumor

(2022) Kate D. Sutherland et al.   GENES & DEVELOPMENT

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

(2021) Carl M. Gay et al.   CANCER CELL

Intratumoral heterogeneity in cancer progression and response to immunotherapy

(2021) Ilio Vitale et al.   NATURE MEDICINE

Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers

(2021) Sarah A. Head et al.   PLOS BIOLOGY

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

(2020) Daniel J. Coleman et al.   NEOPLASIA

SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion

(2020) Vanessa M. Conn et al.   Cells

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

(2019) Wen Shen et al.   NATURE BIOTECHNOLOGY

Intratumoral Heterogeneity: More Than Just Mutations

(2019) Kunihiko Hinohara et al.   TRENDS IN CELL BIOLOGY

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

(2019) Masahito Shimojo et al.   Scientific Reports

Neuroendocrine Differentiation of Prostate Cancer—An Intriguing Example of Tumor Evolution at Play

(2019) Patel et al.   Cancers

Clinical features of neuroendocrine prostate cancer

(2019) Vincenza Conteduca et al.   EUROPEAN JOURNAL OF CANCER

Small cell lung cancer heterogeneity: elevated a Notch above the Rest!

(2018) Khaled A. Hassan   Journal of Thoracic Disease

SRRM4 gene expression correlates with neuroendocrine prostate cancer

(2018) Yinan Li et al.   PROSTATE

A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network

(2018) Ahn R. Lee et al.   EBioMedicine

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

(2017) Jing Shan Lim et al.   NATURE

Drug development in the era of precision medicine

(2017) Sarah A. Dugger et al.   NATURE REVIEWS DRUG DISCOVERY

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

(2017) Xiulong Shen et al.   NUCLEIC ACIDS RESEARCH

Establishment of a neuroendocrine prostate cancer model driven by the RNA splicing factor SRRM4

(2017) Yinan Li et al.   Oncotarget

Antisense Oligonucleotides Targeting Y-Box Binding Protein-1 Inhibit Tumor Angiogenesis by Downregulating Bcl-xL-VEGFR2/-Tie Axes

(2017) Kiyoko Setoguchi et al.   Molecular Therapy-Nucleic Acids

ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs

(2016) Mark D. Borromeo et al.   Cell Reports

Pituitary adenylate cyclase-activating polypeptide is regulated by alternative splicing of transcriptional repressor REST/NRSF in nerve injury

(2015) Yoshie Shudo et al.   LIFE SCIENCES

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Tumor Cell Heterogeneity in Small Cell Lung Cancer (SCLC): Phenotypical and Functional Differences Associated with Epithelial-Mesenchymal Transition (EMT) and DNA Methylation Changes

(2014) Alexander Krohn et al.   PLoS One

The Small Cell Lung Cancer-Specific Isoform of RE1-Silencing Transcription Factor (REST) Is Regulated By Neural-Specific Ser/Arg Repeat-Related Protein of 100 kDa (nSR100)

(2013) Masahito Shimojo et al.   MOLECULAR CANCER RESEARCH

Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency

(2012) Aiko Yahara et al.   CHEMBIOCHEM

Cross-Regulation between an Alternative Splicing Activator and a Transcription Repressor Controls Neurogenesis

(2011) Bushra Raj et al.   MOLECULAR CELL

The Transcription Factor REST Is Lost in Aggressive Breast Cancer

(2010) Matthew P. Wagoner et al.   PLoS Genetics

Genome-wide identification of target genes repressed by the zinc finger transcription factor REST/NRSF in the HEK 293 cell line

(2009) Z. Liu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Alternative Splicing in Lung Cancer

(2009) Ruben Pio et al.   Journal of Thoracic Oncology