Effects of shear stress on vascular endothelial functions in atherosclerosis and potential therapeutic approaches

Endothelial Mechanosensors for Atheroprone and Atheroprotective Shear Stress Signals

(2022) Hui Li et al.   Journal of Inflammation Research

Endothelial shear stress signal transduction and atherogenesis: From mechanisms to therapeutics

(2022) Lei He et al.   PHARMACOLOGY & THERAPEUTICS

Activation of GPR30 with G1 inhibits oscillatory shear stress-induced adhesion of THP-1 monocytes to HAECs by increasing KLF2

(2021) Chi Chen et al.   Aging-US

Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE−/- mice

(2021) Han Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heparan sulfate proteoglycan glypican-1 and PECAM-1 cooperate in shear-induced endothelial nitric oxide production

(2021) Anne Marie W. Bartosch et al.   Scientific Reports

Melatonin attenuates low shear stress‑induced pyroptosis and endothelial cell dysfunction via the RORα/miR‑223/STAT‑3 signalling pathway

(2021) Sui Yi et al.   Experimental and Therapeutic Medicine

Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary cilia

(2021) Tetsuro Ishii et al.   Redox Biology

Comparative study of the effects of cigarette smoke versus next generation tobacco and nicotine product extracts on endothelial function

(2021) Sindy Giebe et al.   Redox Biology

Targeting mitochondria-inflammation circle by renal denervation reduces atheroprone endothelial phenotypes and atherosclerosis

(2021) Zhuqing Li et al.   Redox Biology

Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis

(2020) Yuta Takagaki et al.   Autophagy

Salidroside Decreases Atherosclerosis Plaque Formation via Inhibiting Endothelial Cell Pyroptosis

(2020) Sha-Sha Xing et al.   INFLAMMATION

Epigenetic response of endothelial cells to different wall shear stress magnitudes: A report of new mechano‐miRNAs

(2020) Sherif Rashad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endothelial Transient Receptor Potential Channels and Vascular Remodeling: Extracellular Ca2 + Entry for Angiogenesis, Arteriogenesis and Vasculogenesis

(2020) Sharon Negri et al.   Frontiers in Physiology

Upregulation of angiotensin converting enzyme 2 by shear stress reduced inflammation and proliferation in vascular endothelial cells

(2020) Jiantao Song et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exercise and Coronary Atherosclerosis

(2020) Vincent L. Aengevaeren et al.   CIRCULATION

Swimming exercise activates aortic autophagy and limits atherosclerosis in ApoE−/− mice

(2020) Yang Li et al.   Obesity Research & Clinical Practice

The improvement of the shear stress and oscillatory shear index of coronary arteries during Enhanced External Counterpulsation in patients with coronary heart disease

(2020) Ling Xu et al.   PLoS One

TAVI Represents an Anti-Inflammatory Therapy via Reduction of Shear Stress Induced, Piezo-1-Mediated Monocyte Activation

(2020) Sara Baratchi et al.   CIRCULATION

Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

(2020) Chenghu Zhang et al.   CIRCULATION RESEARCH

FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis

(2020) Zhaolin Zeng et al.   EXPERIMENTAL CELL RESEARCH

Low shear stress regulates vascular endothelial cell pyroptosis through miR‐181b‐5p/STAT‐3 axis

(2020) Xiangshan Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

(2020) Laura Stanicek et al.   Communications Biology

Inactivation of Apoc3 by CRISPR/Cas9 Protects Against Atherosclerosis in Hamsters

(2020) Mengmeng Guo et al.   CIRCULATION RESEARCH

Shear stress turns on the primary cilium and lipophagy

(2020) Nuria Martinez-Lopez et al.   NATURE CELL BIOLOGY

NF-κB inhibition prevents acute shear stress-induced inflammation in the saphenous vein graft endothelium

(2020) Alexander O. Ward et al.   Scientific Reports

Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy

(2020) Qinghai Meng et al.   Journal of Advanced Research

PCSK9 and atherosclerosis: Looking beyond LDL regulation

(2020) Rosetta Ragusa et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Shear stress induces pathological changes in endothelial cells through Piezo1 activation of TRPV4

(2020) Sandip M. Swain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shear stress activates mitochondrial oxidative phosphorylation by reducing plasma membrane cholesterol in vascular endothelial cells

(2020) Kimiko Yamamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycocalyx sialic acids regulate Nrf2-mediated signaling by fluid shear stress in human endothelial cells

(2020) Paraskevi-Maria Psefteli et al.   Redox Biology

The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age

(2019) Ashley E. Walker et al.   Scientific Reports

Oscillating flow promotes inflammation through the TLR2–TAK1–IKK2 signalling pathway in human umbilical vein endothelial cell (HUVECs)

(2019) Feng Wang et al.   LIFE SCIENCES

KLF2 regulates eNOS uncoupling via Nrf2/HO-1 in endothelial cells under hypoxia and reoxygenation

(2019) WeiDang Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Role of autophagy in atherosclerosis: foe or friend?

(2019) Mehdi Hassanpour et al.   Journal of Inflammation-London

Targeting Mechanosensitive Transcription Factors in Atherosclerosis

(2019) Niu Niu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Macrophage Death as a Pharmacological Target in Atherosclerosis

(2019) Wim Martinet et al.   Frontiers in Pharmacology

Triple-Targeting Delivery of CRISPR/Cas9 to Reduce the Risk of Cardiovascular Diseases

(2019) Lingmin Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Shear stress–induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure

(2019) Andras Iring et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

(2019) Celine Souilhol et al.   Nature Reviews Cardiology

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long Noncoding RNAs of the Arterial Wall as Therapeutic Agents and Targets in Atherosclerosis

(2019) Lesca M. Holdt et al.   THROMBOSIS AND HAEMOSTASIS

Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation

(2019) Win M. Tun et al.   Scientific Reports

A Modified Parallel Plate Flow Chamber to Study Local Endothelial Response to Recirculating Disturbed Flow

(2019) Jason Sedlak et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The metalloproteinase ADAM15 is upregulated by shear stress and promotes survival of endothelial cells

(2019) Aaron Babendreyer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PCSK9 and inflammation: role of shear stress, pro-inflammatory cytokines, and LOX-1

(2019) Zufeng Ding et al.   CARDIOVASCULAR RESEARCH

Coxsackievirus and adenovirus receptor mediates the responses of endothelial cells to fluid shear stress

(2019) Jihwa Chung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Piezo Ion Channels in Cardiovascular Mechanobiology

(2019) Dominique Douguet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation

(2018) Jun-Xia Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear factor E2-related factor 2 deficiency impairs atherosclerotic lesion development but promotes features of plaque instability in hypercholesterolaemic mice

(2018) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy

(2018) Zufeng Ding et al.   CARDIOVASCULAR RESEARCH

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Laminar shear stress promotes mitochondrial homeostasis in endothelial cells

(2018) Li-Hong Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Local Low Shear Stress and Endothelial Dysfunction in Patients With Nonobstructive Coronary Atherosclerosis

(2018) Gerasimos Siasos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Coronary and carotid atherosclerosis in asymptomatic male marathon runners

(2018) C. Burgstahler et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Shear stress augments mitochondrial ATP generation that triggers ATP release and Ca2+ signaling in vascular endothelial cells

(2018) Kimiko Yamamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Effects of Endurance Exercise and Diet on Atherosclerosis in Young and Aged ApoE–/– and Wild-Type Mice

(2018) Bojana Jakic et al.   GERONTOLOGY

Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

(2018) Hojin Kang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PCSK9 inhibitors: clinical evidence and implementation

(2018) Marc S. Sabatine   Nature Reviews Cardiology

Exposure to endosulfan increases endothelial permeability by transcellular and paracellular pathways in relation to cardiovascular diseases

(2017) Dan Xu et al.   ENVIRONMENTAL POLLUTION

Animal models of atherosclerosis

(2017) Besa Emini Veseli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

High wall shear stress and high-risk plaque: an emerging concept

(2017) Parham Eshtehardi et al.   INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING

Primary Cilium-Dependent Signaling Mechanisms

(2017) Rajasekharreddy Pala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Extreme Endurance Exercise and Progressive Coronary Artery Disease

(2017) Jeffrey Lin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial

(2017) Robert P Giugliano et al.   LANCET

Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion

(2017) Aaron Babendreyer et al.   MEDIATORS OF INFLAMMATION

Low shear stress-induced autophagy alleviates cell apoptosis in HUVECs

(2017) Guo Dong et al.   Molecular Medicine Reports

Fluvastatin inhibits AGE-induced cell proliferation and migration via an ERK5-dependent Nrf2 pathway in vascular smooth muscle cells

(2017) Ae-Rang Hwang et al.   PLoS One

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim

(2017) Yao Li et al.   Scientific Reports

Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells

(2017) Yanni Xu et al.   Scientific Reports

Suppression of TAK1 pathway by shear stress counteracts the inflammatory endothelial cell phenotype induced by oxidative stress and TGF-β1

(2017) Ee Soo Lee et al.   Scientific Reports

Shear Stress Regulates TRPV4 Channel Clustering and Translocation from Adherens Junctions to the Basal Membrane

(2017) Sara Baratchi et al.   Scientific Reports

Effects of shear stress on endothelial cells: go with the flow

(2016) D. A. Chistiakov et al.   Acta Physiologica

Mechanotransduction of the endothelial glycocalyx mediates nitric oxide production through activation of TRP channels

(2016) Matthew A. Dragovich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of endothelial mechanosensitive genes in atherosclerosis and omics approaches

(2016) Rachel D. Simmons et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Zebrafish Model for Functional Screening of Flow-Responsive GenesHighlights

(2016) Jovana Serbanovic-Canic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Endothelial primary cilia inhibit atherosclerosis

(2016) Colin Dinsmore et al.   EMBO REPORTS

Endothelial PECAM-1 and its function in vascular physiology and atherogenic pathology

(2016) Dimitry A. Chistiakov et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease

(2016) Dimitry A. Chistiakov et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Supervised exercise training in peripheral arterial disease increases vascular shear stress and profunda femoral artery diameter

(2016) Jörn F Dopheide et al.   European Journal of Preventive Cardiology

Influence of shear stress magnitude and direction on atherosclerotic plaque composition

(2016) Ryan M. Pedrigi et al.   Royal Society Open Science

Training-induced anti-atherosclerotic effects are associated with increased vascular PPARgamma expression in apolipoprotein E-deficient mice

(2015) J. Szostak et al.   Acta Physiologica

Shear stress-induced mitochondrial biogenesis decreases the release of microparticles from endothelial cells

(2015) Ji-Seok Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Hemodynamic Shear Stress via ROS Modulates PCSK9 Expression in Human Vascular Endothelial and Smooth Muscle Cells and Along the Mouse Aorta

(2015) Zufeng Ding et al.   ANTIOXIDANTS & REDOX SIGNALING

Shear stress-induced atherosclerotic plaque composition in ApoE −/− mice is modulated by connexin37

(2015) A. Pfenniger et al.   ATHEROSCLEROSIS

Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII

(2015) Haibo Li et al.   CARDIOVASCULAR RESEARCH

MicroRNA Mediation of Endothelial Inflammatory Response to Smooth Muscle Cells and Its Inhibition by Atheroprotective Shear StressNovelty and Significance

(2015) Li-Jing Chen et al.   CIRCULATION RESEARCH

Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles

(2015) Nicolas Jaé et al.   FEBS LETTERS

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

ERK5/HDAC5-mediated, resveratrol-, and pterostilbene-induced expression of MnSOD in human endothelial cells

(2015) Woting Gan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

(2015) Jennifer G. Robinson et al.   NEW ENGLAND JOURNAL OF MEDICINE

miRNAs in atherosclerotic plaque initiation, progression, and rupture

(2015) Ioannis Andreou et al.   TRENDS IN MOLECULAR MEDICINE

Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression

(2015) J Liu et al.   Cell Death & Disease

The Antithrombotic Effects of Statins

(2014) A. Phillip Owens et al.   Annual Review of Medicine

Mechanoresponsive Networks Controlling Vascular Inflammation

(2014) Matthew T. Bryan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Flow-Sensitive microRNAs in Endothelial Dysfunction and Atherosclerosis

(2014) Sandeep Kumar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel

(2014) Juan Du et al.   FASEB JOURNAL

Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents

(2014) Nhat-Tu Le et al.   JOURNAL OF IMMUNOLOGY

Rapamycin Attenuates Endothelial Apoptosis Induced by Low Shear Stress via mTOR and Sestrin1 Related Redox Regulation

(2014) Junxia Zhang et al.   MEDIATORS OF INFLAMMATION

The Adaptive Remodeling of Endothelial Glycocalyx in Response to Fluid Shear Stress

(2014) Ye Zeng et al.   PLoS One

Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells

(2014) Takashi Maejima et al.   PLoS One

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial mechanosensors: the gatekeepers of vascular homeostasis and adaptation under mechanical stress

(2014) QiuPing Deng et al.   Science China-Life Sciences

Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: Implications for cell migration

(2014) Daniel E Conway et al.   Cell Adhesion & Migration

The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment

(2013) Matthew Harrison et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo

(2013) Peter F. Davies et al.   CARDIOVASCULAR RESEARCH

Role of caveolae in shear stress-mediated endothelium-dependent dilation in coronary arteries

(2013) Qiang Chai et al.   CARDIOVASCULAR RESEARCH

The absence of macrophage Nrf2 promotes early atherogenesis

(2013) Anna-Kaisa Ruotsalainen et al.   CARDIOVASCULAR RESEARCH

Regulation of Vascular Smooth Muscle Cell Turnover by Endothelial Cell–Secreted MicroRNA-126

(2013) Jing Zhou et al.   CIRCULATION RESEARCH

Biomechanical regulation of vascular smooth muscle cell functions: from in vitro to in vivo understanding

(2013) J. Qiu et al.   Journal of the Royal Society Interface

The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis

(2013) Dong Ju Son et al.   Nature Communications

Myeloid Deletion of Nuclear Factor Erythroid 2−Related Factor 2 Increases Atherosclerosis and Liver Injury

(2012) Alan R. Collins et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Flow-Regulated Endothelial S1P Receptor-1 Signaling Sustains Vascular Development

(2012) Bongnam Jung et al.   DEVELOPMENTAL CELL

Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation

(2012) Nobuhiko Harada et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of shear-stress-induced VEGF expression in endothelial cell survival

(2012) Nathaniel G. dela Paz et al.   JOURNAL OF CELL SCIENCE

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells

(2011) Chih-Wen Ni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Development of an Endothelial–Smooth Muscle Cell Coculture Model Using Phenotype-Controlled Smooth Muscle Cells

(2011) Naoya Sakamoto et al.   ANNALS OF BIOMEDICAL ENGINEERING

Redox Going with Vascular Shear Stress

(2011) Noriko Noguchi et al.   ANTIOXIDANTS & REDOX SIGNALING

Tannic acid is more effective than clofibrate for the elevation of hepatic β-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice

(2011) Gyeong-Min Do et al.   BRITISH JOURNAL OF NUTRITION

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis

(2011) Stefan Freigang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caveolae respond to cell stretch and contribute to stretch-induced signaling

(2011) O. L. Gervasio et al.   JOURNAL OF CELL SCIENCE

PDGF-BB and TGF-β1 on cross-talk between endothelial and smooth muscle cells in vascular remodeling induced by low shear stress

(2011) Ying-Xin Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-21 targets peroxisome proliferators-activated receptor-  in an autoregulatory loop to modulate flow-induced endothelial inflammation

(2011) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nuclear factor – kappa B pathway in atherosclerosis: A potential therapeutic target for atherothrombotic vascular disease

(2011) Burak Pamukcu et al.   THROMBOSIS RESEARCH

Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation

(2010) Wakako Takabe et al.   ANTIOXIDANTS & REDOX SIGNALING

Oscillatory Shear Stress Induces Mitochondrial Superoxide Production: Implication of NADPH Oxidase and c-Jun NH2-Terminal Kinase Signaling

(2010) Wakako Takabe et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidized Low-Density Lipoprotein-Activated c-Jun NH2-Terminal Kinase Regulates Manganese Superoxide Dismutase Ubiquitination

(2010) Wakako Takabe et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection

(2010) Berenice Barajas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial glycocalyx and coronary vascular permeability: the fringe benefit

(2010) Bernhard F. Becker et al.   BASIC RESEARCH IN CARDIOLOGY

Regulation of Hepatic ApoC3 Expression by PGC-1β Mediates Hypolipidemic Effect of Nicotinic Acid

(2010) Carlos Hernandez et al.   Cell Metabolism

Shear stress, SIRT1, and vascular homeostasis

(2010) Z. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular Mechanisms Responsible for the Atheroprotective Effects of Laminar Shear Stress

(2009) Shi Pan   ANTIOXIDANTS & REDOX SIGNALING

PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling

(2009) Zhongming Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pulsatile shear stress increased mitochondrial membrane potential: Implication of Mn-SOD

(2009) Rongsong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

(2009) Guadalupe Villarreal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype

(2009) J. Gracia-Sancho et al.   CARDIOVASCULAR RESEARCH

Shear Stress Induces Synthetic-to-Contractile Phenotypic Modulation in Smooth Muscle Cells via Peroxisome Proliferator-Activated Receptor α/δ Activations by Prostacyclin Released by Sheared Endothelial Cells

(2009) Min-Chien Tsai et al.   CIRCULATION RESEARCH

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

(2009) Wissam A. AbouAlaiwi et al.   CIRCULATION RESEARCH

Rapid changes in shear stress induce dissociation of a Gαq/11-platelet endothelial cell adhesion molecule-1 complex

(2009) Laura A. Otte et al.   JOURNAL OF PHYSIOLOGY-LONDON

Voluntary Running Suppresses Proinflammatory Cytokines and Bone Marrow Endothelial Progenitor Cell Levels in Apolipoprotein-E–Deficient Mice

(2008) Olujimi A. Ajijola et al.   ANTIOXIDANTS & REDOX SIGNALING

KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

(2008) Joost O. Fledderus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1

(2008) Surya M. Nauli et al.   CIRCULATION

Inhibition of Endothelial Nitric Oxide Synthase Activity by Proline-Rich Tyrosine Kinase 2 in Response to Fluid Shear Stress and Insulin

(2008) Beate Fisslthaler et al.   CIRCULATION RESEARCH

Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

(2008) Tadashi Yoshida et al.   CIRCULATION RESEARCH

Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress

(2008) Nick M. Matharu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

(2008) Thomas E. Sussan et al.   PLoS One

Hypothesis: arterial glycocalyx dysfunction is the first step in the atherothrombotic process

(2008) M.I.M. Noble et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis

(2007) Kim Van der Heiden et al.   ATHEROSCLEROSIS