An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction

(2011) Hasan Alsaid et al.   MAGNETIC RESONANCE IN MEDICINE

Diuretic Strategies in Patients with Acute Decompensated Heart Failure

(2011) G. Michael Felker et al.   NEW ENGLAND JOURNAL OF MEDICINE

TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling

(2011) A Fiorio Pla et al.   ONCOGENE

TRPV4 channels augment macrophage activation and ventilator-induced lung injury

(2010) Kazutoshi Hamanaka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Lung Endothelial Dysfunction in Congestive Heart Failure

(2010) Alexander Kerem et al.   CIRCULATION RESEARCH

Systolic Heart Failure

(2010) John J.V. McMurray   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

(2010) W. Everaerts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure

(2009) Scott Earley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress

(2009) Suelhem A. Mendoza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

Loop Diuretics in Acute Decompensated Heart Failure

(2009) G. Michael Felker et al.   Circulation-Heart Failure

Modulation of the Transient Receptor Potential Vanilloid Channel TRPV4 by 4α-Phorbol Esters: A Structure−Activity Study

(2009) Thomas Kjær Klausen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardiac fibroblasts have functional TRPV4 activated by 4α-phorbol 12,13-didecanoate

(2009) Noriyuki Hatano et al.   LIFE SCIENCES

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia

(2009) W. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation

(2008) Annemarieke E. Loot et al.   CARDIOVASCULAR RESEARCH

Negative-Feedback Loop Attenuates Hydrostatic Lung Edema via a cGMP-Dependent Regulation of Transient Receptor Potential Vanilloid 4

(2008) Jun Yin et al.   CIRCULATION RESEARCH

Salt Intake Augments Hypotensive Effects of Transient Receptor Potential Vanilloid 4

(2008) Feng Gao et al.   HYPERTENSION

N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I

(2008) K. S. Thorneloe et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2

(2008) R. N. Willette et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

High Vascular Pressure–Induced Lung Injury Requires P450 Epoxygenase–Dependent Activation of TRPV4

(2007) Ming-Yuan Jian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY