Article
Biochemistry & Molecular Biology
Sebastian F. Mause, Elisabeth Ritzel, Annika Deck, Felix Vogt, Elisa A. Liehn
Summary: EPCs and SMCs interact through the CXCL12-CXCR4 axis to establish an amplifying feedback loop, promoting regenerative processes and mediating SMC phenotype control to potentially maintain vascular homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Biomaterials
Meichun Wu, Min Xun, Yuping Chen
Summary: Iron-, magnesium-, or zinc-based metal vessel stents support vessel expansion and degrade away after vascular reconstruction, eliminating side effects and risks. However, their degradation alters the vascular microenvironment and induces adaptive responses of vascular cells. This review discusses how biodegradable metal stents modify vascular conditions and how vascular smooth muscle cells (VSMCs) respond to stent implantation, highlighting the importance of VSMC transformation in future stent design.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Yu Jiang, Hai-Yan Qian
Summary: Atherosclerosis (AS) is the accumulation of lipids and inflammatory debris in the arterial wall, leading to gradual occlusion of the arterial lumen. Despite therapeutic advances, AS remains the most common cause of cardiovascular diseases and the main mechanism of death and disability worldwide. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, with remarkable plasticity and involvement in various processes such as phenotypic transformation, proliferation, migration, calcification, and apoptosis. Transcription factors and complex interactions of conserved cis-regulatory elements are key in the transcriptional regulation of VSMC genes, and manipulating transcription factors can regulate the development of atherosclerotic lesions.
MOLECULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Deborah D. Chin, Christopher Poon, Jonathan Wang, Johan Joo, Victor Ong, Zhangjingyi Jiang, Kayley Cheng, Anastasia Plotkin, Gregory A. Magee, Eun Ji Chung
Summary: The delivery of miR-145 micelles to VSMCs shows promise in mitigating atherosclerosis progression by altering cell phenotypes and reducing plaque growth. In mouse experiments, miR-145 micelles significantly inhibited the advancement of atherosclerosis.
Article
Medicine, Research & Experimental
Yarong Liu, Aiwei Song, Hongfei Wu, Yin Sun, Min Dai
Summary: Paeonol induces autophagy in VSMCs by activating the III class PI3K/Beclin-1 signaling pathway, ultimately inhibiting VSMCs apoptosis.
Article
Cardiac & Cardiovascular Systems
Jochen Dutzmann, Marco Haertle, Jan-Marcus Daniel, Frederik Kloss, Robert-Jonathan Musmann, Katrin Kalies, Kai Knopp, Claudia Pilowski, Mirja Sirisko, Jan-Thorben Sieweke, Johann Bauersachs, Daniel G. Sedding, Simona Gegel
Summary: Selective inhibition of BET proteins can reduce proliferation and migration of SMCs by regulating FOXO1 transcription factor, leading to cell cycle arrest and prevention of neointima formation. Inhibition of BET epigenetic reader proteins may represent a promising therapeutic strategy to prevent adverse vascular remodeling.
CARDIOVASCULAR RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ning Yang, Bo Dong, Yanqiu Song, Yang Li, Lu Kou, Qin Qin
Summary: This research investigated the role of CLU in regulating VSMC proliferation and migration in vascular restenosis. The findings showed that CLU was highly expressed in vascular restenosis and over-expression of CLU promoted VSMC autophagy, thus attenuating intimal hyperplasia and vascular restenosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Utsab Subedi, Shrivats Manikandan, Susmita Bhattarai, Papori Sharma, Sudha Sharma, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our study found that autotaxin (ATX) and lysophosphatidic acid (LPA) play a role in VSMC proliferation and migration during restenosis. Inhibition of the ATX-LPA axis could potentially be used as a therapeutic target to minimize VSMC phenotypic modulation and inflammation after vascular injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Karim J. Brandt, Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Kapka Miteva
Summary: The study revealed the crucial role of GDF10 in the phenotypic switch of VSMCs, which may have a detrimental impact on the stability of atherosclerotic plaques and increase the risk of carotid artery disease (CAD) events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Katherine M. Owsiany, Rebecca A. Deaton, Karen G. Soohoo, Anh Tram Nguyen, Gary K. Owens
Summary: This study investigates the contribution of MCP1 produced by classical smooth muscle cells (SMCs) and Lgals3-transitioned SMCs in atherosclerosis. The results show that MCP1 produced by classical SMCs has an atheroprotective effect, while MCP1 produced by Lgals3-transitioned SMCs exacerbates plaque pathogenesis. These findings highlight the need for caution when considering therapeutic interventions involving MCP1.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Paul Cheng, Robert C. Wirka, Lee Shoa Clarke, Quanyi Zhao, Ramendra Kundu, Trieu Nguyen, Surag Nair, Disha Sharma, Hyun-jung Kim, Huitong Shi, Themistocles Assimes, Juyong Brian Kim, Anshul Kundaje, Thomas Quertermous
Summary: This study identifies ZEB2 as a new CAD genome-wide association study gene that affects features of plaque vulnerability through direct effects on the epigenome, providing a new therapeutic approach to target vascular disease.
Article
Medicine, Research & Experimental
Andrei Maiseyeu, Lin Di, Anastasia Ravodina, Alma Barajas-Espinosa, Atsushi Sakamoto, Alice Chaplin, Jixin Zhong, Huiyun Gao, Matthew Mignery, Navneet Narula, Aloke Finn, Sanjay Rajagopalan
Summary: GLP-1R agonists have been shown to lower cardiovascular events and mortality, but their specific effects on atherosclerosis have been unclear. This study demonstrates that targeted agonists of GLP-1R may alleviate vascular inflammation and plaque burden in atherosclerosis, even at low doses. The engineered nanoparticles carrying GLP-1R agonist showed promising results in reducing atherosclerosis, cholesterol, and triglyceride-rich lipoproteins in Apoe(-/-) mice.
Article
Cardiac & Cardiovascular Systems
Floriana Maria Farina, Simone Serio, Ignacio Fernando Hall, Stefania Zani, Giada Andrea Cassanmagnago, Montserrat Climent, Efrem Civilini, Gianluigi Condorelli, Manuela Quintavalle, Leonardo Elia
Summary: DOT1L inhibition in VSMCs significantly reduces atherosclerosis progression by directly modulating Nf-kappa B1 and Nf-kappa B2 transcription, which are master regulators of inflammation inducing expression of CCL5 and CXCL10 cytokines, key in atherosclerosis development. DOT1L could be a promising therapeutic target for vascular diseases as its inhibition reduces plaque progression.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Meili Wang, Shuanglei Li, Hongshan Liu, Mingyuan Liu, Jin Zhang, Yang Wu, Cangsong Xiao, Haixia Huang
Summary: The expression of BK(Ca)-beta 1 plays a crucial role in maintaining the contractile phenotype of VSMCs, preventing pathological phenotype switching. It may serve as a potential therapeutic target for treating vascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Amy Pei-Ling Chiu, Andrea Wan, Nathaniel Lal, Dahai Zhang, Fulong Wang, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Amy Pei-Ling Chiu, Andrea Wan, Brian Rodrigues
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2016)
Article
Endocrinology & Metabolism
Dahai Zhang, Fulong Wang, Nathaniel Lal, Amy Pei-Ling Chiu, Andrea Wan, Jocelyn Jia, Denise Bierende, Stephane Flibotte, Sunita Sinha, Ali Asadi, Xiaoke Hu, Farnaz Taghizadeh, Thomas Pulinilkunnil, Corey Nislow, Israel Vlodavsky, James D. Johnson, Timothy J. Kieffer, Bahira Hussein, Brian Rodrigues
Article
Cardiac & Cardiovascular Systems
Amy Pei-Ling Chiu, Denise Bierende, Nathaniel Lal, Fulong Wang, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Melissa M. Page, Sos Skovso, Haoning Cen, Amy P. Chiu, Derek A. Dionne, Daria F. Hutchinson, Gareth E. Lim, Marta Szabat, Stephane Flibotte, Sunita Sinha, Corey Nislow, Brian Rodrigues, James D. Johnson
Article
Biochemistry & Molecular Biology
Han Yingchun, Ma Yahong, Wen Jiangping, He Xiaokui, Zhang Xiaohong
LIPIDS IN HEALTH AND DISEASE
(2018)
Article
Cardiac & Cardiovascular Systems
Fulong Wang, Thomas Pulinilkunnil, Stephane Flibotte, Corey Nislow, Israel Vlodaysky, Bahira Hussein, Brian Rodrigues
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Yang Li, Han Yan, Jian Guo, Yingchun Han, Cuifang Zhang, Xiuying Liu, Jie Du, Xiao-Li Tian
Summary: This study identified RGS5 as a novel susceptibility gene for CAD through integrative analysis of transcriptome profiles with genome-wide association studies. Decreased expression of RGS5 was shown to impair endothelial cell function and functionally contribute to atherosclerosis through various molecular mechanisms. Further studies are needed to elucidate how RGS5 regulates the expression of CXCL12.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Karanjit Puri, Nathaniel Lal, Rui Shang, Sanjoy Ghosh, Stephane Flibotte, Roger Dyer, Bahira Hussein, Brian Rodrigues
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Biochemistry & Molecular Biology
Naixuan Cheng, Chang Liu, Yulin Li, Shijuan Gao, Ying-Chun Han, Xiaonan Wang, Jie Du, Congcong Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Cardiac & Cardiovascular Systems
Yang Li, Shijuan Gao, Yingchun Han, Li Song, Yu Kong, Yao Jiao, Shan Huang, Jie Du, Yulin Li
Summary: This study investigated the genetic characteristics of sporadic isolated thoracic aortic aneurysm (iTAA) and revealed the potential role of focal adhesion scaffold genes in the pathogenesis of iTAA. Pathogenic mutations and suspected functional variants were found to be significantly enriched in iTAA patients, with Testin (TES) identified as a potential causal gene. The study also showed that knockdown of focal adhesion scaffold genes like TLN1 and ZYX resulted in decreased contractility of vascular smooth muscle cells in iTAA patients.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yingchun Han, Jichao Zhang, Shan Huang, Naixuan Cheng, Congcong Zhang, Yulin Li, Xiaonan Wang, Jinghua Liu, Bin You, Jie Du
Summary: The study identified miR-223-3p as a protective factor in vascular calcification by regulating IL-6/STAT3 signaling to inhibit VSMC osteogenic differentiation, thereby preventing both medial and atherosclerotic vascular calcification.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Cardiac & Cardiovascular Systems
Fulong Wang, Jocelyn Jia, Brian Rodrigues
CANADIAN JOURNAL OF CARDIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Nathaniel Lal, Amy Pei-Ling Chiu, Fulong Wang, Dahai Zhang, Jocelyn Jia, Andrea Wan, Israel Vlodavsky, Bahira Hussein, Brian Rodrigues
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2017)
Review
Pharmacology & Pharmacy
Yi-ni Cao, Lu Xu, Ying-chun Han, Yu-nan Wang, George Liu, Rong Qi
DRUG DISCOVERY TODAY
(2017)