Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cells

(2019) Marion Gabel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow

(2019) Bochuan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

(2019) Seema Irani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex

(2019) Yongtai Bai et al.   MOLECULAR CELL

Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis

(2019) Sanguk Yun et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular dissection of the membrane aggregation mechanisms induced by monomeric annexin A2

(2018) Juan C. López-Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial CellsNovelty and Significance

(2018) Jinlong He et al.   CIRCULATION RESEARCH

Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

(2018) Tuoyi Li et al.   Nature Communications

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding

(2017) Péter Ecsédi et al.   STRUCTURE

Myeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE −/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway

(2017) D. Thompson et al.   Molecular Metabolism

Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release

(2016) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling

(2016) Sanguk Yun et al.   NATURE CELL BIOLOGY

Activation of integrin α5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells

(2016) Xiaoli Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dual structural roles of the membrane distal region of the  -integrin cytoplasmic tail during integrin inside-out activation

(2015) J. Liu et al.   JOURNAL OF CELL SCIENCE

Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

(2014) Petrus R. de Jong et al.   JOURNAL OF CLINICAL INVESTIGATION

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Activation of Rab8 guanine nucleotide exchange factor Rabin8 by ERK1/2 in response to EGF signaling

(2014) Juanfei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Annexin A2 Heterotetramer: Structure and Function

(2013) Alamelu Bharadwaj et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mena binds α5 integrin directly and modulates α5β1 function

(2012) Stephanie L. Gupton et al.   JOURNAL OF CELL BIOLOGY

Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia

(2012) J A P Spijkers-Hagelstein et al.   LEUKEMIA

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

(2012) Nabil G. Seidah et al.   PLoS One

Interferon-γ stimulates p11-dependent surface expression of annexin A2 in lung epithelial cells to enhance phagocytosis

(2011) Yi-Ting Fang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Tyrosine 23 Phosphorylation-Dependent Cell-Surface Localization of Annexin A2 Is Required for Invasion and Metastases of Pancreatic Cancer

(2011) Lei Zheng et al.   PLoS One

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion

(2008) U. Rescher et al.   JOURNAL OF CELL SCIENCE

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY