标题
The complex role of SIRT6 in carcinogenesis
作者
关键词
-
出版物
CARCINOGENESIS
Volume 37, Issue 2, Pages 108-118
出版商
Oxford University Press (OUP)
发表日期
2016-01-12
DOI
10.1093/carcin/bgv167
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Sirtuins at the Breaking Point: SIRT6 in DNA Repair
- (2016) David B. Lombard Aging-US
- SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair
- (2016) Ronald A. McCord et al. Aging-US
- Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence
- (2015) Xin-Xia Feng et al. CANCER SCIENCE
- APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells
- (2015) A. Cagnetta et al. CLINICAL CANCER RESEARCH
- Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics
- (2015) Giovanna Sociali et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Putative tumor suppression function of SIRT6 in endometrial cancer
- (2015) Tomohiko Fukuda et al. FEBS LETTERS
- Cyclic AMP Signaling Reduces Sirtuin 6 Expression in Non-small Cell Lung Cancer Cells by Promoting Ubiquitin-Proteasomal Degradation via Inhibition of the Raf-MEK-ERK (Raf/Mitogen-activated Extracellular Signal-regulated Kinase/Extracellular Signal-regulated Kinase) Pathway
- (2015) Eui-Jun Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells
- (2015) Moran Choe et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer
- (2015) Yoko Azuma et al. JOURNAL OF SURGICAL ONCOLOGY
- Expression of SIRT2 and SIRT6 in Retinoblastoma
- (2015) Maria Eugenia Orellana et al. OPHTHALMIC RESEARCH
- Balancing the innate immune system in tumor development
- (2015) Catharina Hagerling et al. TRENDS IN CELL BIOLOGY
- SIRT3 regulates progression and development of diseases of aging
- (2015) Eoin McDonnell et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells
- (2015) Minghui Wu et al. Oncotarget
- ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice
- (2015) R. Stöhr et al. Scientific Reports
- Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer
- (2015) Sita Kugel et al. Cell Reports
- The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and Disease
- (2015) Jean-Pierre Etchegaray et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Radiosensitization Effect of Overexpression of Adenovirus-mediated SIRT6 on A549 Non-small Cell Lung Cancer Cells
- (2014) Yong Cai et al. Asian Pacific Journal of Cancer Prevention
- The histone acetyltransferase hMOF suppresses hepatocellular carcinoma growth
- (2014) Jin Zhang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The histone deacetylase SIRT6 suppresses the expression of the RNA-binding protein PCBP2 in glioma
- (2014) Xin Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer
- (2014) M. Ming et al. CANCER RESEARCH
- Blocking Lipid Synthesis Overcomes Tumor Regrowth and Metastasis after Antiangiogenic Therapy Withdrawal
- (2014) Nor Eddine Sounni et al. Cell Metabolism
- The Promoter Methylation Status and mRNA Expression Levels of CTCF and SIRT6 in Sporadic Breast Cancer
- (2014) Da Wang et al. DNA AND CELL BIOLOGY
- Twist-1 Up-Regulation in Carcinoma Correlates to Poor Survival
- (2014) Alimujiang Wushou et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Discovery of Novel and Selective SIRT6 Inhibitors
- (2014) Marco Daniele Parenti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion
- (2014) P. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
- (2014) U. Thirumurthi et al. Science Signaling
- SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
- (2014) Michael Van Meter et al. Nature Communications
- What are the roles of calorie restriction and diet quality in promoting healthy longevity?
- (2013) Wanda Rizza et al. AGEING RESEARCH REVIEWS
- SIRT6, a protein with many faces
- (2013) Asaf A. Gertler et al. BIOGERONTOLOGY
- SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer
- (2013) Mattaka Khongkow et al. CARCINOGENESIS
- A miR-34a-SIRT6 axis in the squamous cell differentiation network
- (2013) Karine Lefort et al. EMBO JOURNAL
- Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients
- (2013) Jens U. Marquardt et al. HEPATOLOGY
- The Role of SIRT6 Protein in Aging and Reprogramming of Human Induced Pluripotent Stem Cells
- (2013) Amit Sharma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
- (2013) Jessica L. Feldman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination
- (2013) Sarah M. Ronnebaum et al. MOLECULAR AND CELLULAR BIOLOGY
- SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability through Chromatin Remodeling
- (2013) Debra Toiber et al. MOLECULAR CELL
- SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
- (2013) Hong Jiang et al. NATURE
- SIRT6 exhibits nucleosome-dependent deacetylase activity
- (2013) R. Gil et al. NUCLEIC ACIDS RESEARCH
- Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling
- (2013) Jinying Piao et al. Scientific Reports
- USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation
- (2013) Zhenghong Lin et al. Cell Reports
- Multiple Regulatory Layers of SREBP1/2 by SIRT6
- (2013) Sivan Elhanati et al. Cell Reports
- Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics
- (2013) Yewei Liu et al. Protein & Cell
- SIRT1 metabolic actions: Integrating recent advances from mouse models
- (2013) Marie Boutant et al. Molecular Metabolism
- The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
- (2012) Carlos Sebastián et al. CELL
- Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets
- (2012) Santina Bruzzone et al. CURRENT PHARMACEUTICAL DESIGN
- The guardian: metabolic and tumour-suppressive effects of SIRT6
- (2012) Batya Lerrer et al. EMBO JOURNAL
- The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+Responses
- (2012) Inga Bauer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Deacetylase Sirt6 Activates the Acetyltransferase GCN5 and Suppresses Hepatic Gluconeogenesis
- (2012) John E. Dominy et al. MOLECULAR CELL
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
- (2012) Lihua Min et al. NATURE CELL BIOLOGY
- Sirtuins as regulators of metabolism and healthspan
- (2012) Riekelt H. Houtkooper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Histone Deacetylase in Chronic Lymphocytic Leukemia
- (2012) J.C. Wang et al. ONCOLOGY
- Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors
- (2012) Piia Kokkonen et al. ACS Medicinal Chemistry Letters
- Small-Molecule Allosteric Activators of Sirtuins
- (2011) David A. Sinclair et al. Annual Review of Pharmacology and Toxicology
- SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
- (2011) Lydia W.S. Finley et al. CANCER CELL
- IL-8 Signaling Plays a Critical Role in the Epithelial-Mesenchymal Transition of Human Carcinoma Cells
- (2011) R. I. Fernando et al. CANCER RESEARCH
- Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6
- (2011) Eriko Michishita et al. CELL CYCLE
- The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
- (2011) Bo Yang et al. CELL CYCLE
- SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
- (2011) Michael Van Meter et al. CELL CYCLE
- Structure and Biochemical Functions of SIRT6
- (2011) Patricia W. Pan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuins: Molecular Traffic Lights in the Crossroad of Oxidative Stress, Chromatin Remodeling, and Transcription
- (2011) Ramkumar Rajendran et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome
- (2011) Matthew D. Hirschey et al. MOLECULAR CELL
- Activation of Peroxisome Proliferator-Activated Receptor Gamma by Rosiglitazone Increases Sirt6 Expression and Ameliorates Hepatic Steatosis in Rats
- (2011) Soo Jin Yang et al. PLoS One
- SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
- (2011) Z. Mao et al. SCIENCE
- Mammalian Sirtuins: Biological Insights and Disease Relevance
- (2010) Marcia C. Haigis et al. Annual Review of Pathology-Mechanisms of Disease
- SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress
- (2010) Hyun-Seok Kim et al. CANCER CELL
- Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma
- (2010) Sang G. Jung et al. CANCER SCIENCE
- USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
- (2010) Jian Yuan et al. CELL
- The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
- (2010) Lei Zhong et al. CELL
- Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
- (2010) Hyun-Seok Kim et al. Cell Metabolism
- Obesity and Cancer
- (2010) K. Y. Wolin et al. ONCOLOGIST
- Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
- (2010) Abderrahmane Kaidi et al. SCIENCE
- SIRT6 protects against pathological damage caused by diet-induced obesity
- (2009) Yariv Kanfi et al. AGING CELL
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
- (2009) Tiara L.A. Kawahara et al. CELL
- CBP/p300-mediated acetylation of histone H3 on lysine 56
- (2009) Chandrima Das et al. NATURE
- Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner
- (2009) Frédéric Van Gool et al. NATURE MEDICINE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Regulation of SIRT1 protein levels by nutrient availability
- (2008) Yariv Kanfi et al. FEBS LETTERS
- Regulation of SIRT6 protein levels by nutrient availability
- (2008) Yariv Kanfi et al. FEBS LETTERS
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
- (2008) Eriko Michishita et al. NATURE
- Estimating the number of U.S. incident cancers attributable to obesity and the impact on temporal trends in incidence rates for obesity-related cancers
- (2008) Anthony P. Polednak Cancer Detection and Prevention
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More