MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
出版年份 2014 全文链接
标题
MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
作者
关键词
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出版物
Science Signaling
Volume 7, Issue 336, Pages ra71-ra71
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2014-07-30
DOI
10.1126/scisignal.2005076
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair
- (2016) Ronald A. McCord et al. Aging-US
- A Proteomic Perspective of Sirtuin 6 (SIRT6) Phosphorylation and Interactions and Their Dependence on Its Catalytic Activity
- (2013) Yana V. Miteva et al. MOLECULAR & CELLULAR PROTEOMICS
- The Ubiquitin Ligase CHIP Prevents SirT6 Degradation through Noncanonical Ubiquitination
- (2013) Sarah M. Ronnebaum et al. MOLECULAR AND CELLULAR BIOLOGY
- Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability
- (2013) Kirsten Achilles Poon et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation
- (2013) Zhenghong Lin et al. Cell Reports
- Increased signalling of EGFR and IGF1R and deregulation of PTEN/PI3K/Akt pathway are related with trastuzumab resistance in HER2 breast carcinomas
- (2012) A Gallardo et al. BRITISH JOURNAL OF CANCER
- The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis
- (2012) Chia-Hsin Chan et al. CELL
- The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
- (2012) Carlos Sebastián et al. CELL
- Frequent Mutational Activation of the PI3K-AKT Pathway in Trastuzumab-Resistant Breast Cancer
- (2012) S. Chandarlapaty et al. CLINICAL CANCER RESEARCH
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin
- (2012) Lihua Min et al. NATURE CELL BIOLOGY
- The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
- (2012) Nagalingam R Sundaresan et al. NATURE MEDICINE
- Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6
- (2011) Eriko Michishita et al. CELL CYCLE
- The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability
- (2011) Bo Yang et al. CELL CYCLE
- Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
- (2011) Siyuan Zhang et al. NATURE MEDICINE
- SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
- (2011) Z. Mao et al. SCIENCE
- Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans
- (2011) J. Guevara-Aguirre et al. Science Translational Medicine
- SIRT6 is required for maintenance of telomere position effect in human cells
- (2011) Ruth I. Tennen et al. Nature Communications
- USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
- (2010) Jian Yuan et al. CELL
- The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
- (2010) Lei Zhong et al. CELL
- Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
- (2010) Hyun-Seok Kim et al. Cell Metabolism
- Evolving Strategies for Overcoming Resistance to HER2-Directed Therapy: Targeting the PI3K/Akt/mTOR Pathway
- (2010) Rita Nahta et al. Clinical Breast Cancer
- SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice
- (2010) Cuiying Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
- (2010) Abderrahmane Kaidi et al. SCIENCE
- Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
- (2009) Teemu T. Junttila et al. CANCER CELL
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
- (2009) Tiara L.A. Kawahara et al. CELL
- Recent progress in the biology and physiology of sirtuins
- (2009) Toren Finkel et al. NATURE
- Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer
- (2008) Weiya Xia et al. MOLECULAR CARCINOGENESIS
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
- (2008) Eriko Michishita et al. NATURE
- Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling
- (2008) Qing-Bai She et al. PLoS One
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