RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

NEDD8 nucleates a multivalent cullin–RING–UBE2D ubiquitin ligation assembly

(2020) Kheewoong Baek et al.   NATURE

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

(2020) Annette M. Vogl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS

(2020) Richard M Hooy et al.   NUCLEIC ACIDS RESEARCH

Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling

(2019) Ramya Nandakumar et al.   Nature Microbiology

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

(2019) Xiang Gui et al.   NATURE

Unanchored tri‐NEDD8 inhibits PARP‐1 to protect from oxidative stress‐induced cell death

(2019) Matthew J Keuss et al.   EMBO JOURNAL

Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity

(2019) Jiang Dai et al.   CELL

Neddylation: a novel modulator of the tumor microenvironment

(2019) Lisha Zhou et al.   Molecular Cancer

PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer

(2019) Constantia Pantelidou et al.   Cancer Discovery

Promotion of tumor-associated macrophages infiltration by elevated neddylation pathway via NF-κB-CCL2 signaling in lung cancer

(2019) Lisha Zhou et al.   ONCOGENE

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

(2019) Ki Wung Chung et al.   Cell Metabolism

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

(2019) Annie M. Sriramachandran et al.   Nature Communications

The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

(2019) Aymeric P. Bailly et al.   Cell Reports

Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

(2018) Chenguang Wang et al.   IMMUNITY

Rapid remodeling of the host epithelial cell proteome by the listeriolysin O pore-forming toxin

(2018) Julien Karim Malet et al.   MOLECULAR & CELLULAR PROTEOMICS

The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168

(2018) Xiaoduo Xie et al.   NATURE CELL BIOLOGY

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing

(2018) Gil Ju Seo et al.   Nature Communications

G3BP1 promotes DNA binding and activation of cGAS

(2018) Zhao-Shan Liu et al.   NATURE IMMUNOLOGY

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

(2018) Sulayman Benmerzoug et al.   Nature Communications

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

(2018) Lele Zhang et al.   PLoS Pathogens

SAG/RBX2 E3 Ubiquitin Ligase Differentially Regulates Inflammatory Responses of Myeloid Cell Subsets

(2018) Xiufang Xiong et al.   Frontiers in Immunology

A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity

(2017) Maria Birkou et al.   JOURNAL OF MOLECULAR BIOLOGY

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

IRF3 and type I interferons fuel a fatal response to myocardial infarction

(2017) Kevin R King et al.   NATURE MEDICINE

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

(2017) Ye Cui et al.   PLoS Pathogens

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function

(2017) Shan He et al.   Scientific Reports

The MLN4924 inhibitor exerts a neuroprotective effect against oxidative stress injury via Nrf2 protein accumulation

(2016) Ana Cristina Andérica-Romero et al.   Redox Biology

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Neddylation is required for herpes simplex virus type I (HSV-1)-induced early phase interferon-beta production

(2015) Xueying Zhang et al.   Cellular & Molecular Immunology

Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responses

(2015) Valerie F. Curtis et al.   FASEB JOURNAL

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neddylation inhibits CtIP-mediated resection and regulates DNA double strand break repair pathway choice

(2015) Sonia Jimeno et al.   NUCLEIC ACIDS RESEARCH

The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma

(2015) A Mizutani et al.   ONCOGENE

Ubiquitylation, neddylation and the DNA damage response

(2015) J. S. Brown et al.   Open Biology

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

The Bacterial Fermentation Product Butyrate Influences Epithelial Signaling via Reactive Oxygen Species-Mediated Changes in Cullin-1 Neddylation

(2014) A. Kumar et al.   JOURNAL OF IMMUNOLOGY

Nedd8 Regulates Inflammasome-Dependent Caspase-1 Activation

(2014) Jesus A. Segovia et al.   MOLECULAR AND CELLULAR BIOLOGY

The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis

(2014) Ping Xie et al.   Nature Communications

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

Neddylation plays an important role in the regulation of murine and human dendritic cell function

(2013) N. Mathewson et al.   BLOOD

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

(2013) Sara L. Poulsen et al.   JOURNAL OF CELL BIOLOGY

Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation

(2013) Y. Erker et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

(2013) Wei Zuo et al.   MOLECULAR CELL

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

(2013) Teng Ma et al.   MOLECULAR CELL

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Neddylation pathway regulates T-cell function by targeting an adaptor protein Shc and a protein kinase Erk signaling

(2012) H.-s. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of TGF-  Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

(2011) V. Sharma et al.   CANCER RESEARCH

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

(2009) Danny T. Huang et al.   MOLECULAR CELL

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

(2009) Teresa A. Soucy et al.   NATURE

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

(2008) Thimo Kurz et al.   MOLECULAR CELL