The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

RNase H2 catalytic core Aicardi-Goutières syndrome–related mutant invokes cGAS–STING innate immune-sensing pathway in mice

(2016) Vladislav Pokatayev et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Erratum: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

ReGLUation of cGAS

(2016) Andrea Ablasser   NATURE IMMUNOLOGY

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

(2016) Wei Chen et al.   PLoS Pathogens

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

(2015) Ruth Wassermann et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

(2015) Jian-jun Wu et al.   Cell Host & Microbe

Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum

(2015) Qiang Wang et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

The emerging roles of the STING adaptor protein in immunity and diseases

(2015) Xing Liu et al.   IMMUNOLOGY

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

(2015) Gil Ju Seo et al.   Cell Reports

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

The E3 ligase RNF185 negatively regulates osteogenic differentiation by targeting Dvl2 for degradation

(2014) Ying Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

(2014) Michael J. White et al.   CELL

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease

(2014) Jeonghyun Ahn et al.   CURRENT OPINION IN IMMUNOLOGY

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

(2013) Xing Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

(2013) Xin Li et al.   IMMUNITY

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

RNF185 Is a Novel E3 Ligase of Endoplasmic Reticulum-associated Degradation (ERAD) That Targets Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2013) Elma El Khouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural mechanism of cytosolic DNA sensing by cGAS

(2013) Filiz Civril et al.   NATURE

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

(2013) X.-D. Li et al.   SCIENCE

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

(2013) Philip J. Kranzusch et al.   Cell Reports

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

RNF185, a Novel Mitochondrial Ubiquitin E3 Ligase, Regulates Autophagy through Interaction with BNIP1

(2011) Fei Tang et al.   PLoS One

Innate Immune Sensing of DNA

(2011) Shruti Sharma et al.   PLoS Pathogens

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

Negative Feedback Regulation of NF- B Action by CITED2 in the Nucleus

(2010) X. Lou et al.   JOURNAL OF IMMUNOLOGY

Positive Regulation of Interferon Regulatory Factor 3 Activation by Herc5 via ISG15 Modification

(2010) H. X. Shi et al.   MOLECULAR AND CELLULAR BIOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF- B activation

(2009) Y.-Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-I-like receptors: Sensing and responding to RNA virus infection

(2009) Peyman Nakhaei et al.   SEMINARS IN IMMUNOLOGY

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE