Toll-like receptors and metabolic (dysfunction)-associated fatty liver disease

Heat Shock Protein 60 Restricts Release of Mitochondrial dsRNA to Suppress Hepatic Inflammation and Ameliorate Non-Alcoholic Fatty Liver Disease in Mice

(2022) Ying-Hsien Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice

(2022) Eleonora Cremonini et al.   Food & Function

Prevalence and Risk Factors of Metabolic-Associated Fatty Liver Disease among 73,566 Individuals in Beijing, China

(2022) Qianli Yuan et al.   International Journal of Environmental Research and Public Health

Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway

(2022) Bin Jiang et al.   Molecular Metabolism

Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on ongoing hepatic fibrosis

(2022) Tadashi Namisaki et al.   Indian Journal of Gastroenterology

Corydalis saxicola Bunting Total Alkaloids ameliorate diet-induced non-alcoholic steatohepatitis by regulating hepatic PI3K/Akt and TLR4/NF-κB pathways in mice

(2022) Jiejie Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Obeticholic acid orchestrates the crosstalk between ileal autophagy and tight junctions in non-alcoholic steatohepatitis: Role of TLR4/TGF-β1 axis

(2022) Rasha A. Tawfiq et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Marine Chitooligosaccharide Alters Intestinal Flora Structure and Regulates Hepatic Inflammatory Response to Influence Nonalcoholic Fatty Liver Disease

(2022) Jiayao Feng et al.   Marine Drugs

Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway

(2022) Si-Ran Yue et al.   Frontiers in Endocrinology

Role of Toll‐like receptors in the pathogenesis of COVID‐19

(2021) Shaghayegh Khanmohammadi et al.   JOURNAL OF MEDICAL VIROLOGY

Astragaloside IV Improves High-Fat Diet–Induced Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Rats by Regulating Inflammatory Factors Level via TLR4/NF-κB Signaling Pathway

(2021) Ying-Li Liu et al.   Frontiers in Pharmacology

Toll‐like receptor 5 and 8 in hepatocellular carcinoma

(2021) Valtteri Kairaluoma et al.   APMIS

Dulaglutide Alone and in Combination with Empagliflozin Attenuate Inflammatory Pathways and Microbiome Dysbiosis in a Non-Diabetic Mouse Model of NASH

(2021) Katharina Luise Hupa-Breier et al.   Biomedicines

SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury

(2021) Anteneh Getachew et al.   iScience

Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis

(2021) Shogo Kawaguchi et al.   INFLAMMATION

Toll-like receptor 3 ablation prevented high-fat diet-induced obesity and metabolic disorder

(2021) Guoqing Zhang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Comprehensive analysis of LncRNAs expression profiles in an in vitro model of steatosis treated with Exendin-4

(2021) Khaoula Errafii et al.   Journal of Translational Medicine

Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses

(2021) Yujuan Chen et al.   Journal of Zhejiang University-SCIENCE B

A genetic variant in toll‐like receptor 5 is linked to chemokine levels and hepatocellular carcinoma in steatohepatitis

(2021) Hans Dieter Nischalke et al.   LIVER INTERNATIONAL

Attenuating Effects of Dieckol on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Decreasing the NLRP3 Inflammasome and Pyroptosis

(2021) Seyeon Oh et al.   Marine Drugs

Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway

(2021) Nancy S. Younis et al.   Scientific Reports

Toll-like receptor 1 as a possible target in non-alcoholic fatty liver disease

(2021) Anja Baumann et al.   Scientific Reports

Hepatic protective effects of Shenling Baizhu powder, a herbal compound, against inflammatory damage via TLR4/NLRP3 signalling pathway in rats with nonalcoholic fatty liver disease

(2021) Mao-xing Pan et al.   Journal of Integrative Medicine-JIM

LncRNA TLR8-AS1 suppresses miR-34a maturation in hepatocellular carcinoma to suppress cell proliferation and migration

(2021) Xin Shi et al.   MAMMALIAN GENOME

Metabolic-Associated Fatty Liver Disease (MAFLD), Diabetes, and Cardiovascular Disease: Associations with Fructose Metabolism and Gut Microbiota

(2021) Karolina Drożdż et al.   Nutrients

The Effects of Pathogen-Associated Molecular Patterns on Peripheral Blood Monocytes in Patients with Non-alcoholic Fatty Liver Disease

(2021) Qian Li et al.   Journal of Clinical and Experimental Hepatology

Toll-Like Receptor 5 Signaling Ameliorates Liver Fibrosis by Inducing Interferon β–Modulated IL-1 Receptor Antagonist in Mice

(2020) Zixiong Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Baicalin and its nanoliposomes ameliorates nonalcoholic fatty liver disease via suppression of TLR4 signaling cascade in mice

(2020) Jin Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulation of lipid‐induced macrophage polarization through modulating PPAR‐γ activity affects hepatic lipid metabolism via TLR4/NF‐κB signaling pathway

(2020) Hui‐Min Wu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Direct inhibition of TLR4/MyD88 pathway by geniposide suppresses HIF1α‐independent VEGF expression and hepatocellular carcinoma angiogenesis

(2020) Cheng Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial DNA from hepatocytes induces upregulation of interleukin-33 expression of macrophages in nonalcoholic steatohepatitis

(2020) Yinjie Gao et al.   DIGESTIVE AND LIVER DISEASE

TLR3 promotes hepatocyte proliferation after partial hepatectomy by stimulating uPA expression and the release of tissue‐bound HGF

(2020) Christian Stöß et al.   FASEB JOURNAL

Exenatide ameliorates experimental non-alcoholic fatty liver in rats via suppression of toll-like receptor 4/NFκB signaling: Comparison to metformin

(2020) Zeinab A. Saad et al.   LIFE SCIENCES

Inulin Exerts Beneficial Effects on Non-Alcoholic Fatty Liver Disease via Modulating gut Microbiome and Suppressing the Lipopolysaccharide-Toll-Like Receptor 4-Mψ-Nuclear Factor-κB-Nod-Like Receptor Protein 3 Pathway via gut-Liver Axis in Mice

(2020) Ting Bao et al.   Frontiers in Pharmacology

Small Bowel Resection Increases Paracellular Gut Barrier Permeability via Alterations of Tight Junction Complexes Mediated by Intestinal TLR4

(2020) Cathleen M. Courtney et al.   JOURNAL OF SURGICAL RESEARCH

Saroglitazar Deactivates the Hepatic LPS/TLR4 Signaling Pathway and Ameliorates Adipocyte Dysfunction in Rats with High-Fat Emulsion/LPS Model-Induced Non-alcoholic Steatohepatitis

(2019) Noha F. Hassan et al.   INFLAMMATION

Dieckol or phlorofucofuroeckol extracted from Ecklonia cava suppresses lipopolysaccharide-mediated human breast cancer cell migration and invasion

(2019) Young-Ju Lee et al.   JOURNAL OF APPLIED PHYCOLOGY

Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice

(2019) Beibei Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Toll-Like Receptor-7 Signaling Promotes Nonalcoholic Steatohepatitis by Inhibiting Regulatory T Cells in Mice

(2018) Yoon Seok Roh et al.   AMERICAN JOURNAL OF PATHOLOGY

Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation

(2017) David Porras et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transmembrane BAX Inhibitor motif-containing 1, a novel anti-inflammatory approach for nonalcoholic steatohepatitis treatment

(2017) Alexander Wree et al.   HEPATOLOGY

Hypoxia mediates mitochondrial biogenesis in hepatocellular carcinoma to promote tumor growth through HMGB1 and TLR9 interaction

(2017) Samer Tohme et al.   HEPATOLOGY

Toll-like receptor 4 is critical for the development of resection-associated hepatic steatosis

(2017) Lauren K. Barron et al.   JOURNAL OF PEDIATRIC SURGERY

Toll like receptor 4 and hepatocellular carcinoma; A systematic review

(2017) Zahra Sepehri et al.   LIFE SCIENCES

Tmbim1 is a multivesicular body regulator that protects against non-alcoholic fatty liver disease in mice and monkeys by targeting the lysosomal degradation of Tlr4

(2017) Guang-Nian Zhao et al.   NATURE MEDICINE

Inhibition of MAPK and NF-κB signaling pathways alleviate carbon tetrachloride (CCl4)-induced liver fibrosis in Toll-like receptor 5 (TLR5) deficiency mice

(2016) Ming Shu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models

(2016) Mitsuaki Ishioka et al.   DIGESTIVE DISEASES AND SCIENCES

Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis

(2016) Wonhyo Seo et al.   HEPATOLOGY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR4-dependent signaling pathway modulation: A novel mechanism by which pioglitazone protects against nutritional fibrotic steatohepatitis in mice

(2016) JINGHUA DU et al.   Molecular Medicine Reports

TLR7 agonist induced repression of hepatocellular carcinoma via the TLR7-IKK-NF-κB-IL6 signaling pathway

(2016) XINGBIN REN et al.   Oncology Letters

Lipid rafts promote liver cancer cell proliferation and migration by up-regulation of TLR7 expression

(2016) Yuan Liu et al.   Oncotarget

Toll-like receptor 7 affects the pathogenesis of non-alcoholic fatty liver disease

(2016) Sokho Kim et al.   Scientific Reports

Isolated exopolysaccharides from Lactobacillus rhamnosus GG alleviated adipogenesis mediated by TLR2 in mice

(2016) Zhen Zhang et al.   Scientific Reports

TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis

(2015) Ming-Ming Yuan et al.   BMC CANCER

TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression

(2015) S. Li et al.   CANCER RESEARCH

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

Role of serum toll-like receptors 2 and 4 in non-alcoholic steatohepatitis and liver fibrosis

(2015) Mustafa Cengiz et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Berberine Prevents Intestinal Mucosal Barrier Damage During Early Phase of Sepsis in Rat through the Toll-Like Receptors Signaling Pathway

(2015) Guo-xun Li et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

(2015) Victor Ho et al.   Oncotarget

TLR4 signaling promotes a COX-2/PGE2/STAT3 positive feedback loop in hepatocellular carcinoma (HCC) cells

(2015) Ang Lin et al.   OncoImmunology

Toll like receptor 2 knock-out attenuates carbon tetrachloride (CCl4)-induced liver fibrosis by downregulating MAPK and NF-κB signaling pathways

(2014) Lingling Ji et al.   FEBS LETTERS

Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice

(2014) Benoit Chassaing et al.   GASTROENTEROLOGY

Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma

(2014) Fatma E. Mohamed et al.   LIVER INTERNATIONAL

Recognition of LPS by TLR4: Potential for Anti-Inflammatory Therapies

(2014) Reindert Nijland et al.   Marine Drugs

Suppression of toll-like receptor 2 expression inhibits the bioactivity of human hepatocellular carcinoma

(2014) Wenna Shi et al.   TUMOR BIOLOGY

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

(2014) Kouichi Miura   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics

(2014) Sander de Kivit et al.   Frontiers in Immunology

Betaine Protects Against High-Fat-Diet-Induced Liver Injury by Inhibition of High-Mobility Group Box 1 and Toll-Like Receptor 4 Expression in Rats

(2013) Wei Zhang et al.   DIGESTIVE DISEASES AND SCIENCES

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Toll-like receptor 7-mediated type I interferon signaling prevents cholestasis- and hepatotoxin-induced liver fibrosis

(2013) Yoon Seok Roh et al.   HEPATOLOGY

Toll-like receptors 3, 4 and 9 in hepatocellular carcinoma: Relationship with clinicopathological characteristics and prognosis

(2013) Noemí Eiró et al.   HEPATOLOGY RESEARCH

Hepatic stellate cells in liver development, regeneration, and cancer

(2013) Chunyue Yin et al.   JOURNAL OF CLINICAL INVESTIGATION

Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis

(2013) Yusaku Shirai et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Expression of toll-like receptors 1-5 but not TLR 6-10 is elevated in livers of patients with non-alcoholic fatty liver disease

(2013) Giridhar Kanuri et al.   LIVER INTERNATIONAL

Antioxidant N-Acetylcysteine Attenuates Hepatocarcinogenesis by Inhibiting ROS/ER Stress in TLR2 Deficient Mouse

(2013) Heng Lin et al.   PLoS One

Natural Killer Cell-Dependent Anti-Fibrotic Pathway in Liver Injury via Toll-Like Receptor-9

(2013) Lina Abu-Tair et al.   PLoS One

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: Modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression

(2012) Chuan-tao Tu et al.   FOOD AND CHEMICAL TOXICOLOGY

Toll-Like Receptor 2–Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice

(2012) Phillipp Hartmann et al.   GASTROENTEROLOGY

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

(2012) Kouichi Miura et al.   HEPATOLOGY

Loss of immunity-supported senescence enhances susceptibility to hepatocellular carcinogenesis and progression in Toll-like receptor 2-deficient mice

(2012) Heng Lin et al.   HEPATOLOGY

Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice

(2012) Linda H. Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway

(2012) Haitao Shi et al.   TOXICOLOGY

Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

(2011) Timea Csak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Toll-like receptors 1–9 are elevated in livers with fructose-induced hepatic steatosis

(2011) Sabine Wagnerberger et al.   BRITISH JOURNAL OF NUTRITION

Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells

(2011) Peng Shen et al.   CELL BIOLOGY INTERNATIONAL

Toll-like receptor signaling in liver regeneration, fibrosis and carcinogenesis

(2011) Ekihiro Seki et al.   HEPATOLOGY RESEARCH

Toll-like receptors in acute liver injury and regeneration

(2011) Yongyan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH

(2011) Erwin Gäbele et al.   JOURNAL OF HEPATOLOGY

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

(2010) Chantal A Rivera et al.   BMC GASTROENTEROLOGY

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver

(2010) Kumaravelu Jagavelu et al.   HEPATOLOGY

Flagellin delays spontaneous human neutrophil apoptosis

(2010) Gabriela V Salamone et al.   LABORATORY INVESTIGATION

Toll-Like Receptor Signaling and Liver Fibrosis

(2010) Tomonori Aoyama et al.   Gastroenterology Research and Practice

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Pioglitazone Inhibits Toll-Like Receptor Expression and Activity in Human Monocytes and db/db Mice

(2009) Mohan R. Dasu et al.   ENDOCRINOLOGY

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

(2009) Marie A. Hildebrandt et al.   GASTROENTEROLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

(2009) Jun Wu et al.   IMMUNOLOGY

Role of TLR9 in hepatic stellate cells and experimental liver fibrosis

(2008) Erwin Gäbele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY