Article
Biochemistry & Molecular Biology
Dario E. Iglesias, Eleonora Cremonini, Shelly N. Hester, Steven M. Wood, Mark Bartlett, Cesar G. Fraga, Patricia I. Oteiza
Summary: This study found that supplementation with an anthocyanin-rich extract can prevent or reverse the damage to colonic physiology caused by a high-fat diet, possibly through the regulation of TLR-4 and redox-regulated signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Liuqiao Sun, Xuying Tan, Xiaoping Liang, Hangjun Chen, Qian Ou, Qiongmei Wu, Xinxue Yu, Hanqing Zhao, Qiaoli Huang, Zehua Yi, Jun Wei, Feng Wu, Huilian Zhu, Lijun Wang
Summary: Maternal betaine supplementation alleviates NAFLD in offspring through regulating gut microbiota and SCFAs.
Article
Neurosciences
Amanda N. Carey, Giulia Pintea, Shelby Van Leuven, Kelsea R. Gildawie, Laura Squiccimara, Elizabeth Fine, Abigail Rovnak, Mark Harrington
Summary: Research shows that red raspberry may mitigate the effects of high-fat diets on brain and behavior, improving cognitive functions and learning abilities. Mice fed diets supplemented with red raspberry demonstrated better performance in behavioral tests and biochemical assays. Further research with human subjects is needed to confirm the potential benefits of red raspberry in preventing aging and neurodegenerative diseases.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Food Science & Technology
Dipsikha Biswas, A. B. K. H. De Silva, Angella Mercer, Shreya Sarkar, Petra Kienesberger, Morgan Langille, H. P. Vasantha Rupasinghe, Thomas Pulinilkunnil
Summary: Haskap berry, enriched in anthocyanin C3G, can attenuate weight gain, reduce hepatic lipid content, and improve glucose homeostasis during obesity development by suppressing key lipogenic gene expression and modulating gut microbiota composition.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Pharmacology & Pharmacy
Xiao-Han Tang, Marta Melis, Karen Mai, Lorraine J. Gudas, Steven E. Trasino
Summary: This study demonstrated the potential anti-ALD properties of fenretinide in a mouse model of chronic ethanol exposure, showing its ability to modulate intestinal permeability, reduce endotoxemia, and decrease inflammation, suggesting further investigation as a potential anti-ALD drug.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Xingjian Wen, Hejing Liu, Xiaoling Luo, Li Lui, Jiuyu Fan, Yajing Xing, Jia Wang, Xingfang Qiao, Na Li, Guixue Wang
Summary: Supplementation of L. plantarum ATCC 14917 can alleviate weight gain, improve hepatic steatosis and serum lipid metabolism, and ameliorate HFD-induced inflammation in rats fed with a high-fat diet.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruozhi Zhao, Bo Xiang, Vernon W. Dolinsky, Min Xia, Garry X. Shen
Summary: The study demonstrated that Saskatoon berry powder (SBp) and its active component cyanidin-3-glucoside (C3G) have significant alleviating effects on HFHS diet-induced hepatic steatosis in mice, reducing high blood glucose, liver lipid deposition, insulin resistance, and chronic inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Lian Xiang, Tingwan Du, Jingjing Zhang, Yuanfan Zhang, Yanqiu Zhou, Yueying Zhao, Yong Zhou, Ling Ma
Summary: VD3 supplementation has inhibitory effects on weight gain, reduces blood lipids and inflammatory factors, and improves endotoxemia and gut barrier function in obese mice. It also increases the alpha-diversity of gut microbiota, reduces the relative abundance of some pathogenic bacteria, and increases the relative abundance of some beneficial bacteria. The low-dose and high-dose groups show better effects.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Daniel Zogona, Abel Wend-Soo Zongo, Abdeen E. Elkhedir, Mahmoud Salah, Mingfang Tao, Rong Li, Ting Wu, Xiaoyun Xu
Summary: This study investigated the protective effects and mechanisms of red raspberry (RR) on alcohol-related disorders in mice. The results showed that RR supplementation could reduce liver injury and improve oxidative stress and gut microbiota dysbiosis caused by chronic alcohol consumption. Thus, RR may be a potential supplement for improving alcoholic liver disease.
Article
Chemistry, Applied
Qiyan Lyu, Hongting Deng, Shunxin Wang, Hesham El-Seedi, Hui Cao, Lei Chen, Hui Teng
Summary: This study aims to investigate the effects of casein/cyanidin-3-O-glucoside nanoparticles (CsC3G) on gut microbiota disorders induced by a high-fat diet. In C57BL/6 mice fed a high-fat diet, Cs-C3G improved fat accumulation and liver oxidative stress. Cs-C3G, as a dietary supplement, restored the abundance and diversity of gut microbiota, decreased the ratio of Firmicutes to Bacteroidetes, increased beneficial microorganisms, and reduced opportunistic pathogenic bacteria. Overall, Cs-C3G regulated the disturbance of gut microbiota, preventing HFD-induced obesity and liver damage.
Article
Biochemistry & Molecular Biology
Dhafer Y. Alhareth, Abdulrazaq Alanazi, Wael A. Alanazi, Mushtaq A. Ansari, Mahmoud N. Nagi, Sheikh F. Ahmad, Mohamed S. M. Attia, Ahmed Nadeem, Saleh A. Bakheet, Sabry M. Attia
Summary: This study found that the proteasome inhibitor carfilzomib can protect against acute liver failure (ALF) induced by LPS/GalN/DMSO in mice by inhibiting NF-kB, reducing inflammatory mediators, oxidative stress, and apoptosis, suggesting its potential as a therapeutic agent for ALF.
Article
Biochemistry & Molecular Biology
Oluwanifemi Esther Bolatimi, Kimberly Z. Head, Jianzhu Luo, Tyler C. Gripshover, Qian Lin, Ngozi V. Adiele, Walter H. Watson, Caitlin Wilkerson, Lu Cai, Matthew C. Cave, Jamie L. Young
Summary: The pathogenesis of NAFLD is associated with zinc deficiency. Zinc supplementation does not have therapeutic effects on established NAFLD. Our study suggests that 8-week zinc supplementation cannot reverse established NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Food Science & Technology
Ruiqian Duan, Kai Huang, Xiao Guan, Sen Li, Jian Xia, Meng Shen, Zhu Sun, Zhiquan Yu
Summary: The study found that Tectorigenin (Tg) can alleviate NAFLD by mediating the liver-gut axis, mainly manifested in improving lipid metabolism abnormalities, restoring intestinal barrier, inhibiting pro-inflammatory cytokines release, and affecting intestinal microbiota.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Riitta Ryyti, Antti Pemmari, Rainer Peltola, Mari Hamalainen, Eeva Moilanen
Summary: The study explored the effects of lingonberry supplementation on hepatic gene expression in a mouse model of high-fat diet-induced obesity. Results suggest that lingonberry supplementation can prevent adverse changes in the liver induced by a high-fat diet, potentially preventing the development of NAFLD and its comorbidities.
Article
Biochemistry & Molecular Biology
Dario E. Iglesias, Eleonora Cremonini, Cesar G. Fraga, Patricia Oteiza
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Eleonora Cremonini, Dario E. Iglesias, Jiye Kang, Giovanni E. Lombardo, Zahra Mostofinejad, Ziwei Wang, Wei Zhu, Patricia Oteiza
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Nutrition & Dietetics
Eleonora Cremonini, Elena Daveri, Angela Mastaloudis, Patricia Oteiza
Summary: The study showed that (-)-epicatechin and various anthocyanins increased GLP-1 secretion in mice, regulating GLP-1 metabolism and positively impacting glucose homeostasis.
JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Patricia Oteiza, Cesar G. Fraga, Monica Galleano
Summary: The review explores the relationship between flavonoid consumption, oxidative stress mitigation, and improvement of human diseases. It focuses on the role of (-)-epicatechin in inflammation, endothelial dysfunction/hypertension, and insulin resistance/diabetes, and discusses the indirect antioxidant actions of EC and its metabolites in these pathologies. Human studies show promising results regarding the beneficial effects of EC on disease biomarkers, but more research is needed to establish conclusive associations between oxidative stress biomarkers and flavonoid consumption. The discovery of metabolites as reliable markers of flavonoid intake offers a powerful tool for linking flavonoid consumption to disease prevention and oxidative stress mitigation in human populations.
Article
Gastroenterology & Hepatology
Cecilia C. Garcia, Barbara Piotrkowski, Placida Baz, Daniel Poncino, Javier Benavides, Luis Colombato, Maria Laura Reyes Toso, Silvina Yantorno, Valeria Descalzi, Gabriel E. Gondolesi, Cesar G. Fraga, Alejandra C. Chernavsky
Summary: Resistin regulates the redox homeostasis in mononuclear leukocytes, with a decreased response to resistin in leukocytes from NAFLD patients associated with impaired redox homeostasis.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Food Science & Technology
Dario E. Iglesias, Eleonora Cremonini, Patricia Oteiza, Cesar G. Fraga
Summary: This study investigates the effects of curcumin in inhibiting inflammation, oxidative stress, and loss of intestinal barrier integrity induced by TNF alpha. The results suggest that curcumin can mitigate these undesired outcomes by inhibiting the activation of NF-kB, ERK1/2, and JNK pathways.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Physiology
Ezequiel J. Hid, Juana Mosele, Paula D. Prince, Cesar G. Fraga, Monica Galleano
Summary: This review summarizes experimental evidence on the beneficial effects of (-)-epicatechin (EC) attenuating major cardiometabolic risk factors, including dyslipidemias, obesity, hyperglycemia, and hypertension. The assessment of EC metabolism highlights the importance of both host metabolism-derived conjugated-EC metabolites and microbiota-derived species. EC appears to have significant effects on regulating oxidant production, nitric oxide production, and energy homeostasis in processes associated with cardiometabolic diseases.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Cremonini, Elena Daveri, Dario E. Iglesias, Jiye Kang, Ziwei Wang, Russell Gray, Angela Mastaloudis, Colin D. Kay, Shelly N. Hester, Steven M. Wood, Cesar G. Fraga, Patricia Oteiza
Summary: This study investigated the effects of a cyanidin-and delphinidin-rich extract on the postprandial dysmetabolism, inflammation, and insulin signaling triggered by a high fat meal. The results showed that the extract reduced the negative effects associated with postprandial dysmetabolism and regulated glycemia and lipidemia.
Article
Biochemistry & Molecular Biology
Dario E. Iglesias, Eleonora Cremonini, Shelly N. Hester, Steven M. Wood, Mark Bartlett, Cesar G. Fraga, Patricia I. Oteiza
Summary: This study found that supplementation with an anthocyanin-rich extract can prevent or reverse the damage to colonic physiology caused by a high-fat diet, possibly through the regulation of TLR-4 and redox-regulated signaling.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Patricia I. Oteiza, Eleonora Cremonini, Cesar G. Fraga
Summary: Anthocyanins, abundant flavonoids in our diet, have been associated with various health benefits. Their actions in the gastrointestinal tract can explain their local and systemic effects on health.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ezequiel J. Hid, Laura Fischerman, Barbara Piotrkowski, Maria C. Litterio, Cesar G. Fraga, Monica Galleano
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.