Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-κB signaling pathway

Hepatocytes derived increased SAA1 promotes intrahepatic platelet aggregation and aggravates liver inflammation in NAFLD

(2021) Daoyuan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

(2020) Dan Liu et al.   Cell Metabolism

iRhom2 promotes hepatic steatosis by activating MAP3K7‐dependent pathway

(2020) Minxuan Xu et al.   HEPATOLOGY

Silencing of SAA1 inhibits palmitate- or high-fat diet induced insulin resistance through suppression of the NF-κB pathway

(2019) Yong Wang et al.   MOLECULAR MEDICINE

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation

(2019) Jingjing Ben et al.   Nature Communications

Serum amyloid A levels in patients with liver diseases

(2019) Zi-Ying Yuan et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

(2019) June-Yong Lee et al.   CELL

TRUSS exacerbates NAFLD development by promoting IκBα degradation

(2018) Chang-Jiang Yu et al.   HEPATOLOGY

Improvement of hepatic fibrosis and patient-reported outcomes in non-alcoholic steatohepatitis treated with selonsertib

(2018) Zobair M. Younossi et al.   LIVER INTERNATIONAL

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Serum amyloid A promotes LPS clearance and suppresses LPS‐induced inflammation and tissue injury

(2018) Ni Cheng et al.   EMBO REPORTS

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Serum amyloid A – a review

(2018) George H. Sack   MOLECULAR MEDICINE

Role of Innate Immune Signaling in Non-Alcoholic Fatty Liver Disease

(2018) Jingjing Cai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

(2017) So Yeon Kim et al.   Nature Communications

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Efficacy and safety study of cenicriviroc for the treatment of non-alcoholic steatohepatitis in adult subjects with liver fibrosis: CENTAUR Phase 2b study design

(2016) Scott Friedman et al.   Contemporary Clinical Trials

The cytokine-serum amyloid A-chemokine network

(2016) Mieke De Buck et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Serum amyloid A links endotoxaemia to weight gain and insulin resistance in mice

(2016) Edson M. de Oliveira et al.   DIABETOLOGIA

Serum amyloid A1: Structure, function and gene polymorphism

(2016) Lei Sun et al.   GENE

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

Emerging functions of serum amyloid A in inflammation

(2015) Richard D. Ye et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

(2014) Xiang Zhang et al.   JOURNAL OF HEPATOLOGY

Serum Amyloid A Induces CCL2 Production via Formyl Peptide Receptor-Like 1-Mediated Signaling in Human Monocytes

(2014) H. Y. Lee et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TLR2 Is a Functional Receptor for Acute-Phase Serum Amyloid A

(2014) N. Cheng et al.   JOURNAL OF IMMUNOLOGY

Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis

(2014) J. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

(2014) Lin Jia et al.   Nature Communications

SAA does not induce cytokine production in physiological conditions

(2012) Myung-Hee Kim et al.   CYTOKINE

Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study

(2012) C. Marzi et al.   DIABETES CARE

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice

(2011) J. L. Ather et al.   JOURNAL OF IMMUNOLOGY

Serum Amyloid A Induces Lipolysis by Downregulating Perilipin Through ERK1/2 and PKA Signaling Pathways

(2011) Lih R. Liu et al.   Obesity

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Targeting major vault protein in senescence-associated apoptosis resistance

(2009) Sung Jin Ryu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Is serum amyloid A an endogenous TLR4 agonist?

(2008) Silvana Sandri et al.   JOURNAL OF LEUKOCYTE BIOLOGY