Article
Agriculture, Dairy & Animal Science
Jinze Li, Qiuke Li, Qianhui Wu, Nan Gao, Zhihua Wang, Yang Yang, Anshan Shan
Summary: This study investigated the protective effect of exopolysaccharides (EPSs) from Lactobacillus rhamnosus GG (LGG) on Salmonella typhimurium (S.T)-infected mice intestines. The results showed that high-dose EPSs improved weight loss, reduced intestinal inflammation and oxidative damage caused by S.T infection, and inhibited the expression of key proteins in the TLR4/NF-κB/MAPK signaling pathway.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Microbiology
Jinhee Kim, Iyshwarya Balasubramanian, Sheila Bandyopadhyay, Ian Nadler, Rajbir Singh, Danielle Harlan, Amanda Bumber, Yuling He, Lee J. Kerkhof, Nan Gao, Xiaoyang Su, Ronaldo P. Ferraris
Summary: This study delves into the colonization of P. acnes by Lactobacillus rhamnosus GG (LGG) and its impact on metabolites and inflammatory responses. Results show that co-association of LGG significantly reduces P. acnes abundance in the gut and has a significant impact on the host's metabolite output and inflammatory response.
Article
Gastroenterology & Hepatology
Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones
Summary: The study shows that oral administration of Lactobacillus rhamnosus GG can enhance colonic CD8 T-cell responses in mice and reduce tumor burden. This suggests the potential use of LGG to augment antitumor immune responses in colorectal cancer patients and increase the efficacy of immunotherapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Microbiology
Alain Cuna, Marianne Nsumu, Heather L. Menden, Susana Chavez-Bueno, Venkatesh Sampath
Summary: Peripartum antibiotics increase the risk of NEC and impair intestinal proliferation in newborns. However, supplementation with the probiotic Lactobacillus rhamnosus GG (LGG) can mitigate gut injury caused by antibiotics and restore intestinal proliferation by activating the Gpr81-Wnt pathway. Therefore, postnatal probiotics may be effective in reducing the risk of NEC associated with peripartum antibiotic exposure in preterm infants.
Article
Food Science & Technology
Srijita Sireswar, Gargi Dey, Sutapa Biswas
Summary: The study found that a sea buckthorn beverage fortified with probiotics demonstrated better restorative potential on intestinal barrier function and mucosal damage, stronger antioxidant activity, and inhibition of Toll-like receptor expression and pro-inflammatory gene upregulation induced by DSS in zebrafish.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Oncology
Xiang Liu, Ge Jin, Qiang Tang, Shumin Huang, Yujie Zhang, Yue Sun, Tianyu Liu, Zixuan Guo, Cheng Yang, Bangmao Wang, Kui Jiang, Weilong Zhong, Hailong Cao
Summary: Early life colonisation with Lactobacillus rhamnosus GG (LGG) can inhibit intestinal tumour formation in offspring by influencing gut microbiota composition and regulating signaling pathways.
BRITISH JOURNAL OF CANCER
(2022)
Article
Nutrition & Dietetics
Lufang Chen, Shumin Li, Chunting Peng, Qifeng Gui, Jinyou Li, Zherong Xu, Yunmei Yang
Summary: Disruption of the intestinal barrier is a cause and consequence of sepsis. Intestinal stem cell (ISC) proliferation and differentiation play a role in regenerating the intestinal epithelial cells and repairing the damaged intestinal mucosal barrier. This study demonstrates that treatment with Lactobacillus rhamnosus GG (LGG) improves the survival rate of septic mice and promotes colon epithelial cell proliferation. In vitro experiments show that LGG supernatant protects colonoids from TNF-alpha-induced damage. The LGG-induced barrier repair process is associated with increased expression of Lgr5(+) and lysozyme(+) cells, potentially mediated by the upregulation of IL-17, retinol metabolism, NF-kappa B, and the MAPK signaling pathways.
Article
Biotechnology & Applied Microbiology
Taiyu Zhai, Wenbo Ren, Pingping Wang, Lei Zheng
Summary: Gut microbiota plays an important role in atherosclerosis, and probiotic Lactobacillus rhamnosus GG can effectively inhibit the generation of AS plaques. It participates in the antiatherosclerotic mechanism by altering the composition of gut microbiota and metabolites.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yongsong Bai, Qingwei Meng, Cheng Wang, Kaidi Ma, Jibo Li, Jianping Li, Anshan Shan
Summary: This study demonstrates that Lactobacillus rhamnosus GG (LGG) improves deoxynivalenol (DON)-induced anorexia by modulating gut microbiota. LGG enhances intestinal barrier function, reduces intestinal inflammation, promotes food intake, and decreases weight loss. Antibiotic treatment and fecal microbiota transplant experiments confirm that gut microbiota is the primary vector for DON toxic effects and an essential mediator of LGG protection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zhengjie Wu, Qiaomai Xu, Silan Gu, Qiangqiang Wang, Yunbo Chen, Longxian Lv, Beiwen Zheng, Kaicen Wang, Shuting Wang, Jiafeng Xia, Lanjuan Li
Summary: This study found that Lactobacillus rhamnosus GG (LGG) can promote the recovery of the intestinal microbiota and improve Clostridioides difficile infection (CDI). LGG has the potential to be used as a preventive treatment for CDI or in combination with antibiotics to reduce recurrence.
Article
Nutrition & Dietetics
Lingjun Tong, Xinyi Zhang, Haining Hao, Qiqi Liu, Zihan Zhou, Xi Liang, Tongjie Liu, Pimin Gong, Lanwei Zhang, Zhengyuan Zhai, Yanling Hao, Huaxi Yi
Summary: Probiotic LGG-EVs show potential in attenuating colitis by inhibiting the TLR4-NF-kappa B-NLRP3 signaling pathway, reducing the release of pro-inflammatory cytokines, and reshaping gut microbiota. These findings suggest a promising therapeutic approach for colitis using oral gavage of LGG-EVs.
Article
Food Science & Technology
Ko-Chung Tsui, Ting-Lin Yen, Chi-Jung Huang, Kun-Jing Hong
Summary: The study investigated the effects of pretreatment with Lactobacillus rhamnosus GG (LGG) on sepsis survival and alterations in gut microbiota, blood cytokines, and chemokines in a mouse model. Results showed that LGG improved survival from LPS-induced sepsis by altering gut microbiota and reducing the host immune system's reactivity to pathogens.
FOOD SCIENCE & NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Linxiu Wu, Xiaoyan Liu, Rongkang Hu, Yixuan Chen, Meifang Xiao, Bin Liu, Feng Zeng
Summary: The study demonstrates that the combination of APS and LGG as prebiotics can delay aging-related oxidative stress by reducing liver oxidation and lipid metabolism, as well as regulating gut microbiota.
Article
Medicine, Research & Experimental
Rossella Salemi, Silvia Vivarelli, Daria Ricci, Marina Scillato, Maria Santagati, Giuseppe Gattuso, Luca Falzone, Massimo Libra
Summary: This study found that LGG-SN has anti-proliferative activity against colon cancer and metastatic melanoma cells and enhances the efficacy of anti-cancer drugs. This suggests that LGG could be a new therapeutic approach in oncology to reduce chemotherapy-related side effects and overcome resistance issues, improving the treatment response in cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Kasey Schalich, Seesandra Rajagopala, Suman Das, Ryan O'Connell, Fang Yan
Summary: This study reveals the regulatory effects of intestinal epithelial cell-derived components on the expression and metabolism of Lactobacillus rhamnosus GG at the molecular level, providing mechanistic insights into the interactions between the gut microbiota and the host.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Z. Li, Y. Song, L. Liu, N. Hou, X. An, D. Zhan, Y. Li, L. Zhou, P. Li, L. Yu, J. Xia, Y. Zhang, J. Wang, X. Yang
CELL DEATH AND DIFFERENTIATION
(2017)
Article
Endocrinology & Metabolism
Linkang Zhou, Miao Yu, Muhammad Arshad, Wenmin Wang, Ye Lu, Jingyi Gong, Yangnan Gu, Peng Li, Li Xu
Article
Biochemistry & Molecular Biology
Miao Yu, Muhammad Arshad, Wenmin Wang, Dongyu Zhao, Li Xu, Linkang Zhou
LIPIDS IN HEALTH AND DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Wenxin Song, Qi Luo, Yuping Zhang, Linkang Zhou, Ye Liu, Zhilong Ma, Jianan Guo, Yuedong Huang, Lili Cheng, Ziyi Meng, Zicheng Li, Bin Zhang, Siqi Li, Sook Wah Yee, Hao Fan, Peng Li, Kathleen M. Giacomini, Ligong Chen
Article
Biochemistry & Molecular Biology
Lu Su, Linkang Zhou, Feng-Jung Chen, Huimin Wang, Hui Qian, Yuanyuan Sheng, Yuangang Zhu, Hua Yu, Xinqi Gong, Li'e Cai, Xuerui Yang, Li Xu, Tong-Jin Zhao, John Zhong Li, Xiao-Wei Chen, Peng Li
Article
Biochemistry & Molecular Biology
Xuelian Xiong, Henry Kuang, Sahar Ansari, Tongyu Liu, Jianke Gong, Shuai Wang, Xu-Yun Zhao, Yewei Ji, Chuan Li, Liang Guo, Linkang Zhou, Zhimin Chen, Paola Leon-Mimila, Meng Ting Chung, Katsuo Kurabayashi, Judy Opp, Francisco Campos-Perez, Hugo Villamil-Ramirez, Samuel Canizales-Quinteros, Robert Lyons, Carey N. Lumeng, Beiyan Zhou, Ling Qi, Adriana Huertas-Vazquez, Aldons J. Lusis, X. Z. Shawn Xu, Siming Li, Yonghao Yu, Jun Z. Li, Jiandie D. Lin
Article
Cell Biology
Qiqi Li, Qiuye Zhao, Junyu Zhang, Linkang Zhou, Wenhao Zhang, BoonTin Chua, Yan Chen, Li Xu, Peng Li
Article
Cell Biology
Ximing Du, Linkang Zhou, Yvette Celine Aw, Hoi Yin Mak, Yanqing Xu, James Rae, Wenmin Wang, Armeh Zadoorian, Sarah E. Hancock, Brenna Osborne, Xiang Chen, Jia-Wei Wu, Nigel Turner, Robert G. Parton, Peng Li, Hongyuan Yang
JOURNAL OF CELL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Xu-Yun Zhao, Linkang Zhou, Zhimin Chen, Yewei Ji, Xiaoling Peng, Ling Qi, Siming Li, Jiandie D. Lin
Article
Food Science & Technology
Liangkui Li, Lu Zhang, Linkang Zhou, Meijun Jin, Li Xu
Summary: Long-chain inulin can prevent high-fat diet-induced obesity and associated metabolic disorders, while short-chain inulin has a similar but less effective impact. Both inulin types can alter gut microbiota composition and increase the production of short-chain fatty acids (SCFAs). However, the reduced serum levels of essential fatty acids, vitamins B1 and B3 caused by high-fat diet were further decreased by both inulin supplements.
FOOD SCIENCE & NUTRITION
(2021)
Article
Cell Biology
Peng Zhang, Zhimin Chen, Henry Kuang, Tongyu Liu, Jiaqiang Zhu, Linkang Zhou, Qiuyu Wang, Xuelian Xiong, Ziyi Meng, Xiaoxue Qiu, Ramiah Jacks, Lu Liu, Siming Li, Carey N. Lumeng, Qing Li, Xiang Zhou, Jiandie D. Lin
Summary: This study reveals that NASH leads to the induction of tumor-associated macrophages and depletion of cytotoxic T cells in the liver. Adipocyte-derived endocrine factor NRG4 plays a role in restraining this pathological reprogramming during NASH. NRG4 deficiency may exacerbate the development of tumor-prone liver immune microenvironment and NASH-related HCC, while NRG4 overexpression could have protective effects in mice. Recombinant NRG4-Fc fusion protein shows remarkable potency in suppressing HCC and prolonging survival in treated mice.
Article
Gastroenterology & Hepatology
Tongyu Liu, Qiuyu Wang, Linkang Zhou, Peng Zhang, Lin Mi, Xiaoxue Qiu, Zhimin Chen, Henry Kuang, Siming Li, Jiandie D. Lin
Summary: This study elucidates the molecular nature of intrahepatic paracrine signaling during NASH pathogenesis and uncovers potential therapeutic targets.
Article
Multidisciplinary Sciences
Terytty Yang Li, Lintao Song, Yu Sun, Jingyi Li, Cong Yi, Sin Man Lam, Dijin Xu, Linkang Zhou, Xiaotong Li, Ying Yang, Chen-Song Zhang, Changchuan Xie, Xi Huang, Guanghou Shui, Shu-Yong Lin, Karen Reue, Sheng-Cai Lin
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Guangang Gao, Feng-Jung Chen, Linkang Zhou, Lu Su, Dijin Xu, Li Xu, Peng Li
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Linkang Zhou