Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
出版年份 2022 全文链接
标题
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
作者
关键词
-
出版物
NATURE GENETICS
Volume 54, Issue 10, Pages 1479-1492
出版商
Springer Science and Business Media LLC
发表日期
2022-09-30
DOI
10.1038/s41588-022-01187-9
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
- (2021) Christoph Muus et al. NATURE MEDICINE
- Genome-wide enhancer maps link risk variants to disease genes
- (2021) Joseph Nasser et al. NATURE
- Pathway paradigms revealed from the genetics of inflammatory bowel disease
- (2020) Daniel B. Graham et al. NATURE
- Mechanisms of tissue and cell-type specificity in heritable traits and diseases
- (2020) Idan Hekselman et al. NATURE REVIEWS GENETICS
- Transcriptional and Cellular Diversity of the Human Heart
- (2020) Nathan R. Tucker et al. CIRCULATION
- The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic
- (2020) EUROPEAN JOURNAL OF HUMAN GENETICS
- Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease
- (2020) Julien Bryois et al. NATURE GENETICS
- Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
- (2020) Mingfeng Liao et al. NATURE MEDICINE
- Tubular secretion of creatinine and kidney function: an observational study
- (2020) Xuehan Zhang et al. BMC Nephrology
- Expansion of Neutrophils and Classical and Nonclassical Monocytes as a Hallmark in Relapsing-Remitting Multiple Sclerosis
- (2020) David Haschka et al. Frontiers in Immunology
- TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
- (2020) Francesca Cignarella et al. ACTA NEUROPATHOLOGICA
- Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis
- (2020) Arun C. Habermann et al. Science Advances
- Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
- (2020) Ming-Huei Chen et al. CELL
- The Human and Mouse Enteric Nervous System at Single-Cell Resolution
- (2020) Eugene Drokhlyansky et al. CELL
- Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer’s and Parkinson’s diseases
- (2020) M. Ryan Corces et al. NATURE GENETICS
- A molecular cell atlas of the human lung from single-cell RNA sequencing
- (2020) Kyle J. Travaglini et al. NATURE
- In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes
- (2020) Xin Jin et al. SCIENCE
- Interrogation of human hematopoiesis at single-cell and single-variant resolution
- (2019) Jacob C. Ulirsch et al. NATURE GENETICS
- Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities
- (2019) Hong Li et al. MOLECULAR PSYCHIATRY
- Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease
- (2019) Toufic Mayassi et al. CELL
- Molecular Classification and Comparative Taxonomics of Foveal and Peripheral Cells in Primate Retina
- (2019) Yi-Rong Peng et al. CELL
- Genomic Medicine–Progress, Pitfalls, and Promise
- (2019) Jay Shendure et al. CELL
- Tumour Necrosis Factor Alpha in Intestinal Homeostasis and Gut Related Diseases
- (2019) Barbara Ruder et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Single-cell transcriptomic analysis of Alzheimer’s disease
- (2019) Hansruedi Mathys et al. NATURE
- A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
- (2019) Quan Wang et al. NATURE NEUROSCIENCE
- Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis
- (2019) Christopher S. Smillie et al. CELL
- Neuronal vulnerability and multilineage diversity in multiple sclerosis
- (2019) Lucas Schirmer et al. NATURE
- Reconciling S-LDSC and LDAK functional enrichment estimates
- (2019) Steven Gazal et al. NATURE GENETICS
- A genetics-led approach defines the drug target landscape of 30 immune-related traits
- (2019) Hai Fang et al. NATURE GENETICS
- A cellular census of human lungs identifies novel cell states in health and in asthma
- (2019) Felipe A. Vieira Braga et al. NATURE MEDICINE
- Translational genomics and precision medicine: Moving from the lab to the clinic
- (2019) Eleftheria Zeggini et al. SCIENCE
- Spatiotemporal immune zonation of the human kidney
- (2019) Benjamin J. Stewart et al. SCIENCE
- Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities
- (2019) Anne-Laure Hemonnot et al. Frontiers in Aging Neuroscience
- Annotations capturing cell-type-specific TF binding explain a large fraction of disease heritability
- (2019) Bryce van de Geijn et al. HUMAN MOLECULAR GENETICS
- Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
- (2019) Charles P. Fulco et al. NATURE GENETICS
- Fast, sensitive and accurate integration of single-cell data with Harmony
- (2019) Ilya Korsunsky et al. NATURE METHODS
- Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
- (2018) Farhad Hormozdiari et al. NATURE GENETICS
- Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk
- (2018) Jian Zhou et al. NATURE GENETICS
- Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
- (2018) Hilary K. Finucane et al. NATURE GENETICS
- The importance of TCF4 gene in the etiology of recurrent depressive disorders
- (2018) Joanna Mossakowska-Wójcik et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Langerhans Cells: Sensing the Environment in Health and Disease
- (2018) Julie Deckers et al. Frontiers in Immunology
- A revised airway epithelial hierarchy includes CFTR-expressing ionocytes
- (2018) Daniel T. Montoro et al. NATURE
- A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
- (2018) Livnat Jerby-Arnon et al. CELL
- The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019
- (2018) Annalisa Buniello et al. NUCLEIC ACIDS RESEARCH
- Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
- (2018) Xiang Zhu et al. Nature Communications
- Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution
- (2018) Jeffrey B. Cheng et al. Cell Reports
- Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
- (2017) Anastasia G. Efthymiou et al. Molecular Neurodegeneration
- Scaling single-cell genomics from phenomenology to mechanism
- (2017) Amos Tanay et al. NATURE
- Linkage disequilibrium–dependent architecture of human complex traits shows action of negative selection
- (2017) Steven Gazal et al. NATURE GENETICS
- Estimating the causal tissues for complex traits and diseases
- (2017) Halit Ongen et al. NATURE GENETICS
- Genome-Wide Significance for PCLO as a Gene for Major Depressive Disorder
- (2017) Hamdi Mbarek et al. Twin Research and Human Genetics
- Adipose tissue deficiency of hormone-sensitive lipase causes fatty liver in mice
- (2017) Bo Xia et al. PLoS Genetics
- Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
- (2016) Atray Dixit et al. CELL
- Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease
- (2016) Claudio Villegas-Llerena et al. CURRENT OPINION IN NEUROBIOLOGY
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- A global reference for human genetic variation
- (2015) Richard A. Gibbs et al. NATURE
- Partitioning heritability by functional annotation using genome-wide association summary statistics
- (2015) Hilary K Finucane et al. NATURE GENETICS
- Progress and promise in understanding the genetic basis of common diseases
- (2015) Alkes L. Price et al. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Genetics of inflammatory bowel disease from multifactorial to monogenic forms
- (2015) Anna Monica Bianco WORLD JOURNAL OF GASTROENTEROLOGY
- The dynamics of monocytes and microglia in Alzheimer’s disease
- (2015) Peter Thériault et al. Alzheimers Research & Therapy
- MAGMA: Generalized Gene-Set Analysis of GWAS Data
- (2015) Christiaan A. de Leeuw et al. PLoS Computational Biology
- Regulation of T Cell Immunity in Atopic Dermatitis by Microbes: The Yin and Yang of Cutaneous Inflammation
- (2015) Tilo Biedermann et al. Frontiers in Immunology
- Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits
- (2014) Joseph K. Pickrell AMERICAN JOURNAL OF HUMAN GENETICS
- Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+T cells
- (2014) John A. Altin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inflammatory demyelination induces glia alterations and ganglion cell loss in the retina of an experimental autoimmune encephalomyelitis model
- (2013) Lioba Horstmann et al. Journal of Neuroinflammation
- Dendritic cells in multiple sclerosis: key players in the immunopathogenesis, key players for new cellular immunotherapies?
- (2013) AH Nuyts et al. Multiple Sclerosis Journal
- Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
- (2012) G. Ciarimboli et al. CLINICAL CANCER RESEARCH
- Inflammation inhibits GABA transmission in multiple sclerosis
- (2012) Silvia Rossi et al. Multiple Sclerosis Journal
- Chromatin marks identify critical cell types for fine mapping complex trait variants
- (2012) Gosia Trynka et al. NATURE GENETICS
- Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system
- (2012) Susan M. Sunkin et al. NUCLEIC ACIDS RESEARCH
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Mapping and analysis of chromatin state dynamics in nine human cell types
- (2011) Jason Ernst et al. NATURE
- Role of the endothelium in inflammatory bowel diseases
- (2011) Walter E Cromer WORLD JOURNAL OF GASTROENTEROLOGY
- Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum
- (2010) Pei-Song Gao et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The Ets-1 transcription factor controls the development and function of natural regulatory T cells
- (2010) Enguerran Mouly et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The GABAergic deficit hypothesis of major depressive disorder
- (2010) B Luscher et al. MOLECULAR PSYCHIATRY
- Cardiac Metabolism and Arrhythmias
- (2009) Andreas S. Barth et al. Circulation-Arrhythmia and Electrophysiology
- Adipocyte metabolism and obesity: Fig. 1.
- (2008) Alan D. Attie et al. JOURNAL OF LIPID RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now