Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities

The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner

(2017) S C Page et al.   MOLECULAR PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Reelin and Neuropsychiatric Disorders

(2016) Kazuhiro Ishii et al.   Frontiers in Cellular Neuroscience

Type I bHLH Proteins Daughterless and Tcf4 Restrict Neurite Branching and Synapse Formation by Repressing Neurexin in Postmitotic Neurons

(2016) Mitchell D’Rozario et al.   Cell Reports

Neuronal Misplacement in Schizophrenia

(2015) Albert E. Ayoub et al.   BIOLOGICAL PSYCHIATRY

Nitric Oxide Synthase 1 Adaptor Protein, a Protein Implicated in Schizophrenia, Controls Radial Migration of Cortical Neurons

(2015) Damien Carrel et al.   BIOLOGICAL PSYCHIATRY

Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis

(2015) Robert A. Kozol et al.   HUMAN MOLECULAR GENETICS

Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex

(2014) Dino P. Leone et al.   CEREBRAL CORTEX

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

The emerging roles of TCF4 in disease and development

(2014) Marc P. Forrest et al.   TRENDS IN MOLECULAR MEDICINE

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

(2014) Wei-Qun Fang et al.   Cell Reports

De Novo Mutations in Moderate or Severe Intellectual Disability

(2014) Fadi F. Hamdan et al.   PLoS Genetics

Focal Adhesion Dynamics Are Altered in Schizophrenia

(2013) Yongjun Fan et al.   BIOLOGICAL PSYCHIATRY

Laminar and Columnar Development of Barrel Cortex Relies on Thalamocortical Neurotransmission

(2013) Hong Li et al.   NEURON

Cortical Evolution: Judge the Brain by Its Cover

(2013) Daniel H. Geschwind et al.   NEURON

POU-III Transcription Factors (Brn1, Brn2, and Oct6) Influence Neurogenesis, Molecular Identity, and Migratory Destination of Upper-Layer Cells of the Cerebral Cortex

(2012) Martin H. Dominguez et al.   CEREBRAL CORTEX

Pitt–Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects

(2012) Mari Sepp et al.   HUMAN MOLECULAR GENETICS

Functional analysis ofTCF4missense mutations that cause Pitt-Hopkins syndrome

(2012) Marc Forrest et al.   HUMAN MUTATION

TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders

(2012) K V Wirgenes et al.   Translational Psychiatry

Common variants at VRK2 and TCF4 conferring risk of schizophrenia

(2011) Stacy Steinberg et al.   HUMAN MOLECULAR GENETICS

The Schizophrenia Risk Allele C of the TCF4 rs9960767 Polymorphism Disrupts Sensorimotor Gating in Schizophrenia Spectrum and Healthy Volunteers

(2011) B. B. Quednow et al.   JOURNAL OF NEUROSCIENCE

Impairment of cognitive performance after reelin knockdown in the medial prefrontal cortex of pubertal or adult rats

(2011) Jan Brosda et al.   NEUROBIOLOGY OF DISEASE

Does subtle disturbance of neuronal migration contribute to schizophrenia and other neurodevelopmental disorders? Potential genetic mechanisms with possible treatment implications

(2010) Stephen I. Deutsch et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cux1 and Cux2 Regulate Dendritic Branching, Spine Morphology, and Synapses of the Upper Layer Neurons of the Cortex

(2010) Beatriz Cubelos et al.   NEURON

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational, functional, and expression studies of theTCF4gene in Pitt-Hopkins syndrome

(2009) Lo��c de Pontual et al.   HUMAN MUTATION

Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity

(2009) Christopher L. Frank et al.   NEURON

Decision by division: making cortical maps

(2009) Pasko Rakic et al.   TRENDS IN NEUROSCIENCES

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

Development of the human cerebral cortex: Boulder Committee revisited

(2008) Irina Bystron et al.   NATURE REVIEWS NEUROSCIENCE

Satb2 Regulates Callosal Projection Neuron Identity in the Developing Cerebral Cortex

(2008) Elizabeth A. Alcamo et al.   NEURON