标题
Translational genomics and precision medicine: Moving from the lab to the clinic
作者
关键词
-
出版物
SCIENCE
Volume 365, Issue 6460, Pages 1409-1413
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-09-27
DOI
10.1126/science.aax4588
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data
- (2019) Ioanna Tachmazidou et al. NATURE GENETICS
- Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
- (2019) Amy R. Bentley et al. NATURE GENETICS
- Clinical use of current polygenic risk scores may exacerbate health disparities
- (2019) Alicia R. Martin et al. NATURE GENETICS
- New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
- (2019) Nick Shrine et al. NATURE GENETICS
- Variation in the Plasma Membrane Monoamine Transporter (PMAT, Encoded in SLC29A4) and Organic Cation Transporter 1 (OCT1, Encoded in SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study
- (2019) Adem Y. Dawed et al. DIABETES CARE
- Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study
- (2019) Andrea L. Jorgensen et al. BMC Medicine
- Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood
- (2019) Amit V. Khera et al. CELL
- Roadmap for a precision-medicine initiative in the Nordic region
- (2019) Pål Rasmus Njølstad et al. NATURE GENETICS
- Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration
- (2019) Thomas J. Heesterbeek et al. Scientific Reports
- Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine
- (2019) Miriam S Udler et al. ENDOCRINE REVIEWS
- The next generation of precision medicine: observational studies, electronic health records, biobanks and continuous monitoring
- (2018) Benjamin S Glicksberg et al. HUMAN MOLECULAR GENETICS
- Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
- (2018) Eric R. Gamazon et al. NATURE GENETICS
- CAR T cell immunotherapy for human cancer
- (2018) Carl H. June et al. SCIENCE
- Disclosure of Personalized Rheumatoid Arthritis Risk Using Genetics, Biomarkers, and Lifestyle Factors to Motivate Health Behavior Improvements: A Randomized Controlled Trial
- (2018) Jeffrey A. Sparks et al. ARTHRITIS CARE & RESEARCH
- Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference
- (2018) Laura J. Corbin et al. Nature Communications
- Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
- (2018) Evangelos Evangelou et al. NATURE GENETICS
- Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis
- (2018) Jonathan Massey et al. PHARMACOGENOMICS JOURNAL
- Genome-wide association studies of brain imaging phenotypes in UK Biobank
- (2018) Lloyd T. Elliott et al. NATURE
- Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
- (2018) Anubha Mahajan et al. NATURE GENETICS
- Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
- (2018) Ayush Giri et al. NATURE GENETICS
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants
- (2018) Loes CA Rutten-Jacobs et al. BMJ-British Medical Journal
- Genetics and genetic testing for age-related macular degeneration
- (2017) A. Warwick et al. EYE
- The Human Cell Atlas: from vision to reality
- (2017) Orit Rozenblatt-Rosen et al. NATURE
- Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis
- (2017) Unnur Styrkarsdottir et al. NATURE GENETICS
- Genetic Risk, Lifestyle, and Coronary Artery Disease
- (2017) NEW ENGLAND JOURNAL OF MEDICINE
- Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
- (2017) Frederick E. Dewey et al. NEW ENGLAND JOURNAL OF MEDICINE
- Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
- (2017) Eleanor Wheeler et al. PLOS MEDICINE
- The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
- (2016) Hendrik G. Stunnenberg et al. CELL
- Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland
- (2016) Eleftheria Zeggini et al. DIABETOLOGIA
- Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
- (2016) Kaixin Zhou et al. NATURE GENETICS
- Association of HLA-DRB1 Haplotypes With Rheumatoid Arthritis Severity, Mortality, and Treatment Response
- (2015) Sebastien Viatte et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Personalized medicine: Time for one-person trials
- (2015) Nicholas J. Schork NATURE
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- The African Genome Variation Project shapes medical genetics in Africa
- (2014) Deepti Gurdasani et al. NATURE
- A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
- (2014) Ida Moltke et al. NATURE
- Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
- (2014) James Bluett et al. RHEUMATOLOGY
- Power and Predictive Accuracy of Polygenic Risk Scores
- (2013) Frank Dudbridge PLoS Genetics
- Personalized Medicine in Cystic Fibrosis
- (2012) John P. Clancy et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- The Worldwide Environment of Cardiovascular Disease: Prevalence, Diagnosis, Therapy, and Policy Issues
- (2012) Lawrence J. Laslett et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The challenge of predicting macular degeneration
- (2011) Beatrix Feigl et al. CURRENT MEDICAL RESEARCH AND OPINION
- A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis
- (2011) Max A. Seibold et al. NEW ENGLAND JOURNAL OF MEDICINE
- Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes
- (2009) David G. Clayton PLoS Genetics
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