Role of TREM2 in the Development of Neurodegenerative Diseases After Traumatic Brain Injury

Poor Corticospinal Motor Neuron Health Is Associated with Increased Symptom Severity in the Acute Phase Following Repetitive Mild TBI and Predicts Early ALS Onset in Genetically Predisposed Rodents

(2021) Mor R. Alkaslasi et al.   Brain Sciences

Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

(2021) Yifei Dong et al.   NATURE NEUROSCIENCE

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

(2021) Seung-Hye Lee et al.   NEURON

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Biological links between traumatic brain injury and Parkinson’s disease

(2020) Vedad Delic et al.   Acta Neuropathologica Communications

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

(2020) Francesca Cignarella et al.   ACTA NEUROPATHOLOGICA

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

(2020) Aleksandra Deczkowska et al.   CELL

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional insights from biophysical study of TREM2 interactions with apoE and Aβ 1‐42

(2020) Daniel L. Kober et al.   Alzheimers & Dementia

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

(2020) Brittani R. Price et al.   Journal of Neuroinflammation

Early brain biomarkers of post-traumatic seizures: initial report of the multicentre epilepsy bioinformatics study for antiepileptogenic therapy (EpiBioS4Rx) prospective study

(2020) Evan S. Lutkenhoff et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Diverse activities of von Willebrand factor in traumatic brain injury and associated coagulopathy

(2020) Xin Xu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

(2019) Li Zhong et al.   Nature Communications

Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury

(2019) Vincent Yi-Fong Su et al.   STEM CELLS

Traumatic brain injury in China

(2019) Ji-Yao Jiang et al.   LANCET NEUROLOGY

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

(2019) Danielle K. Sandsmark et al.   NEURON

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk

(2019) Yuetiva Deming et al.   Science Translational Medicine

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

(2019) Si Yun Ng et al.   Frontiers in Cellular Neuroscience

Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation

(2019) Francesca Grassivaro et al.   JOURNAL OF NEUROSCIENCE

Identification of target genes in neuroinflammation and neurodegeneration after traumatic brain injury in rats

(2019) Jianwei Zhao et al.   PeerJ

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease

(2018) Iryna Voytyuk et al.   BIOLOGICAL PSYCHIATRY

Triggering Receptor Expressed on Myeloid Cells-2 Expression Tracks With M2-Like Macrophage Activity and Disease Severity in COPD

(2018) Derek E. Byers et al.   CHEST

Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage

(2018) Maria J Perugorria et al.   GUT

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer’s disease variant TREM2R47Hon murine myeloid cell function

(2018) Qingwen Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathologic Thr175tau phosphorylation in CTE and CTE with ALS

(2018) Alexander J. Moszczynski et al.   NEUROLOGY

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease

(2018) Olga N. Kokiko-Cochran et al.   Frontiers in Immunology

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Spencer L James et al.   LANCET NEUROLOGY

New insights into the role of TREM2 in Alzheimer’s disease

(2018) Maud Gratuze et al.   Molecular Neurodegeneration

The research agenda for trauma critical care

(2017) Karim Asehnoune et al.   INTENSIVE CARE MEDICINE

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

(2017) Honghua Zheng et al.   JOURNAL OF NEUROSCIENCE

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

(2017) Maha Saber et al.   JOURNAL OF NEUROTRAUMA

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

(2017) Andrew I R Maas et al.   LANCET NEUROLOGY

DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury

(2017) Liu Yang et al.   METABOLIC BRAIN DISEASE

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

(2017) Yasir N. Jassam et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

TREM2, Microglia, and Neurodegenerative Diseases

(2017) Felix L. Yeh et al.   TRENDS IN MOLECULAR MEDICINE

Alzheimer’s disease and chronic traumatic encephalopathy: Distinct but possibly overlapping disease entities

(2016) Ryan C. Turner et al.   BRAIN INJURY

Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?

(2016) Patricia M. Washington et al.   EXPERIMENTAL NEUROLOGY

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

(2016) M. Kobayashi et al.   JOURNAL OF NEUROSCIENCE

TREM2 variants: new keys to decipher Alzheimer disease pathogenesis

(2016) Marco Colonna et al.   NATURE REVIEWS NEUROSCIENCE

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Traumatic Axonal Injury: Mechanisms and Translational Opportunities

(2016) Ciaran S. Hill et al.   TRENDS IN NEUROSCIENCES

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

(2016) Daniel L Kober et al.   eLife

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury

(2016) Tonny V. Veenith et al.   JAMA Neurology

Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings

(2016) Paul K. Crane et al.   JAMA Neurology

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

(2015) Li Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

(2015) Kangyun Wu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Long-Term Consequences of Traumatic Brain Injury: Current Status of Potential Mechanisms of Injury and Neurological Outcomes

(2015) Helen M. Bramlett et al.   JOURNAL OF NEUROTRAUMA

Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury

(2015) Kristina G. Witcher et al.   TRENDS IN NEUROSCIENCES

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Cognitive changes and dementia risk after traumatic brain injury: Implications for aging military personnel

(2014) Andrea S. Vincent et al.   Alzheimers & Dementia

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

The Glasgow Coma Scale at 40 years: standing the test of time

(2014) Graham Teasdale et al.   LANCET NEUROLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

Homozygous TREM2 mutation in a family with atypical frontotemporal dementia

(2014) Isabelle Le Ber et al.   NEUROBIOLOGY OF AGING

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

(2014) G. Kleinberger et al.   Science Translational Medicine

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma

(2014) Raquel C. Gardner et al.   JAMA Neurology

Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration

(2014) Richard P Tobin et al.   Acta Neuropathologica Communications

Triggering Receptor Expressed on Myeloid Cells-2 Protects against Polymicrobial Sepsis by Enhancing Bacterial Clearance

(2013) QiXing Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microstructural Basis of Contusion Expansion in Traumatic Brain Injury: Insights from Diffusion Tensor Imaging

(2013) Virginia FJ Newcombe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide

(2013) XIAOLING GAO et al.   Molecular Medicine Reports

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Head injury and risk of Parkinson disease: A systematic review and meta-analysis

(2013) Siavash Jafari et al.   MOVEMENT DISORDERS

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia

(2013) Serena Lattante et al.   NEUROBIOLOGY OF AGING

Insights into TREM2 biology by network analysis of human brain gene expression data

(2013) Paola Forabosco et al.   NEUROBIOLOGY OF AGING

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

(2013) Margarita Giraldo et al.   NEUROBIOLOGY OF AGING

A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

(2013) Rita Guerreiro et al.   NEUROBIOLOGY OF AGING

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia

(2013) Elise Cuyvers et al.   NEUROBIOLOGY OF AGING

Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon

(2013) Marek Ma   NEUROBIOLOGY OF DISEASE

The Significance of α-Synuclein, Amyloid-β and Tau Pathologies in Parkinson's Disease Progression and Related Dementia

(2013) Yaroslau Compta et al.   Neurodegenerative Diseases

 -Synuclein in CSF of patients with severe traumatic brain injury

(2013) S. Mondello et al.   NEUROLOGY

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease

(2013) Todd E Golde et al.   Alzheimers Research & Therapy

Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury

(2013) Miguel A Sosa et al.   Acta Neuropathologica Communications

Antioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injury

(2012) Brittany R. Bitner et al.   ACS Nano

Neuroaxonal Regeneration is More Pronounced in Early Multiple Sclerosis than in Traumatic Brain Injury Lesions

(2012) Lucas Schirmer et al.   BRAIN PATHOLOGY

Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response

(2012) Carmen Correale et al.   GASTROENTEROLOGY

Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung

(2012) M Habibzay et al.   Mucosal Immunology

The Neuropathology and Neurobiology of Traumatic Brain Injury

(2012) Kaj Blennow et al.   NEURON

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans

(2011) Victoria E. Johnson et al.   ACTA NEUROPATHOLOGICA

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia

(2011) C. Oudin et al.   BLOOD

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Coagulopathy After Isolated Severe Traumatic Brain Injury in Children

(2011) Peep Talving et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

A review of paroxysmal sympathetic hyperactivity after acquired brain injury

(2010) Iain Perkes et al.   ANNALS OF NEUROLOGY

α-Synuclein Levels Are Elevated in Cerebrospinal Fluid following Traumatic Brain Injury in Infants and Children: The Effect of Therapeutic Hypothermia

(2010) Erik Su et al.   DEVELOPMENTAL NEUROSCIENCE

TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy

(2010) Ann C. McKee et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2009) Rao Muralikrishna Adibhatla et al.   ANTIOXIDANTS & REDOX SIGNALING

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

NGF, DCX, and NSE upregulation correlates with severity and outcome of head trauma in children

(2009) A. Chiaretti et al.   NEUROLOGY

Mutations inTREM2lead to pure early-onset dementia without bone cysts

(2008) Eliane Chouery et al.   HUMAN MUTATION

Efficient colonic mucosal wound repair requires Trem2 signaling

(2008) H. Seno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA