Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region
出版年份 2020 全文链接
标题
Enhancing protective microglial activities with a dual function
TREM
2 antibody to the stalk region
作者
关键词
-
出版物
EMBO Molecular Medicine
Volume 12, Issue 4, Pages -
出版商
EMBO
发表日期
2020-03-10
DOI
10.15252/emmm.201911227
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
- (2020) Julia Marschallinger et al. NATURE NEUROSCIENCE
- TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge
- (2020) Alicia A. Nugent et al. NEURON
- Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
- (2019) Marc Suárez-Calvet et al. Molecular Neurodegeneration
- Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model
- (2019) Li Zhong et al. Nature Communications
- Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration
- (2019) Emily G. O’Koren et al. IMMUNITY
- Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism
- (2019) Julia K Götzl et al. EMBO Molecular Medicine
- Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease
- (2019) Michael F. Egan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner
- (2019) Diego Adhemar Jaitin et al. CELL
- TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
- (2019) Ana Griciuc et al. NEURON
- Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells
- (2019) Keiro Shirotani et al. Scientific Reports
- Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease
- (2019) Michael Ewers et al. Science Translational Medicine
- TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer’s disease variant TREM2R47Hon murine myeloid cell function
- (2018) Qingwen Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
- (2018) Wilbur M. Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice
- (2018) Carola Focke et al. JOURNAL OF NUCLEAR MEDICINE
- Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
- (2018) Samira Parhizkar et al. NATURE NEUROSCIENCE
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Soluble TREM2 induces inflammatory responses and enhances microglial survival
- (2017) Li Zhong et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Elucidating the Role of TREM2 in Alzheimer’s Disease
- (2017) Jason D. Ulrich et al. NEURON
- Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
- (2017) Christopher J. Bohlen et al. NEURON
- ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
- (2017) Dominik Feuerbach et al. NEUROSCIENCE LETTERS
- TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
- (2016) Xianyuan Xiang et al. EMBO Molecular Medicine
- sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers
- (2016) Marc Suárez‐Calvet et al. EMBO Molecular Medicine
- The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
- (2016) Jeff Sevigny et al. NATURE
- A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese
- (2016) Teng Jiang et al. NEUROBIOLOGY OF AGING
- How neuroinflammation contributes to neurodegeneration
- (2016) R. M. Ransohoff SCIENCE
- Early changes in CSF sTREM2 in dominantly inherited Alzheimers disease occur after amyloid deposition and neuronal injury
- (2016) M. Suarez-Calvet et al. Science Translational Medicine
- Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
- (2016) Peer-Hendrik Kuhn et al. eLife
- TREM2 regulates microglial cell activation in response to demyelination in vivo
- (2015) Claudia Cantoni et al. ACTA NEUROPATHOLOGICA
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- η-Secretase processing of APP inhibits neuronal activity in the hippocampus
- (2015) Michael Willem et al. NATURE
- Regulation of microglial survival and proliferation in health and diseases
- (2015) Tyler K. Ulland et al. SEMINARS IN IMMUNOLOGY
- Single App knock-in mouse models of Alzheimer's disease
- (2014) Takashi Saito et al. NATURE NEUROSCIENCE
- Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle
- (2014) Jens Niewoehner et al. NEURON
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- (2014) G. Kleinberger et al. Science Translational Medicine
- Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage
- (2013) Patrick Wunderlich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease
- (2013) Sruti Rayaprolu et al. Molecular Neurodegeneration
- Identification of a unique TGF-β–dependent molecular and functional signature in microglia
- (2013) Oleg Butovsky et al. NATURE NEUROSCIENCE
- A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family
- (2013) Rita Guerreiro et al. NEUROBIOLOGY OF AGING
- Heterozygous TREM2 mutations in frontotemporal dementia
- (2013) Barbara Borroni et al. NEUROBIOLOGY OF AGING
- Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia
- (2013) Elise Cuyvers et al. NEUROBIOLOGY OF AGING
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease
- (2011) Robin B. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice
- (2011) Jin Hee Kim et al. PLoS One
- Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
- (2011) Y. J. Yu et al. Science Translational Medicine
- β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators
- (2010) Richard M. Page et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started