Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes

Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

(2020) Colin Chih-Chien Wu et al.   CELL

Disome and Trisome Profiling Reveal Genome-wide Targets of Ribosome Quality Control

(2020) Sezen Meydan et al.   MOLECULAR CELL

Alkylative damage of mRNA leads to ribosome stalling and rescue by trans translation in bacteria

(2020) Erica N Thomas et al.   eLife

Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

(2019) Ken Ikeuchi et al.   EMBO JOURNAL

Activation of GCN2 by the ribosomal P-stalk

(2019) Alison J. Inglis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress

(2019) Colin Chih-Chien Wu et al.   MOLECULAR CELL

Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii

(2019) Leonardo Augusto et al.   PLoS Pathogens

Insights into the base-pairing preferences of 8-oxoguanosine on the ribosome

(2019) Erica N Thomas et al.   NUCLEIC ACIDS RESEARCH

Towards a model of GCN2 activation

(2019) Glenn R. Masson   BIOCHEMICAL SOCIETY TRANSACTIONS

How do cells cope with RNA damage and its consequences?

(2019) Liewei L. Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

(2019) Heather P Harding et al.   eLife

Oxidation and alkylation stresses activate ribosome-quality control

(2019) Liewei L. Yan et al.   Nature Communications

Gcn4 Binding in Coding Regions Can Activate Internal and Canonical 5′ Promoters in Yeast

(2018) Yashpal Rawal et al.   MOLECULAR CELL

Lack of 2'-O-methylation in the tRNA anticodon loop of two phylogenetically distant yeast species activates the general amino acid control pathway

(2018) Lu Han et al.   PLoS Genetics

ZNF598 Is a Quality Control Sensor of Collided Ribosomes

(2018) Szymon Juszkiewicz et al.   MOLECULAR CELL

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

(2017) Szymon Juszkiewicz et al.   MOLECULAR CELL

Ribosome Collision Is Critical for Quality Control during No-Go Decay

(2017) Carrie L. Simms et al.   MOLECULAR CELL

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation

(2017) Elayanambi Sundaramoorthy et al.   MOLECULAR CELL

Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation

(2017) Changjun You et al.   NUCLEIC ACIDS RESEARCH

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

(2017) Aitor Garzia et al.   Nature Communications

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

(2017) Yoshitaka Matsuo et al.   Nature Communications

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation

(2016) Ryuta Ishimura et al.   eLife

Structural basis for stop codon recognition in eukaryotes

(2015) Alan Brown et al.   NATURE

Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo

(2015) Sebastien Lageix et al.   PLoS Genetics

Dom34 Rescues Ribosomes in 3′ Untranslated Regions

(2014) Nicholas R. Guydosh et al.   CELL

Distinct Roles for Release Factor 1 and Release Factor 2 in Translational Quality Control

(2014) Alexandros D. Petropoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Active Role for the Ribosome in Determining the Fate of Oxidized mRNA

(2014) Carrie L. Simms et al.   Cell Reports

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Eukaryotic Release Factor 3 Is Required for Multiple Turnovers of Peptide Release Catalysis by Eukaryotic Release Factor 1

(2013) Daniel E. Eyler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligodendrocyte-Specific Activation of PERK Signaling Protects Mice against Experimental Autoimmune Encephalomyelitis

(2013) W. Lin et al.   JOURNAL OF NEUROSCIENCE

EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension

(2013) Mélanie Eyries et al.   NATURE GENETICS

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

(2013) Tao Ma et al.   NATURE NEUROSCIENCE

Targeting the unfolded protein response in disease

(2013) Claudio Hetz et al.   NATURE REVIEWS DRUG DISCOVERY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Increased Cerebrospinal Fluid Levels of Double-Stranded RNA-Dependant Protein Kinase in Alzheimer's Disease

(2012) François Mouton-Liger et al.   BIOLOGICAL PSYCHIATRY

Overexpression of Eukaryotic Translation Elongation Factor 3 Impairs Gcn2 Protein Activation

(2012) Jyothsna Visweswaraiah et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

A comprehensive analysis of translational missense errors in the yeast Saccharomyces cerevisiae

(2010) E. B. Kramer et al.   RNA

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Role of Mitogen-Activated Protein Kinase Sty1 in Regulation of Eukaryotic Initiation Factor 2α Kinases in Response to Environmental Stress inSchizosaccharomyces pombe

(2009) Juan José Berlanga et al.   EUKARYOTIC CELL