Spatiotemporal control of ERK pulse frequency coordinates fate decisions during mammary acinar morphogenesis

Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics

(2022) Coralie Dessauges et al.   Molecular Systems Biology

LITOS: a versatile LED illumination tool for optogenetic stimulation

(2022) Thomas Christoph Höhener et al.   Scientific Reports

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

(2021) Paolo Armando Gagliardi et al.   DEVELOPMENTAL CELL

Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination

(2021) Léo Valon et al.   DEVELOPMENTAL CELL

Surface-tension-induced budding drives alveologenesis in human mammary gland organoids

(2021) Pablo A. Fernández et al.   Nature Physics

A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control

(2020) Alexander G. Goglia et al.   Cell Systems

ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

(2020) Naoya Hino et al.   DEVELOPMENTAL CELL

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Theory of mechanochemical patterning and optimal migration in cell monolayers

(2020) Daniel Boocock et al.   Nature Physics

MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression

(2020) Timothy J Aikin et al.   eLife

Hydra image processor: 5-D GPU image analysis library with MATLAB and python wrappers

(2019) Eric Wait et al.   BIOINFORMATICS

ilastik: interactive machine learning for (bio)image analysis

(2019) Stuart Berg et al.   NATURE METHODS

Mining single-cell time-series datasets with Time Course Inspector

(2019) Maciej Dobrzyński et al.   BIOINFORMATICS

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Separating Touching Cells Using Pixel Replicated Elliptical Shape Models

(2018) Mark Winter et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

The Terminal End Bud: the Little Engine that Could

(2017) Ingrid S. Paine et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle

(2017) Asako Sakaue-Sawano et al.   MOLECULAR CELL

Linear Integration of ERK Activity Predominates over Persistence Detection in Fra-1 Regulation

(2017) Taryn E. Gillies et al.   Cell Systems

Multigene expression in stable CHO cell pools generated with the piggyBac transposon system

(2016) Sowmya Balasubramanian et al.   BIOTECHNOLOGY PROGRESS

Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging

(2016) Daria M. Shcherbakova et al.   Nature Communications

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses

(2015) Breanne Sparta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ActivatingPIK3CAMutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer

(2015) Christian D. Young et al.   MOLECULAR & CELLULAR PROTEOMICS

Frequency modulation of ERK activation dynamics rewires cell fate

(2015) H. Ryu et al.   Molecular Systems Biology

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

(2015) Toru Hiratsuka et al.   eLife

The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini

(2015) Aljona Gaiko-Shcherbak et al.   PLoS One

Visualization and correction of automated segmentation, tracking and lineaging from 5-D stem cell image sequences

(2014) Eric Wait et al.   BMC BIOINFORMATICS

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light

(2014) Nury Kim et al.   CHEMISTRY & BIOLOGY

Extracting meaning from biological imaging data

(2014) Andrew R. Cohen   MOLECULAR BIOLOGY OF THE CELL

Signalling dynamics in vertebrate segmentation

(2014) Alexis Hubaud et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

(2013) Kazuhiro Aoki et al.   MOLECULAR CELL

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Improving FRET dynamic range with bright green and red fluorescent proteins

(2012) Amy J Lam et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1

(2012) F M Berglund et al.   ONCOGENE

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

(2012) N Chen et al.   ONCOGENE

Physiological Levels of Pik3caH1047R Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors

(2012) Anjali Tikoo et al.   PLoS One

Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly

(2012) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-guided evolution of cyan fluorescent proteins towards a quantum yield of 93%

(2012) Joachim Goedhart et al.   Nature Communications

Programmed Cell-to-Cell Variability in Ras Activity Triggers Emergent Behaviors during Mammary Epithelial Morphogenesis

(2012) Jennifer S. Liu et al.   Cell Reports

Vertebrate neural stem cell segmentation, tracking and lineaging with validation and editing

(2011) Mark Winter et al.   Nature Protocols

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A hyperactive piggyBac transposase for mammalian applications

(2011) K. Yusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

(2010) J Lauring et al.   ONCOGENE

H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3

(2010) A Chakrabarty et al.   ONCOGENE

Automatic Summarization of Changes in Biological Image Sequences Using Algorithmic Information Theory

(2009) A.R. Cohen et al.   IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

BAG-1 overexpression attenuates luminal apoptosis in MCF-10A mammary epithelial cells through enhanced RAF-1 activation

(2009) L R Anderson et al.   ONCOGENE

Knockin of mutant PIK3CA activates multiple oncogenic pathways

(2009) John P. Gustin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust single-particle tracking in live-cell time-lapse sequences

(2008) Khuloud Jaqaman et al.   NATURE METHODS