Physiological Levels of Pik3caH1047R Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors
出版年份 2012 全文链接
标题
Physiological Levels of Pik3caH1047R Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ERα-Positive Tumors
作者
关键词
Mammary glands, Mouse models, Epithelial cells, Cell staining, Cell immortalization, Mutation, Immunohistochemistry techniques, DAPI staining
出版物
PLoS One
Volume 7, Issue 5, Pages e36924
出版商
Public Library of Science (PLoS)
发表日期
2012-05-31
DOI
10.1371/journal.pone.0036924
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice
- (2012) Kathryn M. Kinross et al. JOURNAL OF CLINICAL INVESTIGATION
- PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib
- (2011) Leiping Wang et al. BMC CANCER
- Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer
- (2011) E. Razis et al. BREAST CANCER RESEARCH AND TREATMENT
- Cooperation between Pik3ca and p53 Mutations in Mouse Mammary Tumor Formation
- (2011) J. R. Adams et al. CANCER RESEARCH
- Luminal Expression of PIK3CA Mutant H1047R in the Mammary Gland Induces Heterogeneous Tumors
- (2011) D. S. Meyer et al. CANCER RESEARCH
- Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms
- (2011) Pixu Liu et al. NATURE MEDICINE
- PIK3CA Mutations in In situ and Invasive Breast Carcinomas
- (2010) A. Miron et al. CANCER RESEARCH
- BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells
- (2010) Gemma Molyneux et al. Cell Stem Cell
- Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer
- (2010) Stefan S. Bozhanov et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer
- (2010) S. Loi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma
- (2009) Jennifer Dunlap et al. BREAST CANCER RESEARCH AND TREATMENT
- AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
- (2009) Krishna M. Vasudevan et al. CANCER CELL
- PIK3CA Mutation Associates with Improved Outcome in Breast Cancer
- (2009) K. Kalinsky et al. CLINICAL CANCER RESEARCH
- PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast
- (2009) Hua Li et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
- (2009) Elgene Lim et al. NATURE MEDICINE
- PIK3CA Exon 20 Mutation is Independently Associated with a Poor Prognosis in Breast Cancer Patients
- (2008) Yuen-Liang Lai et al. ANNALS OF SURGICAL ONCOLOGY
- Activation of Phosphatidylinositol 3-Kinase by Membrane Localization of p110 Predisposes Mammary Glands to Neoplastic Transformation
- (2008) O. Renner et al. CANCER RESEARCH
- An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
- (2008) K. Stemke-Hale et al. CANCER RESEARCH
- Terminal end bud maintenance in mammary gland is dependent upon FGFR2b signaling
- (2008) Sara Parsa et al. DEVELOPMENTAL BIOLOGY
- Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis
- (2008) Pengfei Lu et al. DEVELOPMENTAL BIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started