Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

Astrocytic Target Mechanisms in Epilepsy

(2014) L. Heja   CURRENT MEDICINAL CHEMISTRY

Hippocampal expression of heat shock proteins in mesial temporal lobe epilepsy with psychiatric comorbidities and their relation to seizure outcome

(2014) Ludmyla Kandratavicius et al.   EPILEPSIA

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial

(2014) Merit E Cudkowicz et al.   LANCET NEUROLOGY

Analgesic Effect of a Single Preoperative Dose of the Antibiotic Ceftriaxone in Humans

(2013) Angela Macaluso et al.   JOURNAL OF PAIN

Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy

(2013) Longze Sha et al.   MOLECULAR NEUROBIOLOGY

Mechanisms of Glutamate Transport

(2013) Robert J. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Tanespimycin as Antitumor Therapy

(2012) Meletios-Athanassios Dimopoulos et al.   Clinical Lymphoma Myeloma & Leukemia

The intrahippocampal kainate model of temporal lobe epilepsy revisited: Epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats

(2012) Marta Rattka et al.   EPILEPSY RESEARCH

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

Protein Kinase C (PKC)-promoted Endocytosis of Glutamate Transporter GLT-1 Requires Ubiquitin Ligase Nedd4-2-dependent Ubiquitination but Not Phosphorylation

(2012) Noemí García-Tardón et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock protein 90 in neurodegenerative diseases

(2012) Wenjie Luo et al.   Molecular Neurodegeneration

Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

(2012) Qiongman Kong et al.   NEUROBIOLOGY OF DISEASE

Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy

(2012) Long-Ze Sha et al.   PLoS One

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

(2011) S. Modi et al.   CLINICAL CANCER RESEARCH

The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5

(2011) M S Weinberg et al.   GENE THERAPY

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Modulation of astrocyte glutamate transporters decreases seizures in a mouse model of Tuberous Sclerosis Complex

(2010) Ling-Hui Zeng et al.   NEUROBIOLOGY OF DISEASE

Reelin deficiency causes granule cell dispersion in epilepsy

(2009) Carola A. Haas et al.   EXPERIMENTAL BRAIN RESEARCH

Heat Shock Transcription Factor 1-activating Compounds Suppress Polyglutamine-induced Neurodegeneration through Induction of Multiple Molecular Chaperones

(2008) Nobuhiro Fujikake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester

(2007) Bala T.S. Susarla et al.   NEUROCHEMISTRY INTERNATIONAL