Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

The Importance of Preclinical Trial Timing - a Potential Reason for the Disconnect between mouse Studies and Human Clinical Trials in ALS

(2012) Qiongman Kong et al.   CNS Neuroscience & Therapeutics

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

(2012) Qiongman Kong et al.   NEUROBIOLOGY OF DISEASE

Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

(2011) Xuechao Xing et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

(2011) Marica Carbone et al.   NEUROCHEMISTRY INTERNATIONAL

YB-1 Binds to GluR2 mRNA and CaM1 mRNA in the Brain and Regulates their Translational Levels in an Activity-Dependent Manner

(2010) Toru Tanaka et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Riluzole, Neuroprotection and Amyotrophic Lateral Sclerosis

(2010) B.C. Cheah et al.   CURRENT MEDICINAL CHEMISTRY

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

Update on the use of memantine in Alzheimer’s disease

(2010) Rob Marum   Neuropsychiatric Disease and Treatment

Astrocyte-neuron interactions: Implications for epilepsy

(2009) E. E. Benarroch   NEUROLOGY

Design, power, and interpretation of studies in the standard murine model of ALS

(2008) Sean Scott et al.   Amyotrophic Lateral Sclerosis

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes in the Epileptic Brain

(2008) Jonathon Wetherington et al.   NEURON

Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS

(2008) Yueming Chang et al.   PLoS One

A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

(2008) Nico Melzer et al.   PLoS One

Progress in neuroprotective strategies for preventing epilepsy

(2007) M ACHARYA et al.   PROGRESS IN NEUROBIOLOGY