Article
Neurosciences
Aditi Sharma, Om Prakash Shah, Lalit Sharma, Monica Gulati, Tapan Behl, Asaad Khalid, Syam Mohan, Asim Najmi, Khalid Zoghebi
Summary: Misfolded and aggregated proteins are the main cause of neurodegenerative diseases, and molecular chaperones play a crucial role in controlling this process. Aging affects the function of molecular chaperones, leading to increased aggregation of misfolded proteins and the development of neurodegenerative diseases. Molecular chaperones are also linked to diseases such as Parkinson's, Huntington's, and Alzheimer's. Therefore, they have the potential to be therapeutic targets for brain disorders.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pia Roos-Mattjus, Lea Sistonen
Summary: Heat-shock factors (HSFs) are a family of transcription factors with a wide range of target genes, playing crucial roles in normal development and linked to various diseases such as neurodegenerative disorders and cancer. The regulatory mechanisms of HSFs and their specific target gene selection under different conditions remain unclear, with posttranslational modifications and interplay among family members being key regulatory mechanisms.
Review
Pharmacology & Pharmacy
Bram Van den Broek, Charlotte Wuyts, Joy Irobi
Summary: Extracellular vesicles and small heat shock proteins show therapeutic potential in neurodegenerative diseases, positively influencing neuroinflammation, central nervous system repair, and protein aggregation.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Chemistry, Medicinal
Subhabrata Chaudhury, Bradley M. Keegan, Brian S. J. Blagg
Summary: Heat shock proteins (Hsps) act as molecular chaperones and are involved in the activation of the heat shock response (HSR) to counter abnormal physiological conditions and stress, potentially helping in conditions such as cancer and neurodegenerative diseases. Cellular stress results in the upregulation of Hsp70 transcription to protect cells, with Hsp90 being the primary regulator of the HSR and a potential target for therapeutic interventions in neuropathies.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Multidisciplinary Sciences
Sharif Hasan Siddiqui, Mousumee Khan, Hosung Choe, Darae Kang, Kwanseob Shim
Summary: This study investigated the structure and functional expression of heat shock proteins (HSPs) in different chicken organs using meta-analysis. The results showed that the expression of HSPs varied among different organs and under different stress levels. Heat stress significantly changed the expression of HSP70 in the chicken liver. The findings highlight the diverse expression patterns of HSPs in chicken organs.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Feng Guo, Xiang Cheng, Boping Jing, Heshui Wu, Xin Jin
Summary: Pancreatic cancer is characterized by deregulated and constitutively activated NF-kappa B signaling. FGD3, which is downregulated in pancreatic cancer tissues, inhibits cancer cell proliferation, invasion, and metastasis by activating the NF-kappa B signaling pathway. These findings suggest a potential target for pancreatic cancer treatment.
Article
Biology
Rosemary N. Plagens, Isiah Mossiah, Karen S. Kim Guisbert, Eric Guisbert
Summary: Temperature stress has significant impacts on organismal physiology and molecular mechanisms, leading to endocytic defects and physiological changes. Molecular chaperones and transcription factors play important roles in addressing these issues.
Review
Cell Biology
Batoul Abi Zamer, Waseem El-Huneidi, Mohamed Ahmed Eladl, Jibran Sualeh Muhammad
Summary: HSPs play a crucial role in cancer by aiding cancer cells in developing resistance to chemotherapy. Targeting HSPs as a therapeutic strategy has shown promise in difficult-to-treat cancers such as CRC.
Article
Plant Sciences
Wen-Ya Ma, Qiu-Yun Qin, Ying-Ning Zou, Kamil Kuca, Bhoopander Giri, Qiang-Sheng Wu, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Khalid F. Almutairi, Elsayed Fathi Abd Allah, Yong-Jie Xu
Summary: AMF enhances drought tolerance in walnut by activating antioxidant defense systems and Hsfs transcription levels, reducing oxidative damage.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Toxicology
Benjamin J. Lang, Martin E. Guerrero, Thomas L. Prince, Yuka Okusha, Cristina Bonorino, Stuart K. Calderwood
Summary: Cells respond to protein-damaging stress by activating the Heat Shock Response (HSR), which plays a crucial role in determining cell survival or death. The modulation of HSR and its network have become attractive treatment strategies for neurodegenerative diseases and cancers. A detailed understanding of the mechanisms of HSR is necessary for the development of effective therapies, as important features of HSR continue to be uncovered.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Cell Biology
Gregory L. Blatch
Summary: Plasmodium falciparum, the parasite causing severe malaria in humans, has developed sophisticated mechanisms, including heat shock proteins, to maintain protein homeostasis during its invasion of host erythrocytes. This review examines the contribution of major chaperones, particularly Hsp70 and Hsp40 families, to proteostasis in malaria parasite-infected erythrocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Margaret K. Kurop, Cormac M. Huyen, John H. Kelly, Brian S. J. Blagg
Summary: The heat shock response is a conserved cellular pathway that activates heat shock proteins to alleviate stress and refold denatured proteins. Pathological conditions can negatively impact HSR function and lead to misfolded protein aggregation.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Laura Secli, Federica Fusella, Lidia Avalle, Mara Brancaccio
Summary: Heat shock proteins play crucial roles in cellular homeostasis and stress response, with extracellular heat shock proteins potentially contributing to cancer development and metastasis by supporting cancer hallmarks and modulating the tumor microenvironment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Klara Hellauer, Olga V. Oskolkova, Bernd Gesslbauer, Valery Bochkov
Summary: Oxidised phospholipids, such as OxPAPC, are recognized as danger-associated molecular patterns (DAMPs) that induce inflammation. This study identified six compounds that can inhibit the secretion of interleukin-8 by OxPAPC-treated endothelial cells. These compounds reduced the elevation of IL-8 mRNA and increased the induction of heat-shock proteins (HSPs). The findings suggest that proteostatic stress plays a role in the pro-inflammatory effects of OxPAPC, and stabilizing the proteome with HSPs or chemical chaperones can reduce these effects.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Penchala Narasimharao Meka, Eva Amatya, Sukhmanjit Kaur, Monimoy Banerjee, Ang Zuo, Rick T. Dobrowsky, Brian S. J. Blagg
Summary: This study investigated the efficacy of 3'- and 4'-substituted cyclohexyl scaffolds as noviomimetics in increasing mitochondrial bioenergetics, as a marker for cytoprotective potential, based on structure-activity relationship studies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Saki Shimada, Yuuka Muraoka, Kimihide Ibaraki, Toshiyuki Takano-Shimizu-Kouno, Hideki Yoshida, Masamitsu Yamaguchi
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Oncology
Ibuki Ueoka, Akari Takai, Mizuki Yamaguchi, Tomohiro Chiyonobu, Hideki Yoshida, Masamitsu Yamaguchi
EXPERIMENTAL CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Steven J. Marygold, Helen Attrill, Elena Speretta, Kate Warner, Michele Magrane, Maria Berloco, Sue Cotterill, Mitch McVey, Yikang Rong, Masamitsu Yamaguchi
Article
Biochemistry & Molecular Biology
Hang Thi Nguyet Pham, Hong Nguyen Tran, Phuong Thi Nguyen, Xoan Thi Le, Khoi Minh Nguyen, Sinh Viet Phan, Masanori Yoneyama, Kiyokazu Ogita, Taro Yamaguchi, William R. Folk, Masamitsu Yamaguchi, Kinzo Matsumoto
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Masamitsu Yamaguchi, Kentaro Omori, Satoshi Asada, Hideki Yoshida
Summary: ALS and CMT are common neurodegenerative disorders with significant phenotypic heterogeneity, potentially due to modifiers that influence disease characteristics. Epigenetic regulation of biological functions through gene expression may be an important mechanism in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Eric Hyrmeya Savadogo, Yui Shiomi, Junko Yasuda, Toshiharu Akino, Masamitsu Yamaguchi, Hideki Yoshida, Takanari Umegawachi, Ryo Tanaka, Dang Ngoc Anh Suong, Kenji Miura, Kazufumi Yazaki, Sakihito Kitajima
Summary: Genes of the PLAT protein family play a role in plant defense against insects through the involvement of anti-microbe or anti-insect proteins in laticifer cells. These genes induce an indirect insect resistance response in the host plant, as well as possibly causing direct cytotoxic effects on insects. Larval growth of insects is significantly affected by the expression of PLAT proteins from different plant species, highlighting the conserved anti-insect activity of the PLAT protein family in the plant kingdom.
Article
Biochemistry & Molecular Biology
Hang Thi Nguyet Pham, Hong Nguyen Tran, Xoan Thi Le, Ha Thi Do, Tue Trong Nguyen, Chien Le Nguyen, Hideki Yoshida, Masamistu Yamaguchi, Folk R. William, Kinzo Matsumoto
Summary: This study found that a chemically characterized extract from Ilex kudingcha can improve behavioral traits in a Drosophila melanogaster rugose mutant, resembling human Autism Spectrum Disorder (ASD) traits. The extract also increased synaptic bouton number in Drosophila rugose and altered gene expression in the mouse hippocampus. These results suggest the potential of Ilex kudingcha extract as a treatment for some forms of ASD.
NEUROCHEMICAL RESEARCH
(2021)
Article
Neurosciences
Yuuka Muraoka, Atsushi Nikaido, Ryosuke Kowada, Hiroshi Kimura, Masamitsu Yamaguchi, Hideki Yoshida
Summary: Mutations in the FIG 4 gene are associated with various disorders, possibly due to dysregulated epigenetics. HDAC1 has been identified as an important epigenetic regulator of FIG 4, suggesting potential therapeutic targets for FIG 4-related disorders such as CMT.
Correction
Oncology
Hisanori Matsubara, Reiji Tanaka, Tatsuya Tateishi, Hideki Yoshida, Masamitsu Yamaguchi, Takao Kataoka
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Oncology
Masamitsu Yamaguchi, Im-soon Lee, Salinee Jantrapirom, Kojiro Suda, Hideki Yoshida
Summary: Drosophila is being used as a model for studying human diseases, with functional homologues of a large percentage of human disease-related genes found in Drosophila. This review discusses Drosophila models targeting genes associated with ALS and CMT, highlighting potential therapeutic targets and diagnostic markers.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Ngoc-Lan Thi Nguyen, Ngoc-Dzung Thi Dang, Quang-Huy Dang, Van-Chuc Tran, Hoang-Long Vo, Masamitsu Yamaguchi, Thanh-Van Ta
Summary: The study found that the polymorphisms of Mucin 1 gene, specifically rs4072037 and rs2070803, are associated with gastric cancer risk, with the AA genotype potentially increasing risk while the AG genotype may lower it. Combining factors such as age, gender, alcoholism, and personal history of gastric disease significantly elevate the risk of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryosuke Kowada, Atsushi Kodani, Hiroyuki Ida, Masamitsu Yamaguchi, Im-Soon Lee, Yasushi Okada, Hideki Yoshida
Summary: The homolog of human SCO2, Scox, plays an essential role in mitochondrial function and locomotive behavior in Drosophila. Knockdown of Scox in glial cells impairs mitochondrial morphology and function, as well as locomotive behavior, mimicking the pathological phenotypes observed in humans with mutations in the SCO2 gene.
SCIENTIFIC REPORTS
(2021)
Correction
Multidisciplinary Sciences
Tomoki Hirashima, Ryo Tanaka, Masamitsu Yamaguchi, Hideki Yoshida
SCIENTIFIC REPORTS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Masamitsu Yamaguchi, Shinya Yamamoto
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yu Hiramatsu, Yuji Okamoto, Akiko Yoshimura, Jun-Hui Yuan, Masahiro Ando, Yujiro Higuchi, Akihiro Hashiguchi, Eiji Matsuura, Fumihito Nozaki, Tomohiro Kumada, Kei Murayama, Mikiya Suzuki, Yuki Yamamoto, Naoko Matsui, Yoshimichi Miyazaki, Masamitsu Yamaguchi, Youji Suzuki, Jun Mitsui, Hiroyuki Ishiura, Masaki Tanaka, Shinichi Morishita, Ichizo Nishino, Shoji Tsuji, Hiroshi Takashima
Summary: This study identified causative mutations in mitochondrial-related nuclear genes in suspected hereditary peripheral neuropathy patients. Whole-exome sequencing was performed on a large cohort of Japanese patients, and novel pathogenic variants were detected in four mitochondrial-related nuclear genes. These patients exhibited sensory and motor axonal polyneuropathy, along with central nervous system or multisystem involvements.
JOURNAL OF NEUROLOGY
(2022)