Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

Glial glutamate transport modulates dendritic spine head protrusions in the hippocampus

(2012) David Verbich et al.   GLIA

Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP

(2012) J. D. Pita-Almenar et al.   LEARNING & MEMORY

Increased glial glutamate transporter EAAT2 expression reduces epileptogenic processes following pilocarpine-induced status epilepticus

(2012) Qiongman Kong et al.   NEUROBIOLOGY OF DISEASE

Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

(2011) Xuechao Xing et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hippocampal glutamate transporter 1 (GLT-1) complex levels are paralleling memory training in the Multiple T-Maze in C57BL/6J mice

(2011) Seok Heo et al.   Brain Structure & Function

New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs

(2011) Salvatore Salomone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Seizures and Epilepsy in Alzheimer's Disease

(2011) Daniel Friedman et al.   CNS Neuroscience & Therapeutics

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex

(2011) Sophie Sokolow et al.   NEUROBIOLOGY OF DISEASE

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

(2011) Haythum O. Tayeb et al.   PHARMACOLOGY & THERAPEUTICS

Increased expression of cholesterol 24S-hydroxylase results in disruption of glial glutamate transporter EAAT2 association with lipid rafts: a potential role in Alzheimer’s disease

(2010) Guilian Tian et al.   JOURNAL OF NEUROCHEMISTRY

Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid  42 from Isolated Intact Nerve Terminals

(2010) S. H. Kim et al.   JOURNAL OF NEUROSCIENCE

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease

(2010) Heather A. Scott et al.   NEUROBIOLOGY OF AGING

Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory

(2010) Anita J Bechtholt-Gompf et al.   NEUROPSYCHOPHARMACOLOGY

Amyloid  -Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

(2009) R. Minkeviciene et al.   JOURNAL OF NEUROSCIENCE

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport

(2009) Alessandro Filosa et al.   NATURE NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

(2009) M. A. Carmona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of long-term memory for object recognition via HDAC inhibition

(2009) D. P. Stefanko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

β-Amyloid-related peptides potentiate K+-evoked glutamate release from adult rat hippocampal slices

(2008) D. Kabogo et al.   NEUROBIOLOGY OF AGING

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

(2007) Alireza Kashani et al.   NEUROBIOLOGY OF AGING