The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes

Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion

(2022) Johannes Westman et al.   Cell Reports

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

(2022) Simona Maria Migliano et al.   CURRENT OPINION IN CELL BIOLOGY

Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair

(2022) Willa Wen‐You Yim et al.   FEBS LETTERS

ESCRT-mediated membrane repair protects tumor-derived cells against T cell attack

(2022) Alex T. Ritter et al.   SCIENCE

Resisting attack by repairing the damage

(2022) Norma W. Andrews   SCIENCE

Ca2+-activated sphingomyelin scrambling and turnover mediate ESCRT-independent lysosomal repair

(2022) Patrick Niekamp et al.   Nature Communications

Snf7 spirals sense and alter membrane curvature

(2022) Nebojsa Jukic et al.   Nature Communications

Recruitment and organization of ESCRT-0 and ubiquitinated cargo via condensation

(2022) Sudeep Banjade et al.   Science Advances

ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

(2022) Marta Wróbel et al.   Life Science Alliance

Plant endosomes as protein sorting hubs

(2022) Ariadna González Solís et al.   FEBS LETTERS

Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery

(2022) Tomoyuki Hatano et al.   Nature Communications

Direct binding of ESCRT protein Chm7 to phosphatidic acid–rich membranes at nuclear envelope herniations

(2021) David J. Thaller et al.   JOURNAL OF CELL BIOLOGY

Sealing holes in cellular membranes

(2021) Yan Zhen et al.   EMBO JOURNAL

Repairing plasma membrane damage in regulated necrotic cell death

(2021) Rafael A. Espiritu   MOLECULAR BIOLOGY REPORTS

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

(2021) Maryam Alqabandi et al.   BMC BIOLOGY

Principles of membrane remodeling by dynamic ESCRT-III polymers

(2021) Anna-Katharina Pfitzner et al.   TRENDS IN CELL BIOLOGY

Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily

(2021) Jiwei Liu et al.   CELL

PspA adopts an ESCRT-III-like fold and remodels bacterial membranes

(2021) Benedikt Junglas et al.   CELL

Nuclear envelope remodelling during mitosis

(2021) Gautam Dey et al.   CURRENT OPINION IN CELL BIOLOGY

A  conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation

(2021) Weichao Zhang et al.   PLOS BIOLOGY

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody

(2021) Chiara Merigliano et al.   PLoS Genetics

Design principles of the ESCRT-III Vps24-Vps2 module

(2021) Sudeep Banjade et al.   eLife

CDK1 controls CHMP7-dependent nuclear envelope reformation

(2021) Alberto T Gatta et al.   eLife

The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

(2021) Samuel S. Wallis et al.   DEVELOPMENTAL CELL

ESCRT-III/Vps4 Controls Heterochromatin-Nuclear Envelope Attachments

(2020) Gerard H. Pieper et al.   DEVELOPMENTAL CELL

Lysosome biology in autophagy

(2020) Willa Wen-You Yim et al.   Cell Discovery

Autophagosome biogenesis: From membrane growth to closure

(2020) Thomas J. Melia et al.   JOURNAL OF CELL BIOLOGY

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation

(2020) Alexander von Appen et al.   NATURE

Membrane constriction and thinning by sequential ESCRT-III polymerization

(2020) Henry C. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission

(2020) Thomas G. Flower et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Flemmingsome reveals an ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 required for completion of cytokinesis

(2020) Cyril Addi et al.   Nature Communications

Anisotropic ESCRT-III architecture governs helical membrane tube formation

(2020) Joachim Moser von Filseck et al.   Nature Communications

Human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation

(2020) Aurélie Bertin et al.   Nature Communications

CHMPions of repair: Emerging perspectives on sensing and repairing the nuclear envelope barrier

(2020) C. Patrick Lusk et al.   CURRENT OPINION IN CELL BIOLOGY

ESCRT puts its thumb on the nanoscale: Fixing tiny holes in endolysosomes

(2020) Kevin P. Bohannon et al.   CURRENT OPINION IN CELL BIOLOGY

LRRK 2 activation controls the repair of damaged endomembranes in macrophages

(2020) Susanne Herbst et al.   EMBO JOURNAL

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

An ESCRT-III Polymerization Sequence Drives Membrane Deformation and Fission

(2020) Anna-Katharina Pfitzner et al.   CELL

HIV-1 Gag release from yeast reveals ESCRT interaction with the Gag N-terminal protein region

(2020) Birgit Meusser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ESCRTs – converging on mechanism

(2020) Mark Remec Pavlin et al.   JOURNAL OF CELL SCIENCE

The proteasome controls ESCRT-III–mediated cell division in an archaeon

(2020) Gabriel Tarrason Risa et al.   SCIENCE

Structure and assembly of ESCRT-III helical Vps24 filaments

(2020) Stefan T. Huber et al.   Science Advances

Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics

(2020) Lohans Pedrera et al.   CELL DEATH AND DIFFERENTIATION

Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes

(2020) John McCullough et al.   CURRENT BIOLOGY

ESCRT recruitment by the S. cerevisiae inner nuclear membrane protein Heh1 is regulated by Hub1-mediated alternative splicing

(2020) Matías Capella et al.   JOURNAL OF CELL SCIENCE

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection

(2019) Ana T. López-Jiménez et al.   PLoS Pathogens

Rab5-dependent autophagosome closure by ESCRT

(2019) Fan Zhou et al.   JOURNAL OF CELL BIOLOGY

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

(2019) David J Thaller et al.   eLife

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

(2019) Jessica Willan et al.   Oncogenesis

VPS4 triggers constriction and cleavage of ESCRT-III helical filaments

(2019) Sourav Maity et al.   Science Advances

Autophagosome closure by ESCRT: Vps21/RAB5-regulated ESCRT recruitment via an Atg17-Snf7 interaction

(2019) Fan Zhou et al.   Autophagy

A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission

(2019) Eva P. Karasmanis et al.   CURRENT BIOLOGY

Repair of nuclear ruptures requires barrier-to-autointegration factor

(2019) Charles T. Halfmann et al.   JOURNAL OF CELL BIOLOGY

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

(2019) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

(2019) Stine Lauritzen Sønder et al.   Scientific Reports

Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly

(2019) Sudeep Banjade et al.   eLife

ESCRT-mediated phagophore sealing during mitophagy

(2019) Yan Zhen et al.   Autophagy

VPS37A directs ESCRT recruitment for phagophore closure

(2019) Yoshinori Takahashi et al.   JOURNAL OF CELL BIOLOGY

Ubiquitin recognition in endocytic trafficking – with or without ESCRT-0

(2019) Niccolò Mosesso et al.   JOURNAL OF CELL SCIENCE

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

(2019) John J. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

(2019) Jingyue Jia et al.   DEVELOPMENTAL CELL

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Plasma membrane repair

(2018) Norma W. Andrews et al.   CURRENT BIOLOGY

The Dynamic Nature of the Nuclear Envelope

(2018) Paola De Magistris et al.   CURRENT BIOLOGY

ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum

(2018) Fred D. Mast et al.   JOURNAL OF CELL BIOLOGY

Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair

(2018) Lauren Penfield et al.   MOLECULAR BIOLOGY OF THE CELL

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

(2018) Yoshinori Takahashi et al.   Nature Communications

Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes

(2018) John McCullough et al.   Annual Review of Cell and Developmental Biology

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

(2018) Leandro N. Ventimiglia et al.   DEVELOPMENTAL CELL

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4

(2018) Johannes Schöneberg et al.   SCIENCE

ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

(2018) Sebastian Rühl et al.   SCIENCE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

(2017) Mingyu Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

(2016) Changqian Zhou et al.   CELL RESEARCH

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation

(2016) Yolanda Olmos et al.   CURRENT BIOLOGY

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity

(2016) Nicholas A. Bright et al.   CURRENT BIOLOGY

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission

(2016) Manuel Alonso Y Adell et al.   FEBS Journal

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein

(2016) Brian J. McMillan et al.   Cell Reports

Autophagosome closure requires membrane scission

(2015) Roland L Knorr et al.   Autophagy

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

ESCRTs are everywhere

(2015) J. H. Hurley   EMBO JOURNAL

ESCRT-III controls nuclear envelope reformation

(2015) Yolanda Olmos et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane Repair: Mechanisms and Pathophysiology

(2015) Sandra T. Cooper et al.   PHYSIOLOGICAL REVIEWS

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation

(2015) Bei Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments

(2015) Shaogeng Tang et al.   eLife

Surveillance of Nuclear Pore Complex Assembly by ESCRT-III/Vps4

(2014) Brant M. Webster et al.   CELL

A Unique Plant ESCRT Component, FREE1, Regulates Multivesicular Body Protein Sorting and Plant Growth

(2014) Caiji Gao et al.   CURRENT BIOLOGY

Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation

(2014) Manuel Alonso Y Adell et al.   JOURNAL OF CELL BIOLOGY

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Damage control: cellular mechanisms of plasma membrane repair

(2014) Norma W. Andrews et al.   TRENDS IN CELL BIOLOGY

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Membrane Fission Reactions of the Mammalian ESCRT Pathway

(2013) John McCullough et al.   Annual Review of Biochemistry

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

An ESCRT–spastin interaction promotes fission of recycling tubules from the endosome

(2013) Rachel Allison et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanisms of the Membrane Sculpting ESCRT Pathway

(2013) W. M. Henne et al.   Cold Spring Harbor Perspectives in Biology

HIV-1 Assembly, Budding, and Maturation

(2013) W. I. Sundquist et al.   Cold Spring Harbor Perspectives in Medicine

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

ESCRT-III Protein Requirements for HIV-1 Budding

(2011) Eiji Morita et al.   Cell Host & Microbe

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Structural basis for ESCRT-III protein autoinhibition

(2009) Monika Bajorek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Computational Model of Membrane Fission Catalyzed by ESCRT-III

(2009) Gur Fabrikant et al.   PLoS Computational Biology

The life cycle of the metazoan nuclear envelope

(2008) Daniel J Anderson et al.   CURRENT OPINION IN CELL BIOLOGY

Ordered Assembly of the ESCRT-III Complex on Endosomes Is Required to Sequester Cargo during MVB Formation

(2008) David Teis et al.   DEVELOPMENTAL CELL

Structural Basis for Autoinhibition of ESCRT-III CHMP3

(2008) Suman Lata et al.   JOURNAL OF MOLECULAR BIOLOGY

A Role for the ESCRT System in Cell Division in Archaea

(2008) R. Y. Samson et al.   SCIENCE