Repair of nuclear ruptures requires barrier-to-autointegration factor

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

(2019) Matteo Gentili et al.   Cell Reports

Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair

(2018) Lauren Penfield et al.   MOLECULAR BIOLOGY OF THE CELL

Automated analysis of cell migration and nuclear envelope rupture in confined environments

(2018) Joshua J. Elacqua et al.   PLoS One

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

(2018) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases

(2018) Camille Samson et al.   NUCLEIC ACIDS RESEARCH

Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures

(2018) Natalie Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local, transient tensile stress on the nuclear membrane causes membrane rupture

(2018) Qiao Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Elastic modulus and hydraulic permeability of MDCK monolayers

(2017) K.D. Schulze et al.   JOURNAL OF BIOMECHANICS

VRK2A is an A-type lamin–dependent nuclear envelope kinase that phosphorylates BAF

(2017) Birendra KC et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb

(2017) Zhe Yang et al.   MOLECULAR CANCER RESEARCH

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

(2017) Mingyu Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Presumed pseudokinase VRK3 functions as a BAF kinase

(2015) Choon-Ho Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments

(2015) Patricia M. Davidson et al.   Integrative Biology

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell

(2015) Srujana Neelam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation

(2014) Nicolas Paquet et al.   BMC MOLECULAR BIOLOGY

Nuclear Deformability Constitutes a Rate-Limiting Step During Cell Migration in 3-D Environments

(2014) Patricia M. Davidson et al.   Cellular and Molecular Bioengineering

Cell- and Virus-Mediated Regulation of the Barrier-to-Autointegration Factor's Phosphorylation State Controls Its DNA Binding, Dimerization, Subcellular Localization, and Antipoxviral Activity

(2014) A. Jamin et al.   JOURNAL OF VIROLOGY

Depletion of the protein kinase VRK1 disrupts nuclear envelope morphology and leads to BAF retention on mitotic chromosomes

(2014) Tyler P. Molitor et al.   MOLECULAR BIOLOGY OF THE CELL

Barrier to Autointegration Factor Becomes Dephosphorylated during HSV-1 Infection and Can Act as a Host Defense by Impairing Viral DNA Replication and Gene Expression

(2014) Augusta Jamin et al.   PLoS One

Dephosphorylation of Barrier-to-autointegration Factor by Protein Phosphatase 4 and Its Role in Cell Mitosis

(2013) Xiaolei Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase

(2013) Nouhou Ibrahim et al.   VIROLOGY

Coordination of Kinase and Phosphatase Activities by Lem4 Enables Nuclear Envelope Reassembly during Mitosis

(2012) Claudio Asencio et al.   CELL

Familial partial lipodystrophy, mandibuloacral dysplasia and restrictive dermopathy feature barrier-to-autointegration factor (BAF) nuclear redistribution

(2012) Cristina Capanni et al.   CELL CYCLE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Exome Sequencing and Functional Analysis Identifies BANF1 Mutation as the Cause of a Hereditary Progeroid Syndrome

(2011) Xose S. Puente et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Néstor-Guillermo progeria syndrome: A novel premature aging condition with early onset and chronic development caused by BANF1 mutations

(2011) Rubén Cabanillas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Molecular Characterization of the Host Defense Activity of the Barrier to Autointegration Factor against Vaccinia Virus

(2011) N. Ibrahim et al.   JOURNAL OF VIROLOGY

No Interaction of Barrier-to-Autointegration Factor (BAF) with HIV-1 MA, Cone-Rod Homeobox (Crx) or MAN1-C in Absence of DNA

(2011) Ying Huang et al.   PLoS One

Genetic and ultrastructural studies in dilated cardiomyopathy patients: a large deletion in the lamin A/C gene is associated with cardiomyocyte nuclear envelope disruption

(2010) Pallavi Gupta et al.   BASIC RESEARCH IN CARDIOLOGY

Lamin A precursor induces barrier-to-autointegration factor nuclear localization

(2010) Cristina Capanni et al.   CELL CYCLE

Barrier-to-Autointegration Factor Proteome Reveals Chromatin-Regulatory Partners

(2009) Rocío Montes de Oca et al.   PLoS One