Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins

(2020) Alexandra M. Young et al.   MOLECULAR BIOLOGY OF THE CELL

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation

(2020) Alexander von Appen et al.   NATURE

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

(2019) David J Thaller et al.   eLife

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

(2019) Jessica Willan et al.   Oncogenesis

On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update

(2019) Alla S. Koltsova et al.   Frontiers in Genetics

Repair of nuclear ruptures requires barrier-to-autointegration factor

(2019) Charles T. Halfmann et al.   JOURNAL OF CELL BIOLOGY

The ESCRT-machinery: closing holes and expanding roles

(2019) Alberto T Gatta et al.   CURRENT OPINION IN CELL BIOLOGY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity

(2018) Jun Arii et al.   Nature Communications

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

(2018) Leandro N. Ventimiglia et al.   DEVELOPMENTAL CELL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

(2017) Beata E. Mierzwa et al.   NATURE CELL BIOLOGY

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

(2017) Mingyu Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis

(2017) Peter Ly et al.   TRENDS IN CELL BIOLOGY

Measurement of Rapid Protein Diffusion in the Cytoplasm by Photo-Converted Intensity Profile Expansion

(2017) Rotem Gura Sadovsky et al.   Cell Reports

Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology

(2017) Sumit Pawar et al.   eLife

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

(2017) Ho Yee Joyce Fung et al.   eLife

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation

(2016) Yolanda Olmos et al.   CURRENT BIOLOGY

Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing

(2016) Brant M Webster et al.   EMBO JOURNAL

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

(2015) Mitchell L. Leibowitz et al.   Annual Review of Genetics

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation

(2015) Nicolas Chiaruttini et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

Establishment of NE asymmetry—targeting of membrane proteins to the inner nuclear membrane

(2015) Rosemarie Ungricht et al.   CURRENT OPINION IN CELL BIOLOGY

Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane

(2015) Rosemarie Ungricht et al.   JOURNAL OF CELL BIOLOGY

ESCRT-III controls nuclear envelope reformation

(2015) Yolanda Olmos et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Structure and membrane remodeling activity of ESCRT-III helical polymers

(2015) J. McCullough et al.   SCIENCE

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

(2015) Koray Kırlı et al.   eLife

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Diffusion Coefficients of Endogenous Cytosolic Proteins from Rabbit Skinned Muscle Fibers

(2014) Brian E. Carlson et al.   BIOPHYSICAL JOURNAL

Surveillance of Nuclear Pore Complex Assembly by ESCRT-III/Vps4

(2014) Brant M. Webster et al.   CELL

Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation

(2014) Manuel Alonso Y Adell et al.   JOURNAL OF CELL BIOLOGY

A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

(2014) Jacek R. Wiśniewski et al.   MOLECULAR & CELLULAR PROTEOMICS

Association of CHMP4B and Autophagy with Micronuclei: Implications for Cataract Formation

(2014) Antonia P. Sagona et al.   Biomed Research International

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Coordination of Kinase and Phosphatase Activities by Lem4 Enables Nuclear Envelope Reassembly during Mitosis

(2012) Claudio Asencio et al.   CELL

Comparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins

(2012) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Deep proteome and transcriptome mapping of a human cancer cell line

(2011) N. Nagaraj et al.   Molecular Systems Biology

The quantitative proteome of a human cell line

(2011) M. Beck et al.   Molecular Systems Biology

Protein Diffusion in Mammalian Cell Cytoplasm

(2011) Thomas Kühn et al.   PLoS One

Single Molecule Diffusion of Membrane-Bound Proteins: Window into Lipid Contacts and Bilayer Dynamics

(2010) Jefferson D. Knight et al.   BIOPHYSICAL JOURNAL

Torsional regulation of hRPA-induced unwinding of double-stranded DNA

(2010) Iwijn De Vlaminck et al.   NUCLEIC ACIDS RESEARCH

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS