Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration

(2021) Taylor J. Fiolek et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers

(2021) Taylor J. Fiolek et al.   ACS Chemical Neuroscience

Specific Degradation of Endogenous Tau Protein and Inhibition of Tau Fibrillation by Tanshinone IIA through the Ubiquitin–Proteasome Pathway

(2020) Nan Cai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New Peptide-Based Pharmacophore Activates 20S Proteasome

(2020) Paweł A. Osmulski et al.   MOLECULES

Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster

(2019) Nga N. Nguyen et al.   Scientific Reports

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

(2019) Erin Munkácsy et al.   AGING CELL

Small Molecule Modulation of Proteasome Assembly

(2018) Evert Njomen et al.   BIOCHEMISTRY

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

(2018) Małgorzata Giżyńska et al.   JOURNAL OF MEDICINAL CHEMISTRY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Therapeutic applications of the cell-penetrating HIV-1 Tat peptide

(2015) Mafalda Rizzuti et al.   DRUG DISCOVERY TODAY

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway

(2015) Jin Chu et al.   JOURNAL OF NEUROCHEMISTRY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein

(2015) Przemysław Karpowicz et al.   PLoS One

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

(2015) Sofie Stalmans et al.   PLoS One

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster

(2014) Siddhita D. Mhatre et al.   EXPERIMENTAL NEUROLOGY

Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity

(2014) Ashok N. Hegde et al.   Frontiers in Molecular Neuroscience

Targeting the ubiquitin proteasome system in haematological malignancies

(2013) Lisa J. Crawford et al.   BLOOD REVIEWS

Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

(2013) Amanda L. Wright et al.   PLoS One

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

(2012) Hwan-Ching Tai et al.   AMERICAN JOURNAL OF PATHOLOGY

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of a Drosophila Alzheimer's Disease Model: Pharmacological Rescue of Cognitive Defects

(2011) Ranjita Chakraborty et al.   PLoS One

Postnatal Proteasome Inhibition Induces Neurodegeneration and Cognitive Deficiencies in Adult Mice: A New Model of Neurodevelopment Syndrome

(2011) Rocío Romero-Granados et al.   PLoS One

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential allosteric modulators of the proteasome activity

(2010) E. Jankowska et al.   BIOPOLYMERS

Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation

(2010) F. Cai et al.   NEUROSCIENCE

The ubiquitin proteasome system and its involvement in cell death pathways

(2009) F Bernassola et al.   CELL DEATH AND DIFFERENTIATION

In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid β-peptide of APP

(2009) D. Allan Butterfield et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function

(2009) Kenneth M. Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The proteasome: Overview of structure and functions

(2009) Keiji TANAKA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity

(2008) Chunli Ren et al.   EXPERIMENTAL GERONTOLOGY

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE

Aβ inhibits the proteasome and enhances amyloid and tau accumulation

(2007) Bertrand P. Tseng et al.   NEUROBIOLOGY OF AGING