New Peptide-Based Pharmacophore Activates 20S Proteasome

Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders

(2019) Evert Njomen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline

(2019) Erin Munkácsy et al.   AGING CELL

Methods to Discover and Evaluate Proteasome Small Molecule Stimulators

(2019) Rachel A. Coleman et al.   MOLECULES

Proteasome Activation to Combat Proteotoxicity

(2019) Corey L. Jones et al.   MOLECULES

Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes

(2019) Ana Toste Rêgo et al.   MOLECULAR CELL

Small Molecule Modulation of Proteasome Assembly

(2018) Evert Njomen et al.   BIOCHEMISTRY

Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators

(2018) Rachel A. Coleman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

(2018) Małgorzata Giżyńska et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins

(2018) Sneh Lata et al.   Frontiers in Microbiology

Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome – insights into the enzyme activation mechanism

(2017) Julia Witkowska et al.   Scientific Reports

Structural basis for dynamic regulation of the human 26S proteasome

(2016) Shuobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inhibition mechanism of human 20Sproteasomes enables next-generation inhibitor design

(2016) Jil Schrader et al.   SCIENCE

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein

(2015) Przemysław Karpowicz et al.   PLoS One

A molecular census of 26S proteasomes in intact neurons

(2015) S. Asano et al.   SCIENCE

Harnessing Proteasome Dynamics and Allostery in Drug Design

(2014) Maria Gaczynska et al.   ANTIOXIDANTS & REDOX SIGNALING

Protein-Protein Docking: From Interaction to Interactome

(2014) Ilya A. Vakser   BIOPHYSICAL JOURNAL

Dissecting a role of a charge and conformation of Tat2 peptide in allosteric regulation of 20S proteasome

(2014) Julia Witkowska et al.   JOURNAL OF PEPTIDE SCIENCE

The proteasome: molecular machinery and pathophysiological roles

(2012) Keiji Tanaka et al.   BIOLOGICAL CHEMISTRY

Potential allosteric modulators of the proteasome activity

(2010) E. Jankowska et al.   BIOPOLYMERS

Simultaneous Fluorescent Monitoring of Proteasomal Subunit Catalysis

(2010) Aya Wakata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms of proteasome plasticity in aging

(2010) Karl A. Rodriguez et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel

(2009) Pawel A. Osmulski et al.   STRUCTURE

Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

(2008) L. Bedford et al.   JOURNAL OF NEUROSCIENCE