Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein

Oligomers and peptidomimetics consisting of methyl 3-amino-2,3-dideoxyhexopyranosiduronic acids

(2015) Emilia Sikorska et al.   TETRAHEDRON

Harnessing Proteasome Dynamics and Allostery in Drug Design

(2014) Maria Gaczynska et al.   ANTIOXIDANTS & REDOX SIGNALING

Dissecting a role of a charge and conformation of Tat2 peptide in allosteric regulation of 20S proteasome

(2014) Julia Witkowska et al.   JOURNAL OF PEPTIDE SCIENCE

Carfilzomib

(2013) K. M. Kortuem et al.   BLOOD

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Inhibition of the Human Proteasome by Imidazoline Scaffolds

(2013) Lauren M. Azevedo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Noncompetitive Modulation of the Proteasome by Imidazoline Scaffolds Overcomes Bortezomib Resistance and Delays MM Tumor Growth in Vivo

(2012) Theresa A. Lansdell et al.   ACS Chemical Biology

Diversity of Allosteric Regulation in Proteases

(2012) Melisa Merdanovic et al.   ACS Chemical Biology

Conformational Preferences of Proline Derivatives Incorporated into Vasopressin Analogues: NMR and Molecular Modelling Studies

(2012) Emilia Sikorska et al.   Chemical Biology & Drug Design

Proteasome allostery as a population shift between interchanging conformers

(2012) A. M. Ruschak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery

(2011) Bruce J. Melancon et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Proteasome Activators

(2011) Beth M. Stadtmueller et al.   MOLECULAR CELL

Potential allosteric modulators of the proteasome activity

(2010) E. Jankowska et al.   BIOPOLYMERS

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

Effect of Noncompetitive Proteasome Inhibition on Bortezomib Resistance

(2010) Xiaoming Li et al.   JNCI-Journal of the National Cancer Institute

Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

(2010) Kianoush Sadre-Bazzaz et al.   MOLECULAR CELL

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

A Tetrahedral Transition State at the Active Sites of the 20S Proteasome Is Coupled to Opening of the α-Ring Channel

(2009) Pawel A. Osmulski et al.   STRUCTURE

TROSY-Based NMR Evidence for a Novel Class of 20S Proteasome Inhibitors†

(2008) Remco Sprangers et al.   BIOCHEMISTRY

Novel fluorinated pseudopeptides as proteasome inhibitors

(2008) Lucia Formicola et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities

(2008) Alexander Kloß et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma

(2008) X Mao et al.   LEUKEMIA

Radius of gyration as an indicator of protein structure compactness

(2008) M. Yu. Lobanov et al.   MOLECULAR BIOLOGY