Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration

Fluorescent Probes with Unnatural Amino Acids to Monitor Proteasome Activity in Real-Time

(2020) Breanna L Zerfas et al.   ACS Chemical Biology

Proteasome Activation as a New Therapeutic Approach To Target Proteotoxic Disorders

(2019) Evert Njomen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methods to Discover and Evaluate Proteasome Small Molecule Stimulators

(2019) Rachel A. Coleman et al.   MOLECULES

The Contribution of the 20S Proteasome to Proteostasis

(2019) Fanindra Kumar Deshmukh et al.   Biomolecules

Small Molecule Modulation of Proteasome Assembly

(2018) Evert Njomen et al.   BIOCHEMISTRY

Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration

(2018) Kwadwo A. Opoku-Nsiah et al.   Translational Research

Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators

(2018) Rachel A. Coleman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Proteasome Structure and Assembly

(2017) Lauren Budenholzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Drugging Undruggable Molecular Cancer Targets

(2016) John S. Lazo et al.   Annual Review of Pharmacology and Toxicology

Untapped Potential of Disordered Proteins in Current Druggable Human Proteome

(2016) Gang Hu et al.   CURRENT DRUG TARGETS

Order, Disorder, and Everything in Between

(2016) Shelly DeForte et al.   MOLECULES

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

Regulation and aggregation of intrinsically disordered peptides

(2015) Zachary A. Levine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis

(2014) Paul C. Trippier et al.   ACS Chemical Neuroscience

Enhanced proteasome degradation extends Caenorhabditis elegans lifespan and alleviates aggregation-related pathologies

(2014) Niki Chondrogianni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteasome activation delays aging in vitro and in vivo

(2014) Niki Chondrogianni et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Synuclein Misfolding Versus Aggregation Relevance to Parkinson’s Disease: Critical Assessment and Modeling

(2014) Ruben Berrocal et al.   MOLECULAR NEUROBIOLOGY

Neurodegenerative disease: Brain windfall

(2014) Katharine Gammon   NATURE

The proteasome and the degradation of oxidized proteins: Part III—Redox regulation of the proteasomal system

(2014) Tobias Jung et al.   Redox Biology

Ubiquitin-independent proteasomal degradation

(2013) Jenny Erales et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of the Human Proteasome by Imidazoline Scaffolds

(2013) Lauren M. Azevedo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

(2013) Tobias Jung et al.   Redox Biology

Noncompetitive Modulation of the Proteasome by Imidazoline Scaffolds Overcomes Bortezomib Resistance and Delays MM Tumor Growth in Vivo

(2012) Theresa A. Lansdell et al.   ACS Chemical Biology

The proteasome: molecular machinery and pathophysiological roles

(2012) Keiji Tanaka et al.   BIOLOGICAL CHEMISTRY

Intrinsically disordered proteins: regulation and disease

(2011) M Madan Babu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

Structural–activity relationship study of highly-functionalized imidazolines as potent inhibitors of nuclear transcription factor-κB mediated IL-6 production

(2009) Daljinder K. Kahlon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein disorder in the human diseasome: unfoldomics of human genetic diseases

(2009) Uros Midic et al.   BMC GENOMICS

Unfoldomics of human diseases: linking protein intrinsic disorder with diseases

(2009) Vladimir N Uversky et al.   BMC GENOMICS

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

α-Synuclein Misfolding and Neurodegenerative Diseases

(2008) Vladimir Uversky   CURRENT PROTEIN & PEPTIDE SCIENCE