Reprogramming neurons for regeneration: The fountain of youth

CRISPR technologies for precise epigenome editing

(2021) Muneaki Nakamura et al.   NATURE CELL BIOLOGY

Engineering 3D genome organization

(2021) Haifeng Wang et al.   NATURE REVIEWS GENETICS

Direct cell reprogramming: approaches, mechanisms and progress

(2021) Haofei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Promotion of corticospinal tract growth by KLF6 requires an injury stimulus and occurs within four weeks of treatment

(2021) Audra A. Kramer et al.   EXPERIMENTAL NEUROLOGY

An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping

(2021) Shun Hamada et al.   Communications Biology

Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming

(2021) Hao Qian et al.   Annual Review of Genetics

Single-cell analysis enters the multiomics age

(2021) Jeffrey M. Perkel   NATURE

The cell as a bag of RNA

(2021) Stephen R. Quake   TRENDS IN GENETICS

Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2

(2021) J. Kempf et al.   Cell Reports

The Evolution of the Hallmarks of Aging

(2021) Maël Lemoine   Frontiers in Genetics

Convergence Circuit Mapping: Genetic Approaches From Structure to Function

(2021) Jang Soo Yook et al.   Frontiers in Systems Neuroscience

AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset

(2021) David Goertsen et al.   NATURE NEUROSCIENCE

Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

(2021) Riccardo Bocchi et al.   NEURON

Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH

(2020) Su-Hyuk Ko et al.   Autophagy

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

The ageing epigenome and its rejuvenation

(2020) Weiqi Zhang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective targeting of TET catalytic domain promotes somatic cell reprogramming

(2020) Anup Kumar Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors

(2020) Dan Wang et al.   CELL

Mouse γ-Synuclein Promoter-Mediated Gene Expression and Editing in Mammalian Retinal Ganglion Cells

(2020) Qizhao Wang et al.   JOURNAL OF NEUROSCIENCE

Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury

(2020) Fatima M. Nathan et al.   MOLECULAR THERAPY

Injured adult neurons regress to an embryonic transcriptional growth state

(2020) Gunnar H. D. Poplawski et al.   NATURE

Strategies to Promote Long-Distance Optic Nerve Regeneration

(2020) Shu-Guang Yang et al.   Frontiers in Cellular Neuroscience

Updates and challenges of axon regeneration in the mammalian central nervous system

(2020) Cheng Qian et al.   Journal of Molecular Cell Biology

Single-cell multiomics: technologies and data analysis methods

(2020) Jeongwoo Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

In vivo glial trans‐differentiation for neuronal replacement and functional recovery in central nervous system

(2020) Cheng Qian et al.   FEBS Journal

Reprogramming to recover youthful epigenetic information and restore vision

(2020) Yuancheng Lu et al.   NATURE

Chemical and optical control of CRISPR-associated nucleases

(2020) Ashley E. Modell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Lin28 is a critical factor in the function and aging of Drosophila testis stem cell niche

(2019) Perinthottathil Sreejith et al.   Aging-US

Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc

(2019) Jin-Jin Ma et al.   JOURNAL OF NEUROSCIENCE

Targeting oncogenic SOX2 in human cancer cells: therapeutic application

(2019) Shizhen Zhang et al.   Protein & Cell

Small molecule-induced cellular fate reprogramming: promising road leading to Rome

(2018) Xiang Li et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Increased Expression of Transcription Factor SRY-box-Containing Gene 11 (Sox11) Enhances Neurite Growth by Regulating Neurotrophic Factor Responsiveness

(2018) Michael P. Jankowski et al.   NEUROSCIENCE

MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state

(2018) Vittoria Poli et al.   Nature Communications

let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration

(2018) Simran Kaur et al.   Cell Reports

Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

(2018) Kai Yao et al.   NATURE

Transdifferentiation: a new promise for neurodegenerative diseases

(2018) Cristiana Mollinari et al.   Cell Death & Disease

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons

(2018) Zimei Wang et al.   Scientific Reports

LIN28A activates the transcription of NANOG in dairy goat male germline stem cells

(2018) Fanglin Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Promoting Axon Regeneration in Adult CNS by Targeting Liver Kinase B1

(2018) Yosuke Ohtake et al.   MOLECULAR THERAPY

Different Effect of Sox11 in Retinal Ganglion Cells Survival and Axon Regeneration

(2018) Ying Li et al.   Frontiers in Genetics

Regulation of reproduction and longevity by nutrient-sensing pathways

(2017) Nicole M. Templeman et al.   JOURNAL OF CELL BIOLOGY

Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

(2017) Ramona E. von Leden et al.   Journal of Neuroinflammation

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS

(2017) Akintomide Apara et al.   JOURNAL OF NEUROSCIENCE

Stimulation of functional neuronal regeneration from Müller glia in adult mice

(2017) Nikolas L. Jorstad et al.   NATURE

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury

(2017) Zimei Wang et al.   NEUROBIOLOGY OF DISEASE

RNA editing with CRISPR-Cas13

(2017) David B. T. Cox et al.   SCIENCE

A Lin28 homologue reprograms differentiated cells to stem cells in the moss Physcomitrella patens

(2017) Chen Li et al.   Nature Communications

LIN-28 balances longevity and germline stem cell number inCaenorhabditis elegansthrough let-7/AKT/DAF-16 axis

(2016) Dan Wang et al.   AGING CELL

RNA-binding protein Lin28 in cancer and immunity

(2016) Shuai Jiang et al.   CANCER LETTERS

Communication in Neural Circuits: Tools, Opportunities, and Challenges

(2016) Talia N. Lerner et al.   CELL

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

(2016) Jin Zhang et al.   Cell Stem Cell

Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord

(2016) N. Jayaprakash et al.   JOURNAL OF NEUROSCIENCE

Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression

(2016) Yaxue Zeng et al.   MOLECULAR CELL

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

(2016) Vijayendran Chandran et al.   NEURON

Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury

(2016) Miao He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lin28 and let-7 in the Metabolic Physiology of Aging

(2016) Elwin Tan Jun-Hao et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration

(2016) Zhaoxia Mu et al.   Neuroscience Bulletin

Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation

(2016) Elsa Vera et al.   Cell Reports

GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

(2016) Xinzheng Guo et al.   eLife

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

(2016) Linqing Miao et al.   eLife

Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus

(2015) Ana Maria Marques Orellana et al.   Aging-US

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency

(2015) Lorenz Studer et al.   Cell Stem Cell

Growth hormone, insulin-like growth factor-1 and the aging brain

(2015) Nicole M. Ashpole et al.   EXPERIMENTAL GERONTOLOGY

Overexpression of Sox11 Promotes Corticospinal Tract Regeneration after Spinal Injury While Interfering with Functional Recovery

(2015) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Axonal transport declines with age in two distinct phases separated by a period of relative stability

(2015) Stefan Milde et al.   NEUROBIOLOGY OF AGING

Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics

(2015) Stephane Belin et al.   NEURON

Myc mouse and anti-ageing therapy

(2015) Nazif Alic et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression

(2015) J-J Jiang et al.   Cell Death & Disease

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

NANOG Amplifies STAT3 Activation and They Synergistically Induce the Naive Pluripotent Program

(2014) Hannah T. Stuart et al.   CURRENT BIOLOGY

Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration

(2014) Alexandra B. Byrne et al.   NEURON

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

(2013) Ng Shyh-Chang et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming

(2013) Yawei Gao et al.   Cell Stem Cell

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration

(2013) C.-M. Liu et al.   GENES & DEVELOPMENT

Transcription Factors SOX4 and SOX11 Function Redundantly to Regulate the Development of Mouse Retinal Ganglion Cells

(2013) Ying Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

(2013) Matthew H Larson et al.   Nature Protocols

Myc-Dependent Genome Instability and Lifespan in Drosophila

(2013) Christina Greer et al.   PLoS One

Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers

(2013) Y. Zou et al.   SCIENCE

Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds

(2013) P. Hou et al.   SCIENCE

PI3K–GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1

(2013) Saijilafu et al.   Nature Communications

Cross-talk between KLF4 and STAT3 regulates axon regeneration

(2013) Song Qin et al.   Nature Communications

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

(2013) Meng-Lu Liu et al.   Nature Communications

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b

(2012) C. Powell et al.   JOURNAL OF NEUROSCIENCE

SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

(2012) L. Mu et al.   JOURNAL OF NEUROSCIENCE

Cis-regulatory control of corticospinal system development and evolution

(2012) Sungbo Shim et al.   NATURE

TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11

(2012) K.M. Salerno et al.   NEUROSCIENCE

Kruppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract

(2012) M. G. Blackmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation

(2012) Yong Tang et al.   STEM CELLS

The transcription factor Sox11 promotes nerve regeneration through activation of the regeneration-associated gene Sprr1a

(2011) Xiaotang Jing et al.   EXPERIMENTAL NEUROLOGY

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

(2011) Tian-Peng Gu et al.   NATURE

Slowing of axonal regeneration is correlated with increased axonal viscosity during aging

(2010) Phillip L Lamoureux et al.   BMC NEUROSCIENCE

Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues

(2010) Marcella Fulco et al.   CELL CYCLE

Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency

(2010) Jian Yang et al.   Cell Stem Cell

Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system

(2010) M. R. Potzner et al.   DEVELOPMENT

Sox11 regulates survival and axonal growth of embryonic sensory neurons

(2010) L. Lin et al.   DEVELOPMENTAL DYNAMICS

Ascl1a regulates Müller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway

(2010) Rajesh Ramachandran et al.   NATURE CELL BIOLOGY

Mammalian Krüppel-Like Factors in Health and Diseases

(2010) Beth B. McConnell et al.   PHYSIOLOGICAL REVIEWS

Promotion of direct reprogramming by transformation-deficient Myc

(2010) M. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

(2009) D. L. Moore et al.   SCIENCE

Sox11 transcription factor modulates peripheral nerve regeneration in adult mice

(2008) Michael P. Jankowski et al.   BRAIN RESEARCH

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse

(2008) Matthias Stadtfeld et al.   Cell Stem Cell

c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts

(2008) Marius Wernig et al.   Cell Stem Cell

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE