Reprogramming to recover youthful epigenetic information and restore vision

Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting

(2020) Hongjie Li et al.   CURRENT BIOLOGY

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

(2020) Tapash Jay Sarkar et al.   Nature Communications

Ribosomal DNA harbors an evolutionarily conserved clock of biological aging

(2019) Meng Wang et al.   GENOME RESEARCH

Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs

(2019) Yiling Zhang et al.   NEURON

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

(2019) Anitha Krishnan et al.   Journal of Neuroinflammation

AAV vector-mediated in vivo reprogramming into pluripotency

(2018) Elena Senís et al.   Nature Communications

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition

(2018) Tim A. Rand et al.   Cell Reports

Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

(2018) Steve Horvath et al.   Aging-US

Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

(2018) Kai Yao et al.   NATURE

Restoring vision

(2018) Botond Roska et al.   NATURE

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

(2018) Nelly Olova et al.   AGING CELL

A multi-tissue full lifespan epigenetic clock for mice

(2018) Michael J. Thompson et al.   Aging-US

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Decoding the role of TET family dioxygenases in lineage specification

(2018) Xinwei Wu et al.   Epigenetics & Chromatin

A whole lifespan mouse multi-tissue DNA methylation clock

(2018) Margarita V Meer et al.   eLife

Neuroprotection for glaucoma: Requirements for clinical translation

(2017) Leonard A. Levin et al.   EXPERIMENTAL EYE RESEARCH

Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries

(2017) Daniel Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conserved effect of aging on DNA methylation and association with EZH2 polycomb protein in mice and humans

(2017) Khyobeni Mozhui et al.   MECHANISMS OF AGEING AND DEVELOPMENT

TET-mediated active DNA demethylation: mechanism, function and beyond

(2017) Xiaoji Wu et al.   NATURE REVIEWS GENETICS

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

(2017) Yi-Lan Weng et al.   NEURON

Regenerating optic pathways from the eye to the brain

(2017) Bireswar Laha et al.   SCIENCE

Epigenetic Mechanisms of Longevity and Aging

(2016) Payel Sen et al.   CELL

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma

(2016) Anitha Krishnan et al.   JOURNAL OF IMMUNOLOGY

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System

(2016) Xueting Luo et al.   Cell Reports

Evidence for an Age-Dependent Decline in Axon Regeneration in the Adult Mammalian Central Nervous System

(2016) Cédric G. Geoffroy et al.   Cell Reports

The cerebellum ages slowly according to the epigenetic clock

(2015) Steve Horvath et al.   Aging-US

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Changes in Regenerative Capacity through Lifespan

(2015) Maximina Yun   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair

(2015) Huimei Yu et al.   NATURE NEUROSCIENCE

Exome Sequencing Identifies a Missense Variant in EFEMP1 Co-Segregating in a Family with Autosomal Dominant Primary Open-Angle Glaucoma

(2015) Donna S. Mackay et al.   PLoS One

Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice

(2014) Andrew J. McClellan et al.   AMERICAN JOURNAL OF PATHOLOGY

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

(2014) Kotaro Ohnishi et al.   CELL

Small molecules facilitate rapid and synchronous iPSC generation

(2014) Ori Bar-Nur et al.   NATURE METHODS

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Replacement of Oct4 by Tet1 during iPSC Induction Reveals an Important Role of DNA Methylation and Hydroxymethylation in Reprogramming

(2013) Yawei Gao et al.   Cell Stem Cell

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

Low-level processing of Illumina Infinium DNA Methylation BeadArrays

(2013) Timothy J. Triche et al.   NUCLEIC ACIDS RESEARCH

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells

(2013) Francesco Neri et al.   GENOME BIOLOGY

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

(2011) Kian Peng Koh et al.   Cell Stem Cell

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

(2009) D. L. Moore et al.   SCIENCE

AmiGO: online access to ontology and annotation data

(2008) Seth Carbon et al.   BIOINFORMATICS

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE