标题
ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain
作者
关键词
-
出版物
PHARMACOLOGICAL REVIEWS
Volume 74, Issue 3, Pages 797-822
出版商
American Society for Pharmacology & Experimental Therapeutics (ASPET)
发表日期
2022-06-23
DOI
10.1124/pharmrev.121.000528
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structure–Activity Relationship of 3-Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors
- (2022) Mirko Scortichini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tumors resurrect an embryonic vascular program to escape immunity
- (2022) Elisabeth J. M. Huijbers et al. Science Immunology
- SAR442085, a novel anti-CD38 antibody with enhanced antitumor activity against multiple myeloma
- (2022) Sahar Kassem et al. BLOOD
- CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity
- (2022) Karolina Losenkova et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- International Union of Basic and Clinical Pharmacology. CXII: Adenosine Receptors: A Further Update
- (2022) Adriaan P. IJzerman et al. PHARMACOLOGICAL REVIEWS
- Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis
- (2022) Shuai Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors
- (2021) Ehesan U. Sharif et al. JOURNAL OF MEDICINAL CHEMISTRY
- Loss of CD73 shifts transforming growth factor-β1 (TGF-β1) from tumor suppressor to promoter in endometrial cancer
- (2021) Katherine C. Kurnit et al. CANCER LETTERS
- Adenylate kinase 2 expression and addiction in T-ALL
- (2021) Nabih Maslah et al. Blood Advances
- Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion
- (2021) Michael N. Sayegh et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Targeting adenosine with adenosine deaminase 2 to inhibit growth of solid tumors
- (2021) Lin Wang et al. CANCER RESEARCH
- Enzymology of extracellular NAD metabolism
- (2021) Massimiliano Gasparrini et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance
- (2021) Catalina Lodillinsky et al. ONCOGENE
- High Throughput Multi-Omics Approaches for Clinical Trial Evaluation and Drug Discovery
- (2021) Jessica M. Zielinski et al. Frontiers in Immunology
- High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer
- (2021) Yacine Bareche et al. Journal for ImmunoTherapy of Cancer
- Developmental role of adenosine kinase in the cerebellum
- (2021) Hoda Gebril et al. eNeuro
- Functional genomics approaches to improve pre‐clinical drug screening and biomarker discovery
- (2021) Long V Nguyen et al. EMBO Molecular Medicine
- Epitranscriptomics modifier Pentostatin indirectly triggers Toll-like Receptor 3 and can enhance immune infiltration in tumours
- (2021) Marina Tusup et al. MOLECULAR THERAPY
- Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
- (2021) María Casanova-Acebes et al. NATURE
- SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling
- (2021) Jiangyi Wang et al. Cell Death & Disease
- Divergent synthesis and elaboration of structure activity relationship for quinoline derivatives as highly selective NTPDase inhibitor
- (2021) Amna Murtaza et al. BIOORGANIC CHEMISTRY
- Prognostic significance of NT5E/CD73 in neuroblastoma and its function in CSC stemness maintenance
- (2021) Drishti Jain et al. CELL BIOLOGY AND TOXICOLOGY
- A hormone complex of FABP4 and nucleoside kinases regulates islet function
- (2021) Kacey J. Prentice et al. NATURE
- The elegant complexity of mammalian ecto-5′-nucleotidase (CD73)
- (2021) Karel P. Alcedo et al. TRENDS IN CELL BIOLOGY
- CD73-positive extracellular vesicles promote glioblastoma immunosuppression by inhibiting T-cell clonal expansion
- (2021) Ming Wang et al. Cell Death & Disease
- CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
- (2021) Enja Schneider et al. Nature Communications
- Profound inhibition of CD73-dependent formation of anti-inflammatory adenosine in B cells of SLE patients
- (2021) Julia Hesse et al. EBioMedicine
- Recent advances with alkaline phosphatase isoenzymes and their inhibitors
- (2020) Dana M. Zaher et al. ARCHIV DER PHARMAZIE
- Adenosine signalling is prognostic for cancer outcome and has predictive utility for immunotherapeutic response
- (2020) Ben Sidders et al. CLINICAL CANCER RESEARCH
- The single-cell pathology landscape of breast cancer
- (2020) Hartland W. Jackson et al. NATURE
- Ticagrelor and preconditioning in patients with stable coronary artery disease (TAPER-S): a randomized pilot clinical trial
- (2020) D. D’Amario et al. Trials
- CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
- (2020) Miao Yu et al. Nature Communications
- Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia
- (2020) Karolina Losenkova et al. JOURNAL OF CELL SCIENCE
- Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
- (2020) Rui Yang et al. Journal for ImmunoTherapy of Cancer
- Adenylate Kinase and Metabolic Signaling in Cancer Cells
- (2020) Aleksandr Klepinin et al. Frontiers in Oncology
- Identification of Adenosine Deaminase Inhibitors by Metal‐binding Pharmacophore Screening
- (2020) Rebecca N Adamek et al. ChemMedChem
- Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer
- (2020) Sunny Z Wu et al. EMBO JOURNAL
- Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ecto-Nucleotidases CD73 and CD39
- (2020) Jenna L. Jeffrey et al. JOURNAL OF MEDICINAL CHEMISTRY
- The adenosine pathway in immuno-oncology
- (2020) Bertrand Allard et al. Nature Reviews Clinical Oncology
- Biological functions of lymphatic vessels
- (2020) Tatiana V. Petrova et al. SCIENCE
- Proteome activity landscapes of tumor cell lines determine drug responses
- (2020) Martin Frejno et al. Nature Communications
- Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia
- (2020) Nesrine Aroua et al. Cancer Discovery
- Metabolic Modulation of Immunity: A New Concept in Cancer Immunotherapy
- (2020) Luana Guerra et al. Cell Reports
- Structural and Functional Characterization of Engineered Bifunctional Fusion Proteins of CD39 and CD73 Ectonucleotidases.
- (2020) Elizabeth H. Zhong et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Pharmacological and genetic strategies for targeting adenosine to enhance adoptive T cell therapy of cancer
- (2020) Kevin Sek et al. CURRENT OPINION IN PHARMACOLOGY
- CD73 contributes to anti‐inflammatory properties of afferent lymphatic endothelial cells in humans and mice
- (2020) Dominik Eichin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases
- (2020) Derek Strassheim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy
- (2020) Stephen M. Hatfield et al. JOURNAL OF CLINICAL INVESTIGATION
- Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production
- (2020) Xiaohui Du et al. JOURNAL OF MEDICINAL CHEMISTRY
- Single-cell metabolic profiling of human cytotoxic T cells
- (2020) Felix J. Hartmann et al. NATURE BIOTECHNOLOGY
- Fluorescent Probes for Ecto-5′-nucleotidase (CD73)
- (2020) Constanze C. Schmies et al. ACS Medicinal Chemistry Letters
- Adenosine metabolism in the vascular system
- (2020) Gennady G. Yegutkin BIOCHEMICAL PHARMACOLOGY
- NAD+ metabolism and its roles in cellular processes during ageing
- (2020) Anthony J. Covarrubias et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Metastasis and immune evasion from extracellular cGAMP hydrolysis
- (2020) Jun Li et al. Cancer Discovery
- Intratumoral generation of 2-fluoroadenine to treat solid malignancies of the head and neck
- (2019) Turang E. Behbahani et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage
- (2019) Julian Zeiner et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
- (2019) Jérôme Galon et al. NATURE REVIEWS DRUG DISCOVERY
- The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment
- (2019) Elena De Marchi et al. ONCOGENE
- CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
- (2019) Siqi Chen et al. Nature Communications
- Microvesicles expressing adenosinergic ectoenzymes and their potential role in modulating bone marrow infiltration by neuroblastoma cells
- (2019) Fabio Morandi et al. OncoImmunology
- Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP
- (2019) Todd A. Johnson et al. Frontiers in Pharmacology
- Structure–Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5′-Nucleotidase (CD73) Inhibitors
- (2019) Anna Junker et al. JOURNAL OF MEDICINAL CHEMISTRY
- Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses
- (2019) Fanghui Zhang et al. IMMUNITY
- CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans
- (2019) Pouya Joolharzadeh et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cancer Treatment in the Genomic Era
- (2019) Gary J. Doherty et al. Annual Review of Biochemistry
- Purine Release, Metabolism, and Signaling in the Inflammatory Response
- (2019) Joel Linden et al. Annual Review of Immunology
- Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39
- (2019) Maisa C. Takenaka et al. NATURE NEUROSCIENCE
- High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging
- (2019) Weizhe Li et al. Nature Protocols
- Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies
- (2019) Ivan Perrot et al. Cell Reports
- Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis
- (2019) Bertrand Allard et al. OncoImmunology
- Exosomes
- (2019) D. Michiel Pegtel et al. Annual Review of Biochemistry
- An Exceptionally Potent Inhibitor of Human CD73
- (2019) Christine E. Bowman et al. BIOCHEMISTRY
- Metastasis Suppressors NME1 and NME2 Promote Dynamin 2 Oligomerization and Regulate Tumor Cell Endocytosis, Motility and Metastasis.
- (2019) Imran Khan et al. CANCER RESEARCH
- Red blood cell dysfunction: a new player in cardiovascular disease
- (2019) John Pernow et al. CARDIOVASCULAR RESEARCH
- Xenograft and organoid model systems in cancer research
- (2019) Margit Bleijs et al. EMBO JOURNAL
- The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases
- (2019) Luca Antonioli et al. PHARMACOLOGICAL REVIEWS
- Platelets, Thrombo-Inflammation, and Cancer: Collaborating With the Enemy
- (2019) Ana Luisa Palacios-Acedo et al. Frontiers in Immunology
- Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
- (2019) Selena Vigano et al. Frontiers in Immunology
- Hallmarks of Endothelial Cell Metabolism in Health and Disease
- (2019) Xuri Li et al. Cell Metabolism
- Tumor angiogenesis: causes, consequences, challenges and opportunities
- (2019) Roberta Lugano et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Inorganic Polyphosphates As Storage for and Generator of Metabolic Energy in the Extracellular Matrix
- (2019) Werner E.G. Müller et al. CHEMICAL REVIEWS
- Harnessing innate immunity in cancer therapy
- (2019) Olivier Demaria et al. NATURE
- Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity
- (2019) Xian-Yang Li et al. Cancer Discovery
- Adenosine Metabolism: Emerging Concepts for Cancer Therapy
- (2019) Detlev Boison et al. CANCER CELL
- Phase II Trial of a DNA Vaccine Encoding Prostatic Acid Phosphatase (pTVG-HP [MVI-816]) in Patients With Progressive, Nonmetastatic, Castration-Sensitive Prostate Cancer
- (2019) Douglas G. McNeel et al. JOURNAL OF CLINICAL ONCOLOGY
- Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma
- (2019) Sangeeta Goswami et al. NATURE MEDICINE
- The Platelet Lifeline to Cancer: Challenges and Opportunities
- (2018) Monika Haemmerle et al. CANCER CELL
- Phase 1 Trials of anti-ENPP3 antibody drug conjugates in advanced refractory renal cell carcinomas
- (2018) John A Thompson et al. CLINICAL CANCER RESEARCH
- Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile
- (2018) Pervaiz Ali Channar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- The fibrotic tumor stroma
- (2018) Mitsuo Yamauchi et al. JOURNAL OF CLINICAL INVESTIGATION
- The NDPK/NME superfamily: state of the art
- (2018) Mathieu Boissan et al. LABORATORY INVESTIGATION
- Current and future antiplatelet therapies: emphasis on preserving haemostasis
- (2018) James D. McFadyen et al. Nature Reviews Cardiology
- Pharmacology of Adenosine Receptors: The State of the Art
- (2018) Pier Andrea Borea et al. PHYSIOLOGICAL REVIEWS
- Staphylococcus aureustargets the purine salvage pathway to kill phagocytes
- (2018) Volker Winstel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging
- (2018) Eduardo N. Chini et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Forodesine in the treatment of relapsed/refractory peripheral T-cell lymphoma: an evidence-based review
- (2018) Shinichi Makita et al. OncoTargets and Therapy
- CD38-mediated immunosuppression as a mechanism of tumor cell escape from PD-1/PD-L1 blockade
- (2018) Limo Chen et al. Cancer Discovery
- Quantitative Analysis of Immune Infiltrates in Primary Melanoma
- (2018) Robyn D. Gartrell et al. Cancer Immunology Research
- Who Is Who in Adenosine Transport
- (2018) Marçal Pastor-Anglada et al. Frontiers in Pharmacology
- Targeting adenosine for cancer immunotherapy
- (2018) Robert D. Leone et al. Journal for ImmunoTherapy of Cancer
- Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes
- (2018) Adnan Ashraf et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- Small molecule activator of Nm23/NDPK as an inhibitor of metastasis
- (2018) Jae-Jin Lee et al. Scientific Reports
- Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
- (2018) Moshe Sade-Feldman et al. CELL
- Human adenosine deaminase 2 deficiency: A multi-faceted inborn error of immunity
- (2018) Leen Moens et al. IMMUNOLOGICAL REVIEWS
- Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors
- (2018) Mercedes Garcia-Gil et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets
- (2017) Bertrand Allard et al. IMMUNOLOGICAL REVIEWS
- Extracellular NME proteins: a player or a bystander?
- (2017) Patrizia Romani et al. LABORATORY INVESTIGATION
- Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma
- (2017) David Kung-Chun Chiu et al. Nature Communications
- Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
- (2017) Yiming Xu et al. Nature Communications
- ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions
- (2017) Heidrun Degen et al. Journal of the American Heart Association
- CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer
- (2017) Jieyao Li et al. OncoImmunology
- Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer
- (2016) S R Rao et al. BRITISH JOURNAL OF CANCER
- A Landscape of Pharmacogenomic Interactions in Cancer
- (2016) Francesco Iorio et al. CELL
- Human adenosine deaminases ADA1 and ADA2 bind to different subsets of immune cells
- (2016) Yuliia Kaljas et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase
- (2016) Kiran S. Toti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cancer metabolism: a therapeutic perspective
- (2016) Ubaldo E. Martinez-Outschoorn et al. Nature Reviews Clinical Oncology
- Medicinal chemistry of adenosine, P2Y and P2X receptors
- (2016) Kenneth A. Jacobson et al. NEUROPHARMACOLOGY
- Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance
- (2016) Nicholas Syn et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- CD73-adenosine reduces immune responses and survival in ovarian cancer patients
- (2016) Pierre-Olivier Gaudreau et al. OncoImmunology
- Targeting CD73 in the tumor microenvironment with MEDI9447
- (2016) Carl M. Hay et al. OncoImmunology
- One-carbon metabolism and epigenetics: understanding the specificity
- (2015) Samantha J. Mentch et al. Annals of the New York Academy of Sciences
- Polyoxometalates—Potent and selective ecto-nucleotidase inhibitors
- (2015) Sang-Yong Lee et al. BIOCHEMICAL PHARMACOLOGY
- AGS16F Is a Novel Antibody Drug Conjugate Directed against ENPP3 for the Treatment of Renal Cell Carcinoma
- (2015) F. Donate et al. CLINICAL CANCER RESEARCH
- Loss of CD73-mediated actin polymerization promotes endometrial tumor progression
- (2015) Jessica L. Bowser et al. JOURNAL OF CLINICAL INVESTIGATION
- DNA methylation pathways and their crosstalk with histone methylation
- (2015) Jiamu Du et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages
- (2015) E Six et al. Cell Death & Disease
- Functional Role of G9a Histone Methyltransferase in Cancer
- (2015) Francesco Casciello et al. Frontiers in Immunology
- Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate
- (2015) Lili Feng et al. NEOPLASIA
- A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007
- (2014) Kathy D. Miller et al. BREAST CANCER RESEARCH AND TREATMENT
- Gene Expression Markers of Efficacy and Resistance to Cetuximab Treatment in Metastatic Colorectal Cancer: Results from CALGB 80203 (Alliance)
- (2014) S. M. Cushman et al. CLINICAL CANCER RESEARCH
- Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities
- (2014) Gennady G. Yegutkin CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Ecto-5′-nucleotidase/CD73 enhances endothelial barrier function and sprouting in blood but not lymphatic vasculature
- (2014) Gennady G. Yegutkin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- CD73-Generated Adenosine Restricts Lymphocyte Migration into Draining Lymph Nodes
- (2014) Masahide Takedachi et al. JOURNAL OF IMMUNOLOGY
- Role of TGF-β Signaling in Generation of CD39+CD73+Myeloid Cells in Tumors
- (2014) Sergey V. Ryzhov et al. JOURNAL OF IMMUNOLOGY
- Adenosine-Mediated Effects of Ticagrelor
- (2014) Marco Cattaneo et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Moonlighting Adenosine Deaminase: A Target Protein for Drug Development
- (2014) Antoni Cortés et al. MEDICINAL RESEARCH REVIEWS
- Adenosine Inhibits Tumor Cell Invasion via Receptor-Independent Mechanisms
- (2014) S. S. Virtanen et al. MOLECULAR CANCER RESEARCH
- Metabolism of stromal and immune cells in health and disease
- (2014) Bart Ghesquière et al. NATURE
- Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives
- (2014) Yuanjun Li et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- MethHC: a database of DNA methylation and gene expression in human cancer
- (2014) Wei-Yun Huang et al. NUCLEIC ACIDS RESEARCH
- Effects of Adenosine on Lymphangiogenesis
- (2014) Bénédicte Lenoir et al. PLoS One
- Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling
- (2014) M. Boissan et al. SCIENCE
- The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth
- (2014) Hyunjoo Kim et al. Nature Communications
- Targeting Cancer-Derived Adenosine:New Therapeutic Approaches
- (2014) A. Young et al. Cancer Discovery
- Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity
- (2014) J. Bastid et al. Cancer Immunology Research
- Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists
- (2014) M. V. Sitkovsky et al. Cancer Immunology Research
- Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?
- (2013) J. D. Hohmann et al. BLOOD
- Cancer as a metabolic disease: implications for novel therapeutics
- (2013) T. N. Seyfried et al. CARCINOGENESIS
- Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies
- (2013) Eyal Grunebaum et al. Current Opinion in Allergy and Clinical Immunology
- Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells
- (2013) Yuting Ma et al. IMMUNITY
- Anti-CD73 therapy impairs tumor angiogenesis
- (2013) Bertrand Allard et al. INTERNATIONAL JOURNAL OF CANCER
- Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis
- (2013) Rebecca L. Williams-Karnesky et al. JOURNAL OF CLINICAL INVESTIGATION
- Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
- (2013) Jérôme Galon et al. JOURNAL OF PATHOLOGY
- Therapeutic Potentials of Ecto-Nucleoside Triphosphate Diphosphohydrolase, Ecto-Nucleotide Pyrophosphatase/Phosphodiesterase, Ecto-5′-Nucleotidase, and Alkaline Phosphatase Inhibitors
- (2013) Mariya al-Rashida et al. MEDICINAL RESEARCH REVIEWS
- The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29
- (2013) James D. Young et al. MOLECULAR ASPECTS OF MEDICINE
- Adenosine receptors as drug targets — what are the challenges?
- (2013) Jiang-Fan Chen et al. NATURE REVIEWS DRUG DISCOVERY
- CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
- (2013) S. Loi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Conservation and divergence in the transcriptional programs of the human and mouse immune systems
- (2013) T. Shay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enzyme-coupled assays for simultaneous detection of nanomolar ATP, ADP, AMP, adenosine, inosine and pyrophosphate concentrations in extracellular fluids
- (2012) Mikko Helenius et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Insights into the biology and prevention of tumor metastasis provided by the Nm23 metastasis suppressor gene
- (2012) Natascia Marino et al. CANCER AND METASTASIS REVIEWS
- Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities
- (2012) Gennady G. Yegutkin et al. FASEB JOURNAL
- Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice
- (2012) Xiaofeng Sun et al. HEPATOLOGY
- Purinergic Signaling during Inflammation
- (2012) Holger K. Eltzschig et al. NEW ENGLAND JOURNAL OF MEDICINE
- ENTPD1/CD39 is a promising therapeutic target in oncology
- (2012) J Bastid et al. ONCOGENE
- Cellular function and molecular structure of ecto-nucleotidases
- (2012) Herbert Zimmermann et al. Purinergic Signalling
- Adenosine Kinase Deficiency Disrupts the Methionine Cycle and Causes Hypermethioninemia, Encephalopathy, and Abnormal Liver Function
- (2011) Magnus K. Bjursell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells
- (2011) Gennady G. Yegutkin et al. ANGIOGENESIS
- Different role of CD73 in leukocyte trafficking via blood and lymph vessels
- (2011) A. Algars et al. BLOOD
- A role for nucleotides in support of breast cancer angiogenesis: heterologous receptor signalling
- (2011) N Yokdang et al. BRITISH JOURNAL OF CANCER
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy
- (2011) Marjolein de Groot et al. EPILEPSIA
- Altered purinergic signaling in CD73-deficient mice inhibits tumor progression
- (2011) Gennady G. Yegutkin et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer
- (2011) Beat M. Künzli et al. Purinergic Signalling
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
- (2011) M. Michaud et al. SCIENCE
- CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice
- (2010) Xiaofeng Sun et al. GASTROENTEROLOGY
- Disordered Lymphoid Purine Metabolism Contributes to the Pathogenesis of Persistent Borrelia garinii Infection in Mice
- (2010) G. G. Yegutkin et al. JOURNAL OF IMMUNOLOGY
- Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer
- (2010) Philip W. Kantoff et al. NEW ENGLAND JOURNAL OF MEDICINE
- Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation
- (2010) R. Corriden et al. Science Signaling
- Purinergic mechanisms in breast cancer support intravasation, extravasation and angiogenesis
- (2009) Iain L.O. Buxton et al. CANCER LETTERS
- Adenosine signaling and function in glial cells
- (2009) D Boison et al. CELL DEATH AND DIFFERENTIATION
- Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
- (2009) Michael R. Elliott et al. NATURE
- Adenosine A2A receptor is a unique angiogenic target of HIF-2 in pulmonary endothelial cells
- (2009) A. Ahmad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade
- (2008) Gennady G. Yegutkin BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Adenosine kinase and ribokinase – the RK family of proteins
- (2008) J. Park et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
- (2008) Fabio Malavasi et al. PHYSIOLOGICAL REVIEWS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now