Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells

(2012) Hsing-Chen Tsai et al.   CANCER CELL

Rethinking the purinergic neuron-glia connection

(2012) B. B. Fredholm   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity

(2012) D. Lovatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epileptogenesis: Can the Science of Epigenetics Give Us Answers?

(2012) Farah D. Lubin   Epilepsy Currents

ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites

(2011) Michele Zampieri et al.   BIOCHEMICAL JOURNAL

The methylation hypothesis: Do epigenetic chromatin modifications play a role in epileptogenesis?

(2011) Katja Kobow et al.   EPILEPSIA

Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy

(2011) Eleonora Aronica et al.   EPILEPSIA

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice

(2011) Hai-Ying Shen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study

(2011) Jane de Tisi et al.   LANCET

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

The time course of acquired epilepsy: Implications for therapeutic intervention to suppress epileptogenesis

(2011) F. Edward Dudek et al.   NEUROSCIENCE LETTERS

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

(2010) Irfan A. Qureshi et al.   NEUROBIOLOGY OF DISEASE

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus

(2009) Xianying Amy Cui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adenosine signaling and function in glial cells

(2009) D Boison et al.   CELL DEATH AND DIFFERENTIATION

Adenosine augmentation therapies (AATs) for epilepsy: Prospect of cell and gene therapies

(2009) Detlev Boison   EPILEPSY RESEARCH

Antiepileptic effects of silk-polymer based adenosine release in kindled rats

(2009) Cory Szybala et al.   EXPERIMENTAL NEUROLOGY

Increased Reelin Promoter Methylation Is Associated With Granule Cell Dispersion in Human Temporal Lobe Epilepsy

(2009) Katja Kobow et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Epigenetic side-effects of common pharmaceuticals: A potential new field in medicine and pharmacology

(2009) Antonei B. Csoka et al.   MEDICAL HYPOTHESES

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Silk polymer-based adenosine release: Therapeutic potential for epilepsy

(2008) Andrew Wilz et al.   BIOMATERIALS

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice

(2008) Tianfu Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Activity-Dependent Suppression of Miniature Neurotransmission through the Regulation of DNA Methylation

(2008) E. D. Nelson et al.   JOURNAL OF NEUROSCIENCE

The adenosine kinase hypothesis of epileptogenesis

(2007) Detlev Boison   PROGRESS IN NEUROBIOLOGY