PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats
出版年份 2022 全文链接
标题
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats
作者
关键词
-
出版物
METABOLIC BRAIN DISEASE
Volume 37, Issue 6, Pages 1909-1929
出版商
Springer Science and Business Media LLC
发表日期
2022-06-10
DOI
10.1007/s11011-022-01026-0
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism
- (2022) Rishabh Khera et al. MOLECULES
- Neuroprotective Effect of Chrysophanol as a PI3K/AKT/mTOR Signaling Inhibitor in an Experimental Model of Autologous Blood-induced Intracerebral Hemorrhage
- (2022) Kuldeep Singh Jadaun et al. Current Medical Science
- Role of JAK-STAT and PPAR-Gamma Signalling Modulators in the Prevention of Autism and Neurological Dysfunctions
- (2022) Rishabh Khera et al. MOLECULAR NEUROBIOLOGY
- Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder
- (2022) Ria Gupta et al. Brain Sciences
- Neuroprotective Effect of α-Mangostin in Ameliorating Propionic Acid-Induced Experimental Model of Autism in Wistar Rats
- (2021) Aarti Tiwari et al. Brain Sciences
- Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism
- (2021) S Rahi et al. HUMAN & EXPERIMENTAL TOXICOLOGY
- The autistic-like behaviors development during weaning and sexual maturation in VPA-induced autistic-like rats is accompanied by gut microbiota dysbiosis
- (2021) Qingmin Kong et al. PeerJ
- Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS
- (2021) Elizabeth Minj et al. NEUROCHEMICAL RESEARCH
- Targeting PI3K-AKT/mTOR signaling in the prevention of autism
- (2021) Aarti Sharma et al. NEUROCHEMISTRY INTERNATIONAL
- Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration
- (2021) Sajad Fakhri et al. PHYTOMEDICINE
- Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism
- (2020) Giorgi Lobzhanidze et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus
- (2020) Jing-Ying Lin et al. Aging-US
- The pharmacological properties of chrysophanol, the recent advances
- (2020) Siyu Su et al. BIOMEDICINE & PHARMACOTHERAPY
- Assessment of oxidative stress in autism spectrum disorder using reactive oxygen metabolites and biological antioxidant potential
- (2020) Masahito Morimoto et al. PLoS One
- Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
- (2020) Zhi-Xiang Xu et al. Nature Communications
- Reactive Glia Inflammatory Signaling Pathways and Epilepsy
- (2020) Pascual Sanz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Exploring the spatial working memory and visual perception in children with autism spectrum disorder and general population with high autism-like traits
- (2020) Manxue Zhang et al. PLoS One
- Investigation of low dose cabazitaxel potential as microtubule stabilizer in experimental model of Alzheimer's disease: Restoring neuronal cytoskeleton
- (2020) Pallavi Duggal et al. Current Alzheimer Research
- Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
- (2020) Hiroaki Sacai et al. Nature Communications
- Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder
- (2020) Dionisio A. Amodeo et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
- (2019) Sachchida Nand Rai et al. NEUROTOXICITY RESEARCH
- Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD
- (2019) Jennifer R. Mepham et al. NEUROTOXICITY RESEARCH
- Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder
- (2019) Soaleha Shams et al. DEVELOPMENTAL PSYCHOBIOLOGY
- Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ175 mice
- (2019) Khaled S. Abd-Elrahman et al. Molecular Brain
- Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors
- (2019) Gabriella E. DiCarlo et al. JOURNAL OF CLINICAL INVESTIGATION
- Assessment of Apoptosis Pathway in Peripheral Blood of Autistic Patients
- (2019) Mohammad Mahdi Eftekharian et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress
- (2019) Roohi Mirza et al. CHEMICO-BIOLOGICAL INTERACTIONS
- A meta-analysis of pro-inflammatory cytokines in autism spectrum disorders: Effects of age, gender, and latitude
- (2019) Amene Saghazadeh et al. JOURNAL OF PSYCHIATRIC RESEARCH
- A perturbed gene network containing PI3K–AKT, RAS–ERK and WNT–β-catenin pathways in leukocytes is linked to ASD genetics and symptom severity
- (2019) Vahid H. Gazestani et al. NATURE NEUROSCIENCE
- Chrysophanol exhibits inhibitory activities against colorectal cancer by targeting decorin
- (2019) Min Deng et al. CELL BIOCHEMISTRY AND FUNCTION
- Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder
- (2019) P. M. Abruzzo et al. Journal of Translational Medicine
- Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF-κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model
- (2019) Xiaopeng Tong et al. Journal of Stroke & Cerebrovascular Diseases
- Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats
- (2019) Melissa M. Meeking et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders
- (2018) Dae-Wook Kang et al. ANAEROBE
- Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway
- (2018) H.P. Dong et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- Chrysophanol inhibits endoplasmic reticulum stress in cerebral ischemia and reperfusion mice
- (2018) Yongmei Zhao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Molecular mechanisms of anti-inflammatory effect of chrysophanol, an active component of AST2017-01 on atopic dermatitis in vitro models
- (2018) Hyun-Ja Jeong et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice
- (2018) Xu Chu et al. NEUROCHEMICAL RESEARCH
- Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model
- (2018) Samantha L. Hodges et al. NEUROREPORT
- Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model
- (2018) Jeonghyun Choi et al. PLoS One
- Identifying Associations among Co-occurring Medical Conditions in Children with Autism Spectrum Disorders
- (2018) Ann M Neumeyer et al. Academic Pediatrics
- Tanshinone modulates the expression of Bcl-2 and Bax in cardiomyocytes and has a protective effect in a rat model of myocardial ischemia-reperfusion
- (2018) Rui Guo et al. Hellenic Journal of Cardiology
- PI3k/AKT signaling pathway: Erythropoiesis and beyond
- (2018) Mahjoobeh Jafari et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Reduced microglial activity and enhanced glutamate transmission in the basolateral amygdala in early CNS autoimmunity
- (2018) Shaona Acharjee et al. JOURNAL OF NEUROSCIENCE
- Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion
- (2018) Yongmei Zhao et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy
- (2018) Claudia Brandt et al. NEUROPHARMACOLOGY
- Molecular Pathology and Pharmacological Treatment of Autism Spectrum Disorder-Like Phenotypes Using Rodent Models
- (2018) Hsiao-Ying Kuo et al. Frontiers in Cellular Neuroscience
- Target regulation of PI3K/Akt/mTOR pathway by cannabidiol in treatment of experimental multiple sclerosis
- (2017) Sabrina Giacoppo et al. FITOTERAPIA
- Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo
- (2017) Li Lu et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism
- (2017) Hongmei Wu et al. LIFE SCIENCES
- Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders
- (2017) Sidharth Mehan et al. Neural Regeneration Research
- Resveratrol suppresses neuroinflammation in the experimental paradigm of autism spectrum disorders
- (2017) Ranjana Bhandari et al. NEUROCHEMISTRY INTERNATIONAL
- Chrysophanol Suppressed Glutamate-Induced Hippocampal Neuronal Cell Death via Regulation of Dynamin-Related Protein 1-Dependent Mitochondrial Fission
- (2017) Unbin Chae et al. PHARMACOLOGY
- mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways
- (2017) Farr Niere et al. Frontiers in Cellular Neuroscience
- Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study
- (2017) Carlos A. Pardo et al. Molecular Autism
- Increased signaling by the autism-related Engrailed-2 protein enhances dendritic branching and spine density, alters synaptic structural matching, and exaggerates protein synthesis
- (2017) Asma Soltani et al. PLoS One
- P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice
- (2016) Kai Zhang et al. NEUROSCIENCE LETTERS
- Neuroprotective effects of Chrysophanol against inflammation in middle cerebral artery occlusion mice
- (2016) Yongmei Zhao et al. NEUROSCIENCE LETTERS
- Altered neurotransmitter metabolism in adolescents with high-functioning autism
- (2016) Gerhard S. Drenthen et al. PSYCHIATRY RESEARCH-NEUROIMAGING
- Abnormalities of Inter- and Intra-Hemispheric Functional Connectivity in Autism Spectrum Disorders: A Study Using the Autism Brain Imaging Data Exchange Database
- (2016) Jung Min Lee et al. Frontiers in Neuroscience
- Behavioral Phenotyping of Juvenile Long-Evans and Sprague-Dawley Rats: Implications for Preclinical Models of Autism Spectrum Disorders
- (2016) Katherine M. Ku et al. PLoS One
- Peripheral brain-derived neurotrophic factor in autism spectrum disorder: a systematic review and meta-analysis
- (2016) Zhen Zheng et al. Scientific Reports
- PI3K/AKT/mTOR Signaling-Mediated Neuropeptide VGF in the Hippocampus of Mice Is Involved in the Rapid Onset Antidepressant-Like Effects of GLYX-13
- (2015) Yang Lu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Catalytic autoantibodies against myelin basic protein (MBP) isolated from serum of autistic children impair in vitro models of synaptic plasticity in rat hippocampus
- (2015) Mario Gonzalez-Gronow et al. JOURNAL OF NEUROIMMUNOLOGY
- Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons
- (2015) Zhaohua Xiao et al. JOURNAL OF NEUROIMMUNOLOGY
- mTOR and Erk1/2 Signaling in the Cerebrospinal Fluid-Contacting Nucleus is Involved in Neuropathic Pain
- (2015) Guangling Li et al. NEUROCHEMICAL RESEARCH
- Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
- (2015) Panchanan Maiti et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Experimental evidence for the potential of lycopene in the management of scopolamine induced amnesia
- (2015) Rajni Bala et al. RSC Advances
- Characterizing autism spectrum disorders by key biochemical pathways
- (2015) Megha Subramanian et al. Frontiers in Neuroscience
- Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders
- (2014) Jianling Chen et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice
- (2014) Nan Zhang et al. MEDIATORS OF INFLAMMATION
- Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice
- (2014) Shu Wang et al. Neural Regeneration Research
- Ubiquinol Improves Symptoms in Children with Autism
- (2014) Anna Gvozdjáková et al. Oxidative Medicine and Cellular Longevity
- Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders
- (2014) Bistra B. Nankova et al. PLoS One
- Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases
- (2014) Hidetoshi Kassai et al. Cell Reports
- mTOR signaling and its roles in normal and abnormal brain development
- (2014) Nobuyuki Takei et al. Frontiers in Molecular Neuroscience
- Akt2 Deficiency is Associated with Anxiety and Depressive Behavior in Mice
- (2013) Christina Leibrock et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Transient and rapid activation of Akt/GSK-3β and mTORC1 signaling by D3 dopamine receptor stimulation in dorsal striatum and nucleus accumbens
- (2013) Marie-Josèphe Salles et al. JOURNAL OF NEUROCHEMISTRY
- Antidepressant-like effect of ascorbic acid is associated with the modulation of mammalian target of rapamycin pathway
- (2013) Morgana Moretti et al. JOURNAL OF PSYCHIATRIC RESEARCH
- mTOR complexes in neurodevelopmental and neuropsychiatric disorders
- (2013) Mauro Costa-Mattioli et al. NATURE NEUROSCIENCE
- mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling
- (2013) E.R. Workman et al. NEUROPHARMACOLOGY
- Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism
- (2013) Golan Karvat et al. NEUROPSYCHOPHARMACOLOGY
- Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay
- (2013) Ozlem Bozdagi et al. Molecular Autism
- 5-HT6receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
- (2012) Julie Meffre et al. EMBO Molecular Medicine
- Rheum australe D. Don: A review of its botany, ethnobotany, phytochemistry and pharmacology
- (2012) Maan Bahadur Rokaya et al. JOURNAL OF ETHNOPHARMACOLOGY
- Etiology of autistic features: the persisting neurotoxic effects of propionic acid
- (2012) Afaf K El-Ansary et al. Journal of Neuroinflammation
- The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders
- (2012) Raymond H Thomas et al. Journal of Neuroinflammation
- Chrysophanol–phospholipid complex
- (2012) Devendra Singh et al. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
- De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes
- (2012) Jean-Baptiste Rivière et al. NATURE GENETICS
- Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism
- (2012) Michael J. Kane et al. PLoS One
- Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages
- (2012) Maggie L. Chow et al. PLoS Genetics
- Microbiology of regressive autism
- (2011) Sydney M. Finegold et al. ANAEROBE
- Involvement of PI3K, GSK-3β and PPARγ in the antidepressant-like effect of folic acid in the forced swimming test in mice
- (2011) Josiane Budni et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Desulfovibrio species are potentially important in regressive autism
- (2011) Sydney M. Finegold MEDICAL HYPOTHESES
- Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders
- (2010) Raymond H. Thomas et al. JOURNAL OF NEUROCHEMISTRY
- Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells
- (2010) Chi-Cheng Lu et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway
- (2010) Myung Sun Lee et al. PHYTOTHERAPY RESEARCH
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
- (2009) Jeffrey J. Hutsler et al. BRAIN RESEARCH
- Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine — a PDE1 inhibitor
- (2009) Rahul Deshmukh et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
- (2009) Emma Puighermanal et al. NATURE NEUROSCIENCE
- Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
- (2009) E. Santini et al. Science Signaling
- mTOR signaling: At the crossroads of plasticity, memory and disease
- (2009) Charles A. Hoeffer et al. TRENDS IN NEUROSCIENCES
- Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation
- (2008) J. A. Ronesi et al. JOURNAL OF NEUROSCIENCE
- Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism
- (2008) Sandy R. Shultz et al. NEUROPHARMACOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search