期刊
NEURAL REGENERATION RESEARCH
卷 9, 期 9, 页码 924-930出版社
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.133141
关键词
nerve regeneration; traditional Chinese medicine; chrysophanol; lead poisoning; lead; malondialdehyde; superoxide dismutase; glutathione peroxidase; neurons; neonatal mice; antioxidant; learning and memory; Morris water maze; step-down test; hippocampal neurons; ultrastructure; Medical Scientific Research Project of Health Bureau of Hebei Province; neural regeneration
资金
- Science and Technology Commission Foundation of Zhangjiakou City [1021098D]
- Medical Scientific Research Project of Health Bureau of Hebei Province [20100144]
- Natural Science Foundation of Hebei Province [H2012405016]
- Innovative Talents Project of Hebei North University [CXRC1325]
- Major Projects of Hebei North University [ZD201310]
Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice. At the end of lactation, chrysophanol (0.1, 1.0, 10.0 mg/kg) was administered to the neonatal mice by intraperitoneal injection for 15 days. Chrysophanol significantly alleviated injury to hippocampal neurons and improved learning and memory abilities in the lead-poisoned neonatal mice. Chrysophanol also significantly decreased lead content in blood, brain, heart, spleen, liver and kidney in the lead-exposed neonatal mice. The levels of malondialdehyde in the brain, liver and kidney were significantly reduced, and superoxide dismutase and glutathione peroxidase activities were significantly increased after chrysophanol treatment. Collectively, these findings indicate that chrysophanol can significantly reduce damage to hippocampal neurons in lead-exposed neonatal mice.
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