Article
Multidisciplinary Sciences
Masud Rabbani, Munirul M. Haque, Dipranjan Das Dipal, Md Ishrak Islam Zarif, Anik Iqbal, Amy Schwichtenberg, Naveen Bansal, Tanjir Rashid Soron, Syed Ishtiaque Ahmed, Sheikh Iqbal Ahamed
Summary: This study aimed to evaluate the behavioral patterns of children with ASD during and after the COVID-19 lockdown, and found that support in the areas of problematic behavior could mitigate future risks.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Orit Stolar, Ariela Hazan, Roni Enten Vissoker, Ibrahim Abu Kishk, Dana Barchel, Mirit Lezinger, Adi Dagan, Nir Treves, David Meiri, Matitiahu Berkovitch, Elkana Kohn, Eli Heyman
Summary: This study aimed to assess the safety of CBD-rich oil treatment in children and adolescents with ASD. The results of analyzing data from 59 participants showed that CBD-rich cannabis oil had a good safety profile and did not cause significant side effects in the short term. However, further long-term monitoring with a larger number of participants is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Medicine, General & Internal
James T. Nugent, Christine Bakhoum, Lama Ghazi, Jason H. Greenberg
Summary: This study compares the frequency of hypertension screening at health maintenance visits between children with and without autism.
Article
Multidisciplinary Sciences
Jean-Christophe Quillet, Michael Siani-Rose, Robert McKee, Bonni Goldstein, Myiesha Taylor, Itzhak Kurek
Summary: This study used machine learning techniques to analyze the effects of cannabis on biomarkers in children with ASD. The findings identified biomarkers that can distinguish between ASD and Typically Developing groups, as well as biomarkers associated with specific cannabinoids. Additionally, the study revealed the synergistic effects of non-cannabinoid plant molecules in MC treatment.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Katherine Byrne, Shuting Zheng, Somer Bishop, Juliana Boucher, Sheila Ghods, So Hyun Kim, Catherine Lord
Summary: The study shows that children with ASD exhibit more severe worsening of behaviors during fever compared to TD children, though there may be rare cases of behavioral improvements among ASD children. Further research is needed to elucidate the nature of this phenomenon.
Article
Gastroenterology & Hepatology
Mingxing Lou, Aihua Cao, Cuiyuan Jin, Kai Mi, Xiyue Xiong, Zhaoyang Zeng, Xu Pan, Jinlong Qie, Shangfeng Qiu, Yaofang Niu, Hao Liang, Yanping Liu, Lin Chen, Zhi Liu, Qing Zhao, Xiyan Qiu, Yuanxiang Jin, Xiaoqi Sheng, Zhibin Hu, Gulei Jin, Jingshi Liu, Xingyin Liu, Yichao Wang
Summary: Recent studies have revealed the developmental characteristics of gut microbiota in individuals with autism spectrum disorder (ASD), showing a distinct and progressive deviation in microbiota development, as well as extensive microbial changes before the age of 3.
Article
Computer Science, Hardware & Architecture
Fangyu Shi, Wei Sun, Huiyu Duan, Xiaotian Liu, Menghan Hu, Wei Wang, Guangtao Zhai
Summary: This study established an ASD painting database, analyzed the unique characteristics of paintings by children with ASD, and trained a classifier using extracted features as a potential screening tool for autism spectrum disorder.
Review
Nutrition & Dietetics
Priscila Kelly da Silva Bezerra do Nascimento, David Franciole Oliveira Silva, Tassia Louise Sousa Augusto de Morais, Adriana Augusto de Rezende
Summary: This review aimed to summarize scientific evidence on the relationship between zinc status and Autism Spectrum Disorder (ASD) in children and adolescents. A total of 52 studies were included, with 19 studies showing lower zinc concentrations in the ASD group. However, overall, there was no significant difference in zinc concentrations between children and adolescents with ASD compared to controls. More prospective studies with greater methodological rigor are needed to further characterize this relationship.
Review
Computer Science, Cybernetics
Ana Paula de Carvalho, Camila S. S. Braz, Sibele M. M. dos Santos, Renato A. C. Ferreira, Raquel O. O. Prates
Summary: This systematic literature review explores the potential of serious games for the treatment of children with Autism Spectrum Disorder (ASD). The review categorizes games based on the skills they aim to develop, their activities, and customization options. The review finds that there are many serious games focused on developing social and socio-emotional skills for ASD children. The study also identifies different strategies and features adopted in the games. The review suggests that offering more customization options can enhance the applicability and utility of serious games for ASD children.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Article
Medicine, General & Internal
Anders Pretzmann Mikkelsen, Iben Katinka Greiber, Nikolai Madrid Scheller, Ojvind Lidegaard
Summary: A nationwide retrospective cohort study in Denmark found no significant association between maternal exposure to epidural analgesia during labor and autism spectrum disorder in offspring.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Education & Educational Research
Y. O. Mukhamedshina, R. A. Fayzullina, I. A. Nigmatullina, C. S. Rutland, V. V. Vasina
Summary: This study evaluated the knowledge and experience of medical students/residents, physicians, and caregivers in Russia regarding the medical management of children with ASD. The results showed limited ASD knowledge among medical providers in Russia and identified the main problems in medical management of individuals with ASD. Possible solutions for these problems were proposed.
BMC MEDICAL EDUCATION
(2022)
Article
Multidisciplinary Sciences
Orsolya Kiss, Katalin Olah, Lili Julia Feher, Jozsef Topal
Summary: The study found that children tend to categorize fellow humans based on transient features rather than permanent features, while they are more likely to categorize dogs based on permanent features.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Matthew J. Maenner, Sierra J. Graves, Georgina Peacock, Margaret A. Honein, Coleen A. Boyle, Patricia M. Dietz, Peggy Honein
Summary: The ADDM Network monitored ASD among 8-year-old children based on text descriptions from medical and educational evaluations between 2000 and 2016. A new case definition developed in 2018 showed similar prevalence to the previous definition, with improved sensitivity and positive predictive value.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Health Care Sciences & Services
Jennifer Ferina, Melanie Kruger, Uwe Kruger, Daniel Ryan, Conor Anderson, Jenny Foster, Theresa Hamlin, Juergen Hahn
Summary: This study explored the use of artificial intelligence models to predict behavior episodes in individuals with autism spectrum disorder (ASD). By analyzing data on co-occurring conditions and environmental factors, the models were able to accurately predict the likelihood of behavior episodes. Environmental and gastrointestinal factors were found to be significant predictors in the population studied.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Anna Brzoska, Beata Kazek, Karolina Koziol, Agnieszka Kapinos-Gorczyca, Malgorzata Ferlewicz, Agnieszka Babraj, Anna Makosz-Raczek, Wirginia Likus, Justyna Paprocka, Pawel Matusik, Ewa Emich-Widera
Summary: The study found that compared to healthy peers, children with autism spectrum disorder have more feeding problems in early infancy, including shortened breastfeeding time, delayed introduction of dairy products, needing more trials to introduce new foods, delayed introduction of solid and lumpy foods, longer duration of bottle feeding, delayed attempts to eat using own hands, and needing greater parental support to divert their attention from food during eating.
Editorial Material
Pediatrics
Ann M. Neumeyer, Robyn P. Thom, Christopher J. McDougle
JORNAL DE PEDIATRIA
(2021)
Article
Genetics & Heredity
Dmitrijs Rots, Eric Chater-Diehl, Alexander J. M. Dingemans, Sarah J. Goodman, Michelle T. Siu, Cheryl Cytrynbaum, Sanaa Choufani, Ny Hoang, Susan Walker, Zain Awamleh, Joshua Charkow, Stephen Meyn, Rolph Pfundt, Tuula Rinne, Thatjana Gardeitchik, Bert B. A. de Vries, A. Chantal Deden, Erika Leenders, Michael Kwint, Constance T. R. M. Stumpel, Servi J. C. Stevens, Jeroen R. Vermeulen, Jeske V. T. van Harssel, Danielle G. M. Bosch, Koen L. van Gassen, Ellen van Binsbergen, Christa M. de Geus, Hein Brackel, Maja Hempel, Davor Lessel, Jonas Denecke, Anne Slavotinek, Jonathan Strober, Amy Crunk, Leandra Folk, Ingrid M. Wentzensen, Hui Yang, Fanggeng Zou, Francisca Millan, Richard Person, Yili Xie, Shuxi Liu, Lilian B. Ousager, Martin Larsen, Laura Schultz-Rogers, Eva Morava, Eric W. Klee, Ian R. Berry, Jennifer Campbell, Kristin Lindstrom, Brianna Pruniski, Ann M. Neumeyer, Jessica A. Radley, Chanika Phornphutkul, Berkley Schmidt, William G. Wilson, Katrin Ounap, Karit Reinson, Sander Pajusalu, Arie van Haeringen, Claudia Ruivenkamp, Roos Cuperus, Fernando Santos-Simarro, Maria Palomares-Bralo, Marta Pacio-Miguez, Alyssa Ritter, Elizabeth Bhoj, Elin Tonne, Kristian Tveten, Gerarda Cappuccio, Nicola Brunetti-Pierri, Leah Rowe, Jason Bunn, Margarita Saenz, Konrad Platzer, Mareike Mertens, Oana Caluseriu, Malgorzata J. M. Nowaczyk, Ronald D. Cohn, Peter Kannu, Ebba Alkhunaizi, David Chitayat, Stephen W. Scherer, Han G. Brunner, Lisenka E. L. M. Vissers, Tjitske Kleefstra, David A. Koolen, Rosanna Weksberg
Summary: Truncating variants in exons 33 and 34 of the SRCAP gene cause Floating-Harbor syndrome, while individuals with truncating variants proximal to the FLHS locus exhibit distinct clinical features including developmental delay, behavioral issues, and facial dysmorphism. A machine-learning model based on DNA methylation signature of FLHS classified affected individuals negatively, suggesting a unique DNAm signature associated with the non-FLHS SRCAP-related NDD. This study demonstrates the relationship between variant location, DNAm profile, and clinical phenotype in SRCAP-related disorders.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Clinical Neurology
Jamie K. Capal, Marian E. Williams, Deborah A. Pearson, Robin Kissinger, Paul S. Horn, Donna Murray, Kristn Currans, Bridget Kent, Martina Bebin, Hope Northrup, Joyce Y. Wu, Mustafa Sahin, Darcy A. Krueger
Summary: The study found a 25% clinical diagnosis rate of ASD in children with TSC, with many non-ASD children also exhibiting autistic features. Social behavior quality, facial expressions, and abnormal repetitive interests and behaviors were the characteristics most likely to distinguish children with ASD from those without. Participants meeting ADOS-2 criteria but not diagnosed with ASD showed intermediate developmental and ADOS-2 scores.
ANNALS OF NEUROLOGY
(2021)
Article
Education, Scientific Disciplines
Alexandra H. Vinson, Dorothea Iannuzzi, Amanda Bennett, Eric M. Butter, Alicia B. Curran, Amy Hess, Susan L. Hyman, Amy Kelly, Donna S. Murray, Lisa Nowinski, Lonnie Zwaigenbaum, Kristin Sohl
Summary: The ECHO Autism: Center Engagement program cultivates a learning environment that emphasizes shared learning and acknowledges the expertise of both facilitators and participants, leading to improvement in autism care.
JOURNAL OF CONTINUING EDUCATION IN THE HEALTH PROFESSIONS
(2022)
Article
Psychology, Developmental
Yue Yu, Lisa Ruble, John McGrew, Donna Murray
Summary: Activation refers to patients' belief, knowledge, ability, and persistence to manage care. This study examined factors related to parent activation in ASD and found two factors in the PAM-DD scale. This suggests caution should be exercised when treating PAM-DD as a Guttman and unidimensional scale.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychology, Developmental
Lauren Harris, Daniel Gilmore, Christopher Hanks, Daniel Coury, Susan Moffatt-Bruce, Jennifer H. Garvin, Brittany N. Hand
Summary: Autistic adults face barriers to primary care, but virtual visits can minimize these barriers. Virtual visits can improve patient comfort, safety, and communication with providers, while reducing travel time, sensory stressors, and barriers to communication.
Article
Psychology, Developmental
Darrah N. Haffner, Lindsay R. Bartram, Daniel L. Coury, Courtney E. Rice, Katherine J. Steingass, Melissa Moore-Clingenpeel, Nathalie L. Maitre
Summary: The study found that ADEC performed well in identifying children at risk for ASD in high-risk NICU cohort, showing better performance compared to using CBCL alone.
INFANT BEHAVIOR & DEVELOPMENT
(2021)
Article
Health Care Sciences & Services
Jonathan T. Megerian, Sangeeta Dey, Raun D. Melmed, Daniel L. Coury, Marc Lerner, Christopher J. Nicholls, Kristin Sohl, Rambod Rouhbakhsh, Anandhi Narasimhan, Jonathan Romain, Sailaja Golla, Safiullah Shareef, Andrey Ostrovsky, Jennifer Shannon, Colleen Kraft, Stuart Liu-Mayo, Halim Abbas, Diana E. Gal-Szabo, Dennis P. Wall, Sharief Taraman
Summary: This study tested the accuracy of an artificial intelligence-based software in diagnosing ASD. The software combines multiple inputs and uses a machine learning algorithm to generate results. The study found that the software had a high degree of accuracy and could diagnose ASD in a timely manner.
NPJ DIGITAL MEDICINE
(2022)
Article
Pediatrics
Jin Peng, Janice Townsend, Paul Casamassimo, Daniel L. Coury, Charitha Gowda, Beau Meyer
Summary: This study compares dental utilization and expenditures between children with and without behavioral health diagnoses in an accountable care organization. The findings show that children with behavioral health diagnoses are less likely to have preventive visits and more likely to have dental visits under general anesthesia. This has significant implications for children's dental health and medical expenses.
ACADEMIC PEDIATRICS
(2023)
Article
Psychology, Developmental
Daniel Gilmore, Lauren Harris, Christopher Hanks, Daniel Coury, Susan Moffatt-Bruce, Jennifer H. Garvin, Brittany N. Hand
Summary: Virtual visits are real-time telehealth services that enable communication between patients and providers using audio and/or video technology. Factors affecting the usability of virtual visits include technology considerations, logistical considerations, and expectations for visits.
Article
Pharmacology & Pharmacy
Elizabeth A. Barnhardt, Anita R. Narayanan, Daniel L. Coury
Summary: This article summarizes recent research on Serdexmethylphenidate (SDX), a new treatment option for Attention Deficit/Hyperactivity Disorder (ADHD). It has unique prodrug design and a relatively extended duration of action, which makes it a potentially safe medication with similar side effects to other stimulant medications. Its prodrug design may serve as a deterrent to intentional parenteral abuse, and its ability to be opened and sprinkled in food makes it an option for individuals with ADHD who struggle to swallow pills.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Psychology, Developmental
Anjalee G. Galion, Justin V. Farmer, Heidi D. Connolly, Virginia Allhusen, Amanda L. Bennett, Daniel Coury, Janet M. Lam, Ann Neumeyer, Kristin Sohl, Manisha A. Witmans, Beth Malow
Summary: Children with autism spectrum disorder (ASD) often experience sleep problems, specifically night wakings. The Autism Treatment Network/Autism Intervention Research Network on Physical Health (ATN/AIR-P) Sleep Committee developed a pathway to address these concerns, however, night wakings remained unaddressed. Through literature review, we propose an updated practice pathway to identify and treat night wakings in children with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Medicine, Research & Experimental
Beth A. Malow, Anjalee Galion, Frances Lu, Nan Kennedy, Colleen E. Lawrence, Alison Tassone, Lindsay O'Neal, Travis M. Wilson, Robert A. Parker, Paul A. Harris, Ann M. Neumeyer
Summary: This study demonstrates the feasibility of using online research delivery platforms for pediatric healthcare research, specifically focusing on interventions for sleep disorders in children with autism spectrum disorder. The study showed improved trial efficiency and positive feedback from participants, even though the study measures did not show significant improvements with treatment.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Psychology, Developmental
Brittany N. Hand, Daniel L. Coury, Susan White, Amy R. Darragh, Susan Moffatt-Bruce, Lauren Harris, Anne Longo, Jennifer H. Garvin
Summary: The study compared the continuity of care among autistic adult patients at a specialized medical center to national samples of autistic adults with private insurance or Medicare. It found that patients at the specialized medical center had better continuity of care compared to Medicare beneficiaries and similar continuity of care compared to privately insured individuals. This suggests that medical homes, like the one studied, may be a promising solution to improve healthcare delivery for the growing population of autistic adults.
Article
Psychology, Developmental
Olivia J. Lindly, James Chan, Rachel M. Fenning, Justin G. Farmer, Ann M. Neumeyer, Paul Wang, Mark Swanson, Robert A. Parker, Karen A. Kuhlthau
Summary: The study found that many school-aged children with autism spectrum disorder do not receive recommended vision care, and there are significant disparities in vision care among these children, highlighting the need for further attention and intervention.